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| 1 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 2 | Argentine Plants as Potential Source of Insecticidal Compounds 显示文摘 | Broussalis A M Ferraro G E Martino V S | 1999 | Journal of Ethnopharm Acology1999，67，： | 1 |
| 3 | Value-based decision environment visio and application 显示文摘 | GORISSEN D QUARANTA E FERRARO M | 2014 | Journal of Aircraft2014，51，5： | 1 |
| 4 | Cytosolic high K (m) 5' - nucleotidase and 5' ( 3' ) - deoxyribonucleotidase in sub- strate cycles involved in nucleotide metabolism显示文摘 | GAZZIOLA C FERRARO P MORAS M | 2001 | J Biol Chem2001，276，9： | 1 |
| 5 | Desmoid-type fibromatosis of the mesentery:report of a sporadic case with emphasis on differential diagnostic problems显示文摘 | Li Destri G Ferraro MJ Calabrini M | 2014 | Case Rep Med2014，2014，85： | 1 |
| 6 | Radiosensitization of Che- motherapy-Refractory, Locally Advanced or Locally Recurrent Breast Cancer with Trastuzumab: A Phase Ⅱ Trial显示文摘 | Horton JK Halle J Ferraro M | 2010 | Int J Ra- diat Oncol Biol Phys2010，76，4： | 1 |
| 7 | Laboratory reference values 显示文摘 | KRATZ A FERRARO M SLUSS P M et el | 2004 | New England Journal of Medicine2004，351，： | 1 |
| 8 | TLR4 up- regulation underpins airway neutrophilia in smok- ers with chronic obstructive pulmonary disease and acute respiratory failure 显示文摘 | Pace E Giarratano A Ferraro M | 2011 | Hum Immunol2011，72，1： | 1 |
| 9 | Assessing the motor status score: a scale for the evaluation of upper limb motor outcomes in pa- tients after stroke 显示文摘 | Ferraro M Demaio JH Krol J | 2002 | Neurorehabil Neural Repair2002，16，3： | 1 |
| 10 | Effects of microcystin-LR on mouse lungs显示文摘 | SOARES R M CAGIDO V R FERRARO R B | 2007 | Toxicon2007，50，3： | 1 |
| 11 | UbcH10 is overexpressed in malignat breast carcinomas显示文摘 | Berlingieri M T Pallante P Sboner A Barbareschi M Bianco M Ferraro A | 2007 | Eur J Cancer2007，43，： | 1 |
| 12 | Human epididymis protein 4 : factors of variation 显示文摘 | Ferraro S Schiumarini D Panteghini M | 2015 | Clin Chim Acta2015，438，： | 1 |
| 13 | Rosuvastatin induced rhab-domyolysis probably via CYP2C9 saturation 显示文摘 | Gallelli L Ferraro M Spagnuolo V | 2009 | Drug Metabol DrugInteract2009，24，1： | 1 |
| 14 | Assessment of intermittent trace element pollution by moss bogs显示文摘 | CESA M BIZZOTTO A FERRARO C | 2006 | Environmental Pollution2006，144，3： | 1 |
| 15 | Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcino- ma cells显示文摘 | Pelaez 1M Kalogeropoulou M Ferraro A | 2010 | Int J Biochem Cell Bioi2010，42，6： | 1 |
| 16 | Biological applications of LbL multilayer capsules: from drug delivery to sensing显示文摘 | Mereato L L D Ferraro M M Baldassarre F | 2014 | Advances in Colloid and Interface Science2014，207，0： | 1 |
| 17 | Changing strategies of lung biopsies in diffuse lung diseases:the impact of video-assisted thoracoscopy显示文摘 | Ferraro G Barbieri B | 1998 | Eur Respir J1998，11，1： | 1 |
| 18 | Effect of defoliation on grass growth显示文摘 | Ferraro D O Oesterheld M | 2002 | A quantitative review Oikos2002，98，： | 1 |
| 19 | TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure显示文摘 | PACE E GIARRATANO A FERRARO M | 2011 | Human Immunology2011，72，1： | 1 |
| 20 | Assessing the motor status score:a scale for the evaluation of upper limb motor outcomes in patients after stroke显示文摘 | Ferraro M Demaio JH Krol J | 2002 | Neurorehabil Neural Repair2002，16，3： | 1 |
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