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| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 3 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 4 | Acute effects of physical exercise in type 2 diabetes: A review显示文摘The literature has shown the efficiency of exercise in the control of type 2 diabetes(T2D), being suggested as one of the best kinds of non-pharmacological treatments for its population. Thus, the scientific production related to this phenomenon has growing exponentially. However, despite its advances, still there is a lack of studies that have carried out a review on the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in individuals with T2 D, not to mention that in a related way, these themes have been very little studied today. Therefore, the aim of this study was to organize and analyze the current scientific production about the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in T2 D individuals. For such, a research with the following keywords was performed:-exercise; diabetes and post-exercise hypotension; diabetes and excess post-exercise oxygen consumption; diabetes and acute effects in PUBMED, SCIELO and HIGHWIRE databases. From the analyzed studies, it is possible to conclude that, a single exercise session can promote an increase in the bioavailability of nitric oxide and elicit decreases in postexercise blood pressure. Furthermore, the metabolic stress from physical exercise can increase the oxidation of carbohydrate during the exercise and keep it, in high levels, the post exercise consumption of O2, this phenomenon increases the rate of fat oxidation during recovery periods after exercise, improves glucose tolerance and insulin sensitivity and reduces glycemia between 2-72 h, which seems to be dependent on the exercise intensity and duration of the effort. | Ricardo Yukio Asano Marcelo Magalhes Sales Rodrigo Alberto Vieira Browne José Fernando Vila Nova Moraes Hélio José Coelho Júnior Milton Rocha Moraes Hebert Gustavo Simoes | 2014 | World Journal of Diabetes2014，5，5： | 8 |
| 5 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 6 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 7 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 8 | 基于神经网络和光流场的嵌入式高速目标识别与跟踪(英文)显示文摘研究了面向嵌入式硬件平台的高速视频图像处理与高速目标跟踪算法。基于神经网络的光流场算法能有效减少程序对硬件系统的内存要求和运算要求,该算法能够比传统算法更加容易的应用于以DSP(数字信号处理)芯片为核心的嵌入式硬件平台中。首先设计了一个基于Hopfield神经网络控制器的自适应滤波器,以图像信噪比为控制指标,对需进行目标识别的视频图像进行图像预处理;然后,利用补偿模糊神经网络控制器对光流场计算方法进行优化,这是一种通过参数控制平滑度实现的平均速度的角度误差和标准角误差的CFNN(补偿模糊神经网络)控制器识别跟踪算法。微机仿真及嵌入式系统试验结果均表明:该算法能够在同等条件下显著提高目标辨别与跟踪能力,显示其具有较高的有效性和实用性。 | 苏金泷 HERBERT H C IU FERNANDO T | 2015 | 中国公路学报2015，28，11： | 2 |
| 9 | Effect of the hydrophilic size on the structural phases of aqueous nonionic Gemini surfactant solutions显示文摘 | Nieh M P Kumar S K Fernando R H | 2004 | Langmuir2004，20，21： | 1 |
| 10 | Covalent grafting of phenylphonate groups onto layered silica derived from in situ-leached chrysotile fibers显示文摘 | Fernando Wypych Wido H Schreiner Ney Mattoso | 2003 | J Mater Chem2003，13，2： | 1 |
| 11 | Improving collaborativefiltering recommender systems results and performance usinggenetic algorithms显示文摘 | Jesus B Fernando 0 Antonie H | 2008 | Knowledge-Based Systems2008，24，： | 1 |
| 12 | Possible differences in the regenerative roles played by thioltransferase and thioredoxin for oxidativeely damaged proteins显示文摘 | YOSHITAKE S NANRI H FERNANDo M R | 1994 | Biochem1994，116，1： | 1 |
| 13 | The cellular location of Cu in lichens and its effects on mernbrance integrity and chlorophyll fluorescence显示文摘 | CRISTIAN B DERNIS H B FERNANDO C | 1997 | Environ&Exper Batany1997，38，： | 1 |
| 14 | Grafting of phenylarsonic and 2-nitrophenol-4-arsonic acid onto disordered silica obtained by selective leaching of brucite-like sheet from chrysotile structure显示文摘 | Fernando Wypych Wido H Schreiner Emerson Richard Jr | 2004 | J Colloid Interf Sci2004，276，1： | 1 |
| 15 | Determination of formation constants of copper(Ⅱ) complexes of (hydroxyethylidene)diphosphonic acid with a solid state cupric ion-selective electrode 显示文摘 | WADA H FERNANDO Q | 1971 | Analytical Chemistry1971，43，6： | 1 |
| 16 | Fault Location Using Wavelets显示文摘 | Fernando H M Abur A | 1998 | IEEE Trans on Power Delivery1998，13，4： | 1 |
| 17 | Thioredoxin regenerates proteins inactivated by oxidative stress in endothelial ceils 显示文摘 | Fernando MR Nanri H Yoshitake S | 1992 | Eur J Biochem1992，209，： | 1 |
| 18 | Disturbance decoupled observers for systems with unknown inputs 显示文摘 | Trinh H Tran T D Fernando T | 2008 | IEEE Transactions on Automatic Control2008，53，10： | 1 |
| 19 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 20 | Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer显示文摘 | Fernando H S Davies S R Chhabra A | 2007 | Oncology2007，73，56： | 1 |
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