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| 1 | Immunotherapy – new perspective in lung cancer显示文摘Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer death.It is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung cancer.However,such malignancy has been increasingly subdivided into histological and molecular subtypes to guide treatment.Therapies can be used in adjuvant and palliative settings.Regarding immunotherapy,it has been widely tested in both first or subsequent palliative lines.In this sense,drugs such as pembrolizumab,nivolumab,atezolizumab,ipilimumab,avelumab,and durvalumab have been assessed in large studies.Some of these trials have also studied these medicines in adjuvant and in maintenance therapy.In recent years,advances in immunotherapy have raised the hope that the unfavorable prognosis observed in several affected individuals can be changed.Immunotherapy has increased the overall survival in squamous NSCLC,non-squamous NSCLC,and small cell lung cancer.However,it has added to the oncology practice some side effects that are unusual in standard chemotherapy and require special clinical support.In order to show how immunotherapy is being applied in the treatment of lung carcinoma,we reviewed the main studies in adjuvant and palliative scenarios.What is the better scheme?What is the better combination?What is the better dose?When should we use immunotherapy?Does programmed cell death ligand 1 expression significantly interfere in immunotherapy efficiency?Some of these questions have already been answered,while others require more investigations. | Fillipe Dantas Pinheiro Adriano Fernandes Teixeira Breno Bittencourt de Brito Filipe Antonio Franca da Silva Maria Luísa Cordeiro Santos Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，5： | 3 |
| 2 | Process evaluation of an 865MWe lignite fired O2/CO2 power plant显示文摘 | Klaus A Fillip J | 2006 | Energy Conversion and Management2006，47，1819： | 1 |
| 3 | Esterification of oleic acid with ethanol by 12- tungstophosphoric acid supported on zirconia显示文摘 | Claudinei F Olivcira Luiz M Dezaneti Fillipe A C Garci- a | 2010 | Applied Catalysis A : General2010，372，2： | 1 |
| 4 | Prevalence of diagnosed atrial fibrilla- tions in adults national implications for management and stroke prevention the anticoagulation and risk factors in atrial fibrillation (ATRIA) study 显示文摘 | Go A S Hylck E M Fillips K A | 2001 | JAMA2001，，285： | 1 |
| 5 | A six-month, supervised, erotic dressiest exercise program improves self-efficacy people with hum immunodeficiency virus: Odorized cotrolled trill显示文摘 | Fillips S Oldmedow L B Billy M J | 2006 | Aust J Physiotherapy2006，52，3： | 1 |
| 6 | Esterification of oleic acid with ethanol by 12-tungstophosphoric acidsupported on zirconia显示文摘 | CLAUDINEI F 0 LUIZ M D FILLIPE A C | 2010 | Appl Catal:A2010，372，11： | 1 |
| 7 | Network formation of cationic vesicle andpositively charged poly electrolytes : effect of polymercharge density and hydrophobic modification 显示文摘 | Fillipe E A | 2004 | Lang-muir2004，20，： | 1 |
| 8 | On the kinetics of magnesia hydration in magnesium acetate solutions显示文摘 | Fillipou D Katiforis N Papassiopi N | | 0，，74： | 1 |
| 9 | Inhibition of influenza virus production in virus-infected mice by RNA interference显示文摘 | Ge Q Fillip L Bai A | 2004 | Proc Natl Acad Sci USA2004，101，23： | 1 |
| 10 | Quality Assrance in Higher Education:Theoretical Considerations and Empirical Evidence 显示文摘 | Mien Segers & Fillip Doehy | 1996 | Studies in Educational Evaluation1996，，2： | 1 |
| 11 | On the na- ture of tribological contact in automotive brakes显示文摘 | Mikael Eriksson Fillip Bergman Staffan Jacobson | 2002 | Wear2002，252，： | 1 |
| 12 | Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis显示文摘 | Chojkier M Lyche KD fillip M | 1988 | Hepatology1988，8，8： | 1 |
| 13 | Network formatidn of cationic vesicle and posi tively charged polyelectrolytes:Effect of polymer charge densi ty and hydrophobic modification 显示文摘 | FILLIPE E A | 2004 | Langmuir2004，20，： | 1 |
| 14 | Terrestrial in situ cosmogenic nuclides,theory and application显示文摘 | Gosse JP Fillips FM | 2001 | Quatemary Science Reviews2001，20，： | 1 |
| 15 | Prognosistic value of proliferating cell nuclear antigen in gastric carcinoma显示文摘 | Fillipe MI Hall PA | 1991 | J Clin Pathol1991，44，4： | 1 |
| 16 | Enhanced colon tumor induction in uncoupling protein - 2 deficient mice is associated with NF - kappaB activation and oxidative stress 显示文摘 | Derdak Z Fillip P Sabo E | 2006 | Carcinogenesis2006，27，5： | 1 |
| 17 | Resolution and error in measuring gland cover change Effects on estimating net carbon release from Mexican terrestrial ecosystems显示文摘 | Riley R H Fillips D L Schuit M J | 1997 | International Journal of Remote Sensing1997，18，1： | 1 |
| 18 | Prevalence of diagnosed atrial fibrillation in adults national implications for management and stroke prevention the anticoagulation and risk factors in atrial fibrillation(ATRIA)study显示文摘 | Go AS Hylck EM Fillips KA | 2001 | JAMA2001，，285： | 1 |
| 19 | Es- terification of acetic acid with alcoholsusing supported ni- obium pentoxide on silica-alumina catalysts 显示文摘 | Valdeilson S B Ivoneide C L B Fillipe A C G | 2008 | Catal Today2008，，： | 1 |
| 20 | Influence of fire on woody vegetation of savanna and forest formations in the Cerrado biome显示文摘Wildfires have environmental,economic,and social impacts,and can shape the landscape and benefit ecosystems such as the Cerrado.This study evaluated the diversity,similarity,and floristic and structural differences of woody savanna and forest formations of the Cerrado,when affected and not affected by fire.Twenty-eight 25-400m2 plots were randomly allocated and divided into Burnt Cerrado and Unburnt Cerrado,Burnt Forest,and Unburnt Forest,and divided into three levels of inclusion according to diameter class(smaller than 2 cm,2-5 cm and larger than5 cm).Species were identified,DBH and height measured,and phyto sociological parameters such as volume,diversity,and floristic similarity evaluated.Burnt Cerrado had lower diversity,density,and dominance at all inclusion levels compared to the Unburnt Cerrado,and showed similarities between treatments at the inclusion levels.Burnt Forest had smaller differences in diversity,density,and dominance than Unburnt Forest.Forest formation was similar at level 1 of inclusion and in the total area.However,it was dissimilar at lower levels.The lower density and diversity of species at the lowest levels of inclusion was associated with mortality from fire. | Aline das Gracas Costa Fillipe Tamiozzo Pereira Torres Gumercindo Souza Lima Fabiano Rodrigues de Melo Carlos Moreira Miquelino Eleto Torres Bruno Leao Said Schettini Vicente Paulo Santana Neto AndréLuiz Lopes de Faria | 2023 | Journal of Forestry Research2023，34，5： | 0 |
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