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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Seasonal study of dissolved CH4 , CO2 and N2O in a shallow tidal system of the bay of Cadiz (SW Spain) 显示文摘 | Ferron S Ortega T Gomez-Parra A | 2007 | Journal of Marine System2007，66，14： | 1 |
| 3 | Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation显示文摘 | Seliger B Ritz U Ferrone S | 2006 | Int J Cancer2006，118，1： | 1 |
| 4 | Perioperative C19 -9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma 显示文摘 | Ferrone C R Finkelstein D M Thayer S P | 2006 | J Clin Oncol2006，24，18： | 1 |
| 5 | Lost in translation:Obstacles to translational medicine显示文摘 | MANKOFF SP BRANDER C FERRONE S | 2004 | Journal of Traditional Medicines2004，2，1： | 1 |
| 6 | HLA-G and MIC expression in tumors and their role in anti-tumor immunity显示文摘 | Seliger B Abken H Ferrone S | 2003 | Trends Immunol2003，24，2： | 1 |
| 7 | Tumor microenvironment and immune escape显示文摘 | Ferrone S Whiteside TL | 2007 | Surg Oncol Clin N Am2007，16，4： | 1 |
| 8 | The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum显示文摘 | Fang S Ferrone M Yang C | 2001 | Proc Natl Acad Sci U S A2001，98，14： | 1 |
| 9 | Anterior Zielke instrumentation for spinal deformity inadults 显示文摘 | Kostuik JP Carl A Ferron S | 1989 | J Bone Joint Surg(Am)1989，71，6： | 1 |
| 10 | Functional and clinical relevance of chondroitin sulfate proteoglycan 4显示文摘 | CAMPOLI M FERRONE S WANG X | 2010 | Adv Cancer Res2010，109，： | 1 |
| 11 | Lost in Translation : Obstacles to Transla-tional Medicine显示文摘 | Mankoff SP Brander C Ferrone S | 2004 | J Transl Med2004，2，1： | 1 |
| 12 | Human Leukocyte antigen(HLA)class I defects in head and neck cancer:molecular mechanisms and clinical significance显示文摘 | Hunt JL Ferrone s | 2005 | Immunol Res2005，33，2： | 1 |
| 13 | Immune selective pressure and HLA class I antigen defects in malignant lesions显示文摘 | Chang C C Ferrone S | 2007 | Cancer Immunol Immunother2007，56，2： | 1 |
| 14 | TAP off-tumors on显示文摘 | Seliger B Maeurer MJ Ferrone S | 1997 | Immunol Today1997，18，6： | 1 |
| 15 | Soluble human leukocyte antigen-G serum level is elevated in melanoma patients and is further increased by interferon-alpha im- munotherapy显示文摘 | Ugurel S Rebmann V Ferrone S | 2001 | Cancer2001，92，2： | 1 |
| 16 | Safety, Feasibility, and Short-Term Outcomes of Single Port Access Colorectal Surgery: A Single Institutional Case-Matched Study显示文摘 | Sébastien Gaujoux Léon Maggiori Frédéric Bretagnol Marianne Ferron Yves Panis | 2012 | Journal of Gastrointestinal Surgery2012，，3： | 1 |
| 17 | A single-nucleotide deletion leads to rapid degradation of TAP-1 mRNA in a melanoma cell line显示文摘 | YANG T MCNALLY BA FERRONE S | 2003 | J Biol Chem2003，278，15： | 1 |
| 18 | HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story显示文摘 | Hicklin DJ Marineola FM Ferrone S | 1999 | Mol Med Today1999，5，4： | 1 |
| 19 | HLA class Ⅰ antigen downregulation in human cancer:T-cell immunotherapy revives an old story显示文摘 | Hicklin DJ Marincola FM Ferrone S | 1999 | Mol Med Today1999，5，： | 1 |
| 20 | HLA Class I antigen downregu- lation in human cancers : T-cell immunotherapy revives an old story 显示文摘 | Hicklin DJ Marineola FM Ferrone S | 1999 | Mol Med Today1999，5，4： | 1 |
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