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您的检索式：作者名="Fernando Navarrete"
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| 1 | Incidental differentiated thyroid carcinoma is less prevalent in Graves’ disease than in multinodular goiter显示文摘 | Eider Pascual Corrales Rosa Maria Príncipe Sara Laguna Muro Fernando Martínez Regueira Juan Manuel Alcalde Navarrete Francisco Guillén Grima Juan Carlos Galofré | 2012 | Endocrinología y nutrición (English Edition)2012，，3： | 1 |
| 2 | TOPLESS promotes plant immunity by repressing auxin signaling and is targeted by the fungal effector Naked1显示文摘In plants,the antagonism between growth and defense is hardwired by hormonal signaling.The perception of pathogen-associatedmolecularpatterns(PAMPs)frominvadingmicroorganismsinhibits auxin signalingand plant growth.Conversely,pathogens manipulate auxin signaling to promote disease,but how this hormone inhibits immunity is not fully understood.Ustilago maydis is a maize pathogen that induces auxin signaling in its host.We characterized a U.maydis effector protein,Naked1(Nkd1),that is translocated into the host nucleus.Through its native ethylene-responsive element binding factor-associated amphiphilic repression(EAR)motif,Nkd1 binds to the transcriptional co-repressors TOPLESS/TOPLESS-related(TPL/TPRs)and prevents the recruitment of a transcriptional repressor involved in hormonal signaling,leading to the derepression of auxin and jasmonate signaling and thereby promoting susceptibility to(hemi)biotrophic pathogens.A moderate upregulation of auxin signaling inhibits the PAMP-triggered reactive oxygen species(ROS)burst,an early defense response.Thus,our findings establish a clear mechanism for auxin-induced pathogen susceptibility.Engineered Nkd1 variants with increased expression or increased EAR-mediated TPL/TPR binding trigger typical salicylic-acid-mediated defense reactions,leading to pathogen resistance.This implies that moderate binding of Nkd1 to TPL is a result of a balancing evolutionary selection process to enable TPL manipulation while avoiding host recognition. | Fernando Navarrete Michelle Gallei Aleksandra EKornienko Indira Saado Mamoona Khan Khong-Sam Chia Martin A.Darino Janos Bindics Armin Djamei | 2022 | Plant Communications2022，3，2： | 1 |
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