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| 1 | Unsatisfying antiviral therapeutic effect in patients with mother-tochild transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study显示文摘Background:Few data are available regarding the progression of liver disease and therapeutic efficacy in chronic hepatitis B(HBV)carriers infected by mother-to-child transmission(MTCT).This study aimed to investigate these two aspects by comparing the adult chronic HBV carriers in MTCT group with those in horizontal transmission group.Methods:The 683 adult chronic HBV patients qualified for liver biopsy including 191 with MTCT and 492 with horizontal transmission entered the multi-center prospective study from October 2013 to May 2016.Biopsy results from 217 patients at baseline and 78 weeks post antiviral therapy were collected.Results:Patients infected by MTCT were more likely to have e antigen positive(68.6%vs.58.2%,x^2=-2.491,P=0.012)than those with horizontal transmission.However,in patients with MTCT,levels of alkaline phosphatase(ALP)(P=0.031),Fibroscan(P=0.013),N-terminal propeptide of Type III procollagen(PIIINP)(P=0.014),and Laminin(LN)(P=0.006)were high,in contrast to the patients with horizontal transmission for whom the levels of albumin(ALB)(P=0.041),matrix metalloproteinase-3(MMP-3)(P=0.001)were high.The 47.2% of patients with MTCT and 36.8%of those with horizontal transmission had significant liver fibrosis(P=0.013).Following antiviral therapy for 78 weeks,21.2%and 38.0%patients with MTCT and horizontal transmission acquired hepatitis B e antigen(HBeAg)clearance,respectively(P=0.043),and the virological response rates were 54.7%and 74.1%in the MTCT and horizontal groups,respectively(P=0.005).MTCT was a risk factor for HBeAg clearance and virological response.Conclusion:Adult patients with MTCT were more prone to severe liver diseases,and the therapeutic efficacy was relatively poor,which underlined the importance of earlier,long-term treatment and interrupting perinatal transmission. | Jun Li Xiao-Qin Dong Zhao Wu An-Lin Ma Shi-Bin Xie Xu-Qing Zhang Zhan-Qing Zhang Da-Zhi Zhang Wei-Feng Zhao Guo Zhang Jun Cheng Qing Xie Jun Li Zhi-Qiang Zou Ying-Xia Liu Gui-Qiang Wang Hong Zhao China Hepatitis B Related Fibrosis Assessment Research Group | 2019 | Chinese Medical Journal2019，，22： | 2 |
| 2 | Co-nsensus on evaluation d the diagnosis and efficacy of hepatic fibrosis显示文摘 | | 2002 | Zhonghua Ganzangbing Zazhi2002，10，： | 1 |
| 3 | Prednisone, azathioprine, and N - acetylcysteine forpul- monary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Raghu G Anstrom KJ | 2012 | N Engl J Med2012，366，21： | 1 |
| 4 | Consensus on evaluation of the diagnosis and efficacy of hepatic fibrosis显示文摘 | Hepatic fibrosis study group of chinese liver diseases association | 2002 | Zhonghua Gan Zang Bing Za Zhi2002，10，5： | 1 |
| 5 | An Official ATS/ERS/JRS/ALAT Statement : Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management 显示文摘 | ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 6 | Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Raghu G Anstrom K J | 2012 | N Engl J Med2012，366，21： | 1 |
| 7 | Prednisone,azathioprine,and N-Acetylcysteine for pulmonary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Raghu G Anstrom K J | | 0，，： | 1 |
| 8 | Consensus on evaluation of the diagnosis and efficacy of hepatic fibrosis显示文摘 | Hepatic Fibrosis Study Group of Chinese Liver Diseases Association | 2002 | Chin J Hepatology2002，10，5： | 1 |
| 9 | Amorphologic and molecular comparison 显示文摘 | Sun MA Wang BE Annoni A etal Two rat models of hepatic fibrosis | 1990 | Lab Invest1990，163，4： | 1 |
| 10 | A controlled trial of sildenafil in advanced idiopathic pulmonary fi- brosis显示文摘 | The Idiopathic Pulmonary Fibrosis Clinical Research Network | 2010 | N Engl J Med2010，363，： | 1 |
| 11 | Diagnosis and Treatment,International Consensus Statement显示文摘 | Idiopathic Pulmonary Fibrosis | 2000 | Am J Respir Crit Care Med2000，161，： | 1 |
| 12 | Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Martinez FJ de Andrade JA | 2014 | N Engl J Med2014，370，22： | 1 |
| 13 | Risk factors for intrauterine are associated with uhrasonographically detected severe early congenital muscular torticollis显示文摘 | Lee Y T constraint fibrosis in 2011 46 Cho S K Yoon K | 2011 | J Pediatr Surg2011，，3： | 1 |
| 14 | Pathogenetic role of a fibrogenic cytokine显示文摘 | BERNASCONI P TORCHIANA E CONFALOHIERI P Expression of transforming growth factor beta1 in dystrophic patient muscles correlates with fibrosis | 1995 | J Clin Invest1995，96，2： | 1 |
| 15 | Consensus on evaluation of the diagnosis and efficacy of hepatic fibrosis显示文摘 | Hepatic Fibrosis Study Group of Chinese Liver Disease Association | 2002 | Chin J Hepatology2002，10，5： | 1 |
| 16 | Mechanisms and treatement strategies显示文摘 | Friedman S L The cellular basis of hepatic fibrosis | 1993 | N Engl J Med1993，328，： | 1 |
| 17 | Prednisone, azathioprine, and N- acetylcysteine for pulmonary fibrosis 显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Raghu G Anstrom K J | 2012 | N Engl J Med2012，366，21： | 1 |
| 18 | Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network Martinez FJ de Andrade JA | 2014 | N Engl J Med2014，370，22： | 1 |
| 19 | A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis显示文摘 | Idiopathic Pulmonary Fibrosis Clinical Research Network | 2010 | N Engl J Med2010，363，7： | 1 |
| 20 | Cystic Fibrosis Foundation evidence-based guidelines for manage- ment of infants with cystic fibrosis 显示文摘 | Cystic Fibrosis Foundation Borowitz D Robinson KA | 2009 | J Pediatr2009，155，6： | 1 |
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