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| 1 | Angiotensin2 induces connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | FINCKENBERG P INKINEN K AHONEN J | 2003 | Am J Pathol2003，163，： | 1 |
| 2 | Lipoic acid supplementation prevents cyclosporine- induced hypertension and nephrotoxicity in spontaneously hypertensive rats 显示文摘 | Louhelainen M Merasto S Finckenberg P | 2006 | J Hypertens2006，24，5： | 1 |
| 3 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 4 | Angiotensin Ⅱ induces connective tissue growth factor expression via calcineurin-dependent pathways显示文摘 | Finckenberg P Inkinen K Ahonen J | 2003 | Am J Pathol2003，163，： | 1 |
| 5 | AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney显示文摘 | J Lempi?inen P Finckenberg J Levijoki E Mervaala | 2012 | British Journal of Pharmacology2012，，6： | 1 |
| 6 | Angiotensin Ⅱ induces connective tissue growth factor gene expression via calcineurin-dependent pathways显示文摘 | Finckenberg P Inkinen K Ahonen J | | 0，，01： | 1 |
| 7 | Longterm intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats显示文摘 | Sipola M Finckenberg P Santisteban J | 2001 | J Physiol Pharmacol2001，52，： | 1 |
| 8 | Angiotensin II induces connective tissue growth factor expression via calcineurin- dependent pathways显示文摘 | Finckenberg P Inkinen K Lhonen J | 2003 | Am J Pathol2003，163，： | 1 |
| 9 | a-lactorphin and β-lactorphin improve arterial function in sponta- neously hypertensive rats显示文摘 | Sipola M Finckenberg P Vapaatalo H | 2002 | Life Sci2002，71，： | 1 |
| 10 | Effects of the calcium sensitizer OR-1896,a metabolite of levosimendan,on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats显示文摘 | Louhelainen M Merasto S Finckenberg P | 2010 | Br J Pharmacol2010，160，1： | 1 |
| 11 | Dexmedetomi- dine preconditioning ameliorates kidney ischemia-reperfusion inju- ry 显示文摘 | Lempiainen J Finckenberg P Mervaala EE | 2014 | Pharmacol Res Perspect2014，2，3： | 1 |
| 12 | Cyclosprine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on hig sodium diet显示文摘 | FINCKENBERG P LASSILA M INKINEN K | 2001 | Transplantation2001，71，： | 1 |
| 13 | AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney 显示文摘 | Lempiainen J Finckenberg P Levijoki J Mervaala E | 2012 | Br J Pharmacol2012，166，： | 1 |
| 14 | Effects of the calcium sensitizer OR-1896,a metabolite of levosimendan,on post-infarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats显示文摘 | Louhelainen M Merasto S Finckenberg P | 2010 | Br J Pharmacol2010，160，1： | 1 |
| 15 | Caloric re- striction ameliorates kidney ischaemia/reperfusion injury through PGC-1 a-eNOS pathway and enhanced autophagy显示文摘 | Lempi~tinen J Finckenberg P Mervaala EE | 2013 | Acta Physi- ol(Oxf)2013，208，4： | 1 |
| 16 | Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-lal-eNOS pathway and enhanced autophagy 显示文摘 | LempiainenJ Finckenberg P Mervaala EE eta1 | 2013 | Acta Physiol (Oxf)2013，208，4： | 1 |
| 17 | Magnesium supplementation prevents angiotensin Ⅱ-induced myocardial damage and CTGF overexpression显示文摘 | Merasto S Louhelainen M | 2005 | J Hypertension2005，32，2： | 1 |
| 18 | Effect of long-term intake of milk products on blood pressure in hypertensiverats显示文摘 | Sipola M Finckenberg P Korpela R | 2002 | Joumal of Dairy Research2002，69，1： | 1 |
| 19 | Magnesium supplementation prevents angiotensin II -induced myocardial damage and CTGF overexpression显示文摘 | Finckenberg P Merasto S Louhelainen M | 2005 | Hypertension2005，32，： | 1 |
| 20 | Antihypertensive opioid-like milk peptide α-lactorphin: lack of effect on behavioural tests in mice显示文摘 | Ijas Hanna Collin Marika Finckenberg Piet | 2004 | International Dairy Journal2004，14，： | 1 |
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