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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Investigation of an outbreak of mult-drug resistant Pseudomonas aeruginosa in an intensive care burns unit显示文摘 | ROBERT S A FINDLAY R LANG S D | 2001 | J Hosp Infect2001，48，3： | 1 |
| 3 | Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast in- vasion显示文摘 | Jones R L Findlay J K Farnworth P G | 2006 | Endocrinology2006，147，2： | 1 |
| 4 | Gram Stain Can Be Used to Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Intensive Care Unit 显示文摘 | Vaught A Findlay R Davis R | 2014 | Am Surg2014，80，12： | 1 |
| 5 | The measurement of internal losses in 4-level Iasers显示文摘 | FINDLAY D CLAY R | 1966 | Physics Letters1966，20，3： | 1 |
| 6 | Familial adrenocorticotropin-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia显示文摘 | Findlay J C Sheeler L R Engeland W C | 1993 | J Clin Endocrinol Metab1993，76，： | 1 |
| 7 | Biochemical markers for measurement of predation effects on the biomass,community structure,nutritional status,and metabolic activity of microbial biofilms显示文摘 | White D Findlay R | 1988 | Hydrobiologia1988，159，1： | 1 |
| 8 | Relationships a- mong photosynthetic rate, bean yield and other character sing field - grown cuhivars of soybean 显示文摘 | Buttery B R Buzzell R I Findlay W I | 1980 | Can J Plant Sci1980，61，： | 1 |
| 9 | The variable-rate mortgage and risk in the mortgage market: An option theory perspective: A note显示文摘 | Findlay M C Capozza D R | 1977 | Journal of Money1977，9，2： | 1 |
| 10 | Target recognition by calmodulin : Dissecting the kinetics and affinity of interaction using short peptide sequences 显示文摘 | P M Bayley W A Findlay S R Martin | 1996 | Protein Science1996，5，： | 1 |
| 11 | Relative Backwardness, Direct Foreign Investment and Transfer of Technology显示文摘 | Findlay R | 1978 | Quarterly Journal of Economics1978，92，： | 1 |
| 12 | Current concepts of pathophysioloay and management of cerebral vasospasm fol- lowing aneurismal subarachnoid hemorrgage显示文摘 | Findlay J M Macdonald R L Weir B K A | 1991 | Cerebrovase Brain Metab Res1991，3，： | 1 |
| 13 | Eutroph- ication oflakes cannot be controlled by reducing nitrogen input: Results of a 37 -year whole-ecosystem experiment 显示文摘 | SCHINDLER D W HECKY R E FINDLAY D L | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，11： | 1 |
| 14 | Eutrophication of lakes cannot be controlled by reducing nitrogen input:Results of a 37-year whole-ecosystem experiment显示文摘 | Schindler D W Hecky R E Findlay D L | | 0，，： | 1 |
| 15 | Relative Backwardness,Direct Foreign Investment and the Transfer of Technology:A Simple Dynamic Model显示文摘 | Findlay R | 1978 | Quarterly Journal of Economics1978，，92： | 1 |
| 16 | Aluminum activates an anion channel in the apical cells of wheat roots 显示文摘 | Ryan P R Skerrett M Findlay G P | 1997 | Proceedings of the National Academy of Sciences(USA)1997，94，： | 1 |
| 17 | Relative Backwardness, Direct Foreign Investment, and the Transfer of Technology: A Simple Dynamic Model显示文摘 | Findlay R | 1978 | Quarterly Journal of Economics1978，116，： | 1 |
| 18 | Eutrophication of lakes cannot be controlled by reducing nitrogen input:Results of a 37-year whole-ecosystem experiment显示文摘 | Schindler D W Hecky R E Findlay D L | | 0，，： | 1 |
| 19 | Relative Backwardness, Direct For- eign Investment and the Transfer of Technology : A Simple Dynamic Model 显示文摘 | Findlay R | 1978 | Quarterly Journal of Economics1978，92，1： | 1 |
| 20 | Addition of transver- sus abdominis plane block to patient controlled analgesia for laparoscopic high anterior resection improves analgesia, re- duces opioid requirement and expedites recovery of bowel function显示文摘 | Ris F Findlay JM Hompes R | 2014 | Ann R Coll Surg Engl2014，96，8： | 1 |
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