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| 1 | 青少年运动员早期专业化训练的生理学问题显示文摘青少年运动员是运动员的一个特殊群体 ,正面临着身体的生长发育和运动能力提高的双重压力。如何在不影响身体正常发育的同时又能在运动能力及身体素质等方面得到充分的发展 ,始终是青少年运动员在运动训练中亟待解决的问题。研究对处在发育期青少年的生理特点、运动能力及训练等问题进行了探讨 。 | 金爱晶 Geraldine Naughton 王耀光 John Carlson Clermont Ferrand | 2000 | 体育科学2000，20，6： | 16 |
| 2 | αV integrin:A new gastrin target in human pancreatic cancer cells显示文摘AIM:To analyse αV integrin expression induced by gas-trin in pancreatic cancer models. METHODS:αV integrin mRNA expression in human pan-creatic cancer cells was analysed using a 'cancer genes' array and confirmed by real-time reverse transcription-polymerase chain reaction (PCR). Western blotting and semi-quantitative immunohistochemistry were used to examine protein levels in human pancreatic cancer cell lines and pancreatic tissues, respectively. The role of αV integrin on gastrin-induced cell adhesion was examined using blocking anti-αV integrin monoclonal antibodies. Adherent cells were quantified by staining with crystal violet.RESULTS: Using a 'cancer genes' array we identified αV integrin as a new gastrin target gene in human pancreatic cancer cells. A quantitative real-time PCR approach was used to confirm αV integrin gene expression. We also demonstrate that Src family kinases and the PI 3-kinase, two signalling pathways specifically activated by the CCK-2 receptor (CCK2R), are involved in gastrin-mediated αV integrin expression. In contrast, inhibition of the ERK pathway was without any effect on αV integrin expression induced by gastrin. Our results also show that gastrin modulates cell adhesion via α V integrins. Indeed, in vitro adhesion assays performed on fibronectin show that gastrin significantly increases adhesion of pancreatic cancer cells. The use of blocking anti-αV integrin monoclonal antibodies completely reversed the increase in cell-substrate adhesion induced by gastrin. In addition, we showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, leads to the overexpression of αV integrin. This process may contribute to pancreatic tumour development observed in these transgenic animals. CONCLUSION:αV integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion. | Celine Cayrol Claudine Bertrand Aline Kowalski-Chauvel Laurence Daulhac Elizabeth Cohen-Jonathan-Moyal Audrey Ferrand Catherine Seva | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 3 | 儿童颅咽管瘤质子和光子治疗的剂量学比较显示文摘目的:对3例儿童颅咽管瘤进行剂量学比较,以探讨质子在儿童颅咽管瘤放疗中的潜在优越性。方法:靶区肿瘤照射剂量为55 Gy。每例患者分别作单纯光子、光子和质子混合射线以及单纯质子的治疗计划,治疗方法均为三维适形治疗;应用适形指数以量化地比较3种治疗计划对靶区的剂量覆盖和正常组织的照射容积和剂量。结果:3种治疗计划均达到满意的靶区剂量覆盖,92%~100%的PTV在处方剂量95%的范围内。质子治疗的运用使得正常脑组织、脑干、大脑颞叶和内耳的剂量显著下降。当肿瘤与视交叉有少许间隙时,质子治疗可以降低视交叉的平均剂量和最低剂量。单纯质子体现出较混合射线更强的优越性。单纯光子、混合射线和单纯质子的适形指数分别为0.631、0.784和0.848,即质子治疗提供的高剂量区曲线分布更符合PTV的形状。结论:在保证靶区剂量的基础上,质子的应用普遍减少了颅内正常组织的照射,并在部分患者中提供了剂量提升的可能性。 | 陈佳艺 Régis FERRAND Léontine RABARIJAONA Jean-Louis HABRAND | 2003 | 中国癌症杂志2003，13，4： | 3 |
| 4 | Mechanism for Src activation by the CCK2 receptor:Patho-physiological functions of this receptor in pancreas显示文摘瞄准:调查在活体内, CCK2 受体(CCK2R ) 是否调整蛋白质,知道在房间增长和癌症开发和分析在试管内起一个关键作用导致 Src 激活的分子的机制;特别地,那在这激活被含有在 CCK2R 顺序以内识别领域。方法:Src 和英皇家空军之阶级最低之兵的表示和激活是学习在活体内使用免疫荧光和西方污点的技术。我们使用了从在胰腺的腺泡表示了 CCK2R 的野类型或 Elas-CCK2 老鼠导出的胰腺的纸巾,显示了增加的胰腺的生长并且开发了肿瘤前损害。短暂地表示内长的 CCK2R 或 COS-7 房间的胰腺的肿瘤房间线 AR4-2J 有野类型或变异的 CCK2R 的 transfected 被用作在试管内模型学习 Src 激活的机制。Src 激活被在试管内激酶试金测量,由用 anti-phospho-ERK 抗体和在由 MTT 的导致 gastrin 的房间增长的 Src 的参与的西方的污点的英皇家空军之阶级最低之兵激活测试。结果:我们出现了因为在 Elas-CCK2 鼠标的胰的指向的 CCK2R 表达式,导致了 Src 和 ERK 小径的激活。Src 被激活由在胰腺的弦音器的 CCK2R 的 ERK 小径在上游口头的房间并且贡献了增生的效果由这受体调停了。在试管内结果证明由 CCK2R 的 Src/ERK 小径的激活要求了 NPXXY 主题,在第 7 transmembrane 领域的结束在 CCK2R 顺序以内定位了,并且建议了在这机制的 Gq 的通常认为的角色。结论:由 CCK2R 的 Src/ERK 小径的解除管制可能代表贡献房间增长,肿瘤前损害的形成和胰腺的肿瘤开发的早步。 | Audrey Ferrand Sebastien Vatinel Aline Kowalski-Chauvel Claudine Bertrand Chantal Escrieut Daniel Fourmy Marlene Dufresne Catherine Seva | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 5 | Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells显示文摘瞄准:为了调查 Src, JAK2 和 phosphatidylinositol 3-kinase (PI3K ) 小径是否涉及人的结肠的瘤房间的增长,由扩大 glycine 的促胃液素导致了(G-gly ) ,先锋在 ated 促胃液素中并且到成熟阐明在响应这肽的这三家族 ases 之间的分子的相互作用。方法:用人的结肠的瘤,房间作为一个模型衬里 HCT116,我们首先测量了 PI3K, p60-Src 和 JAK2 的激活响应 G-gly 由在试管内激酶试金。然后,我们由 MTT 测试在 G-gly-induced 房间增长调查了这些家族 ases 的参与。结果:G-gly,刺激在 HCT116 导致了 p60-Src, JAK2 和 PI3K 激活。不同小径涉及房间导致了由的人的结肠癌的增长 G-gly。而且,我们发现 Src 和 JAK2 对由这肽的 PI3K 规定必要。然而,我们没发现在二酷氨酸家族 ases 之间的任何串音。结论:我们的结果建议 p60-Src/PI3K 和 JAK2/PI3K 小径独立地行动调停人的结肠的瘤房间上的 G-gly 增生的的效果。 | Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva Julie Pannequin | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 6 | Mechanism for mutational inactivation of the tumor suppressor Smad2显示文摘 | Prunier G Ferrand N Frottier B | 2001 | Mol Cell Biol2001，21，： | 1 |
| 7 | Macroporous chiral ruthenium porphyrin polymers:a new solid-phase material used as a device for catalytic asymmetric carbene transfer显示文摘 | FERRAND Y LE MAUX P SIMONNEAUX G | | 0，，： | 1 |
| 8 | Error diagnosis in logic programming显示文摘 | Ferrand G | | 0，，03： | 1 |
| 9 | Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting显示文摘 | Contassot E Ferrand C Angonin R | 2000 | Transplantation2000，69，4： | 1 |
| 10 | Highly luminescent,visible-emitting lanthanide macrocyclic chelates stable in water and derived from the cyclen framework显示文摘 | Zucchi G Ferrand A Scopelliti R | 2002 | Inorg Chem2002，41，9： | 1 |
| 11 | Withholding and withdrawal of life supporting intensive care units in Franee:A prospective study French LATAREA Group 显示文摘 | Ferrand E Robea R Ingrand P | 2001 | Lancet2001，357，9249： | 1 |
| 12 | Harmonics-to-noise ratio:an index of voical aging显示文摘 | Carole T Ferrand CT | 2002 | Journal of Voice2002，16，： | 1 |
| 13 | The oncoprotein Ski acts as an antagonist of transforming gowth factor-beta signaling by suppressing Smad 2 phosphorylation显示文摘 | Prunier C Pessah M Ferrand N | 2003 | J Biol Chem2003，278，26： | 1 |
| 14 | Thioflavine-T and Congo Red reveal the polymorphism of insulin amyloid fibrils when probed by polarization-resolved fluorescence microscopy显示文摘 | Duboisset J Ferrand P He W | 2013 | J Phys Chem B2013，117，3： | 1 |
| 15 | High levels of nucleotide diversity in the European rabbit ( Oryctolagus cuniculus) SRY gene 显示文摘 | GERALDES A ROGEL-GAILLARD C FERRAND N | 2005 | Animal Genetics2005，36，4： | 1 |
| 16 | Neutron diffraction study of the ferrimagnetic ilmenite(nickel manganese oxide (NiMnO3)显示文摘 | Pernet M Joubert J C Ferrand B | 1975 | Solid State Communications1975，16，5： | 1 |
| 17 | Immunohistological detection of methionine-enkephalin -like and endorphin-like material in the digestive tract and in the nervous system of the mussel:Mytilus edulis L显示文摘 | Andersen A C L'Hermite A Ferrand R | 1986 | Gen Comp Endocrinol1986，62，1： | 1 |
| 18 | c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad 3 transcriptional activity显示文摘 | Dennler S Prunier C Ferrand N | | 0，，： | 1 |
| 19 | Electrospun nanofibrous 3D scaffold for bone tissue engineering显示文摘 | Eap S Ferrand A Palomares CM | 2012 | Biomed Mater Eng2012，22，13： | 1 |
| 20 | Water diffusion in the simulated French nuclear waste glass SON68 contacting silica rich solutions: Experimental and modeling 显示文摘 | Ferrand K Abdelouas A Grambow B | 2006 | Journal of Nuclear Materials2006，355，： | 1 |
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