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| 1 | Locally advanced rectal cancer:The importance of a multidisciplinary approach显示文摘Rectal cancer accounts for a relevant part of colorectal cancer cases,with a mortality of 4-10/100000 per year.The development of locoregional recurrences and the occurrence of distant metastases both influences the prognosis of these patients.In the last two decades,new multimodality strategies have improved the prognosis of locally advanced rectal cancer with a significant reduction of local relapse and an increase in terms of overall survival.Radical surgery still remains the principal curative treatment and the introduction of total mesorectal excision has significantly achieved a reduction in terms of local recurrence rates.The employment of neoadjuvant treatment,delivered before surgery,also achieved an improved local control and an increasedsphincter preservation rate in low-lying tumors,with an acceptable acute and late toxicity.This review describes the multidisciplinary management of rectal cancer,focusing on the effectiveness of neoadjuvant chemoradiotherapy and of post-operative adjuvant chemotherapy both in the standard combined modality treatment programs and in the ongoing research to improve these regimens. | Rossana Berardi Elena Maccaroni Azzurra Onofri Francesca Morgese Mariangela Torniai Michela Tiberi Consuelo Ferrini Stefano Cascinu | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils显示文摘 | McDonald PP Russo MP Ferrini S | 1998 | Blood1998，92，12： | 2 |
| 4 | Natural capital accounting perspectives:a pragmatic way forward显示文摘Introduction:Recent debates surrounding the application of natural capital accounting(NCA)have produced several approaches to further develop this system,as well as highlighted a number of conceptual and methodological issues that need to be resolved before mainstreaming NCA into policy and decision making.We argue that prolonged debate over the value concepts(i.e.,exchange versus other values)underpinning different modifications to NCA has slowed progress in experimentation and uptake by policymakers.Outcomes:Consequently we propose three broad approaches which can be progressed in parallel to reinvigorate experimentation with the NCA principles and practice,while at the same time generating policy relevant tools and evidence bases for decision support.The three approaches are;extended SNA accounting anchored to the use of exchange values;a complementary accounts network(CAN)that utilizes plural values as supplementary accounts to the SNA system;and wealth accounting that focuses on measures of welfare and wellbeing.The three approaches are complementary and data developed in any one can inform the other two.Conclusions:We contend that CAN offers the most flexibility and opportunities to progress short term support for decision making on environmental issues which are now becoming urgent. | Kerry Turner Tomas Badura Silvia Ferrini | 2019 | Ecosystem Health and Sustainability2019，5，1： | 2 |
| 5 | Removal of Lead,Copper,Zinc and Cadmium from Water Using Phosphate Rock显示文摘摘要:Pb2+ 的移动, Cu2+ ,由自然磷酸盐岩石(FAP ) 上的吸着的 Zn2+and Cd2+from 水的答案被调查。接触时间和起始的金属集中的效果在批方法被检验。从答案的重金属的百分比吸着在 50% 和 99% 之间通常变化。sorbed 金属离子的数量跟随顺序 Cu > Pb > Cd > Zn。重金属固定在重包含金属的磷酸盐的 FAP 谷物和部分溶解和猛冲的表面上被归因于金属离子的两表面 complexation。重金属的低解吸附作用比率进一步作为其他、便宜的材料支持 FAP 的有效性移开有毒的 Pb2+ , Cu2+ , Zn2+and Cd2+from 弄脏水。 | Alessia CORAMI Silvano MIGNARDI Vincenzo FERRINI | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 2 |
| 6 | Cardiac markers and risk stratification: anintegrated approach显示文摘 | Galvani M Ferrini D Ghezzi F | 2001 | Clin Chem Acta2001，311，1： | 1 |
| 7 | Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis 显示文摘 | Ferrini M Magee TR Vernet D | 2001 | Biol Reprod2001，64，3： | 1 |
| 8 | Disorder-induced Losses in Planar Photonic Crystals显示文摘 | FERRINI R LEUENBERGER D HOUDRE R | 2006 | Opt Lett2006，31，10： | 1 |
| 9 | Cancer stem cells: A new paradigm for understanding tumor growth and progression and drug resistance 显示文摘 | Gangemi R Paleari L Orengo AM Cesario A Chessa L Ferrini S | 2009 | Curt Med Chem2009，16，14： | 1 |
| 10 | The gastrointestinal hormone ghrelin modulates inhibitory neurotransmission in deep laminae of mouse spinal cord dorsal horn显示文摘 | Vergnano AM Ferrini F Salio C | | 0，，： | 1 |
| 11 | Morphine hyperalgesia gated through microglia-mediated disruption of neuronal C1- homeostasis显示文摘 | Ferrini F Trang T Mattioli TA | 2013 | Nat Neurosci2013，16，2： | 1 |
| 12 | Evolution of spiral galaxies,4:The thick disk in the solar region as an intermediate collapse phase显示文摘 | PARDI M C FERRINI F | 1995 | The Astrophysical Journal1995，444，： | 1 |
| 13 | L - arginine and phosphodiesterate (PDE) inhibitors counteract fibrosis in the Peyronie' fibrotic plaque and related fibroblast cultures显示文摘 | Valente EGA Vernet D Ferrini MG | 2003 | Nitirc Oxide2003，9，4： | 1 |
| 14 | Natriuretic peptides for risk stratification of patients with acute coronary syndromes显示文摘 | Galvani M Ferrini D Ottani F | 2004 | Eur J Heart Fail2004，6，3： | 1 |
| 15 | 1,25 (OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2) C(12) skeletal muscle cells 显示文摘 | GARCIA L A FERRINI M G NORRIS K C | 2013 | J Steroid Biochem Mol Biol2013，133，： | 1 |
| 16 | Cadmium removal from single-and multi-metal(Cd+Pb+Zn+Cu)solutions by sorption on hydroxyapatite显示文摘 | Corami A Mignardi S Ferrini V | 2008 | Journal of Colloid and Interface Science2008，317，2： | 1 |
| 17 | Hole Depth-and Shape-induced Radiation Losses in Two-dimensional Photonic Crystals显示文摘 | FERRINI R LOMBARDET B WILD B | 2003 | Appl Phys Lett2003，82，7： | 1 |
| 18 | Local insulin infusion stimulates expression of plasminogen activator inhibitor-1 and tissue-type plasminogen activator in normal subjects 显示文摘 | CARMASSI F MORALE M FERRINI L | 1999 | Am J Med1999，107，4： | 1 |
| 19 | Prodromal angina limits infarct size:a role for ischemic preconditioning显示文摘 | Ottani F Galvani M Ferrini D | 1995 | Circulation1995，91，： | 1 |
| 20 | Effect of reclaimed wastewater on the growth and nutrient content of three landscape shrubs 显示文摘 | GORI R FERRINI F NICESE F P | 2000 | Journal of Environmental Horticulture2000，18，2： | 1 |
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