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| 1 | Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis显示文摘Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular lesions.Several preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc patients.However,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition process.Thus,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy ADSCs.In light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis. | Irene Rosa Eloisa Romano Bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 2 | Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques显示文摘Innovative label-free microspectroscopy,which can simultaneously collect Brillouin and Raman signals,is used to characterize the viscoelastic properties and chemical composition of living cells with sub-micrometric resolution.The unprecedented statistical accuracy of the data combined with the high-frequency resolution and the high contrast of the recently built experimental setup permits the study of single living cells immersed in their buffer solution by contactless measurements.The Brillouin signal is deconvoluted in the buffer and the cell components,thereby revealing the mechanical heterogeneity inside the cell.In particular,a 20%increase is observed in the elastic modulus passing from the plasmatic membrane to the nucleus as distinguished by comparison with the Raman spectroscopic marker.Brillouin line shape analysis is even more relevant for the comparison of cells under physiological and pathological conditions.Following oncogene expression,cells show an overall reduction in the elastic modulus(15%)and apparent viscosity(50%).In a proof-of-principle experiment,the ability of this spectroscopic technique to characterize subcellular compartments and distinguish cell status was successfully tested.The results strongly support the future application of this technique for fundamental issues in the biomedical field. | Sara Mattana Maurizio Mattarelli Lorena Urbanelli Krizia Sagini Carla Emiliani Mauro Dalla Serra Daniele Fioretto Silvia Caponi | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 3 | Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients显示文摘 | Mussap M Dalla VM Fioretto P | 2002 | Kindney Int2002，61，： | 1 |
| 4 | Comparative study of sweet potato (Ipomoea batatas) varieties to estimate their utilization in the food industry显示文摘 | Cereda M P Fioretto R B | 1982 | Portuguese Turrialba1982，32，4： | 1 |
| 5 | The need for early pre- dictors of diabetic nephropathy risk: is albumin excretion rate sufficient显示文摘 | Caramori ML Fioretto P Mauer M | 2000 | Diabetes2000，49，9： | 1 |
| 6 | Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients显示文摘 | Mussap M Dalla VM Fioretto P | 2002 | Kidney Int2002，61，4： | 1 |
| 7 | Renal interstitial expansion in insulin-dependent diabetes mellitus显示文摘 | Lane P H Steffes M W Fioretto P | 1993 | Kidney Int1993，43，： | 1 |
| 8 | High-frequeney oscillatory ventilation associated with inhaled nitric oxide compared to pres- sure-controlled assist/control ventilation and inhaled nitric oxide in -blinded,crossover study 显示文摘 | Fioretto JR Batista KA Carpi MF | 2011 | Pediatr Pulm- onol2011，46，8： | 1 |
| 9 | Renal pro- tection in diabetes: role of glycemic control 显示文摘 | FIORETTO P BRUSEGHIN M BERT() I | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 10 | Lignin and cellulose degradation and nitrogen dynamics during decomposition of three leaf litter species in a Mediterranean ecosystem 显示文摘 | Fioretto A Di Nardo C Papa S Fuggi A | 2005 | Soil Biol Biochem2005，37，6： | 1 |
| 11 | A microwave system for moisture monitoring in wet powders for industrial applications 显示文摘 | Bianchi G DionigJ M Fioretto D | 1999 | Microwave Symposium Digest1999，4，： | 1 |
| 12 | The need for early predictors of diabetic nephropathy risk:is albumin excretion rate sufficient?显示文摘 | Caramori ML Fioretto P Mauer M | 2000 | Diabetes2000，49，9： | 1 |
| 13 | Reversal of lesions of diabetic nephropathy after pancreas transplantation显示文摘 | Fioretto P Steffes MW Sutherland DE | | 0，，： | 1 |
| 14 | Procalcitonin in children with sepsis and septic shock显示文摘 | Fioretto JR Borin FC Bonatto RC | 2007 | J Pediatr2007，83，4： | 1 |
| 15 | Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients显示文摘 | Fioretto P Sutherland DE Najafian B | | 0，，： | 1 |
| 16 | Antihypertensive treatment and muhifactorial approach for renal protection in diabetes显示文摘 | Solini A | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 17 | Soil activities related to nitrogen cycle under three plant cover types in Mediterranean environment显示文摘 | Rutigliano FA Castaldi S D'Ascoli R Papa S Carfora A Marzaioli R Fioretto A | 2009 | Applied Soil Ecology2009，43，： | 1 |
| 18 | Enhancing the predictive value of urinary albumin for diabetic nephropathy显示文摘 | Caramori ML Fioretto P Mauer M | 2006 | J Am Soe Nephrol2006，17，2： | 1 |
| 19 | The tox- icity of sulfamethazine to Daphnia magna and its addi- tivity to other veterinary sulfonamides and trime- thoprim 显示文摘 | De Liguoro M Fioretto B Poltronieri C | 2009 | Chemosphere2009，75，11： | 1 |
| 20 | Low glomerular fil-tration rate in normoalbuminuric type 1 diabetic patients an indica-tor of more advanced glomerular lesions 显示文摘 | CARAMORI M L FIORETTO P MAUER M | 2003 | Diabetes2003，52，4： | 1 |
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