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43篇 您的检索式:作者名="Fischer PM"
    题名 作者 年代 出处 被引量
1缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 2014中华高血压杂志2014,22,4:13
2Subjective memory complaints and objective memory impairment in the Vienna-Transdanube aging community显示文摘Jungwirth S Fischer PM Weissgram S 2004JAGS2004,52,:1
3Increase in NADPH - diaphorase - positive and neuronal NO synthase immunoreactive neurons in the rat spinal trigeminal nucleus following infusion of a NO donor - evidence for a feed - forward process in NO production involved in trigeminal nociception 显示文摘SCHLECHTWEG PM RODER J FISCHER MJ 2009Cephalalgia2009,29,5:1
4Turning the key on p53 显示文摘Lane DP Fischer PM 2004Nature2004,427,6977:1
5Blood pressure management in acute stroke: does the Scandinavian Candesartan Acute StrokeTrial ( SCAST) resolve all of the unanswered questions?显示文摘Fischer U Rothwell PM 2011Stroke2011,42,10:1
6Adverse eflects of Gz in civilian aerobatic pilots显示文摘Williams RS Werchan PM Fischer 1998Aviat Space Environ Med1998,69,3:1
7Inhibitors of cyelin - dependent kinases as anti -cancer therapeutics 显示文摘Fischer PM Lane DP 2000Current medicinal chemistry2000,7,12:1
8Pipeline emboliza- tion device (PED) for neurovascular reconstruction : initial experience in the treatment of 101 intracranial aneurysms and dissections 显示文摘Fischer S Vajda Z Aguilar PM 2012Neuroradiology2012,54,4:1
9CDK inhibitors in clinical de- velopment for the treatment of cancer显示文摘Fischer PM Gianella-Borradori A 2003Expert Opin Investig Drugs2003,12,6:1
10Untangling Tau hyperphos- phorylation in drug design for neurodegenerative diseases显示文摘Mazanetz MP Fischer PM 2007Nat Rev Drug Discov2007,6,6:1
11Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells显示文摘 Giordano S Comoglio PM 2004J-Biol-Chem2004,279,28:1
12Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics显示文摘 Lane DP 2000Curr Med Chem2000,7,12:1
13Recent progress in the discovery and development of eyclin-dependent kinase inhibitors 显示文摘Fischer PM Gianella-Borradori A 2005Expert Opin Investig Drugs2005,14,4:1
14Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases显示文摘Mazanetz MP Fischer PM 2007Nat Rev Drug Discov2007,6,6:1
15Synthesis,characterization,and biocompatibility of polyethylenimine-graft-poly(ethylene glycol)block copolymers显示文摘PETERSEN H FECHNER PM FISCHER D 2002Macromolecules2002,35,18:1
16The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases显示文摘Fischer PM 2004Curr Med Chem2004,11,12:1
17Arteriovenous fistula of the filum terminale : diagnosis, treatment, and literature review显示文摘Fischer S Aguilar PM Bassiouni H 2013Clin Neuroradiol2013,23,4:1
18A recent progress in the discovery and development of cyelin-dependent kinase in- hibitors显示文摘FISCHER PM GIANELLA-BORRADORI A 2005Expert Opin lnvestig Drugs2005,14,4:1
19Cassette dosing pharmacokinetics of a library of 2,6,9-trisuhstituted purine cyc- lin-dependent kinase 2 inhibitors prepared by parallel synthesis 显示文摘Raynaud FI Fischer PM Nutley BP 2004Mol Cancer Ther2004,3,3:1
20Cellular delivery of impermea- ble effector molecules in the form of conjugates with peptides ca- pable of mediating membrane translocation 显示文摘Fischer PM Krausz E Lane DP 2001Bioconjug Chem2001,12,6:1
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