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| 1 | Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer显示文摘Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone marrow.However,the contribution of SPARCduring the early stages of tumor progression remains unclear.In this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason score.Through stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ntin.Moreover,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell proliferation.Our results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells. | Fernanda Lopez-Moncada Maria Jose Torres Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，6： | 5 |
| 2 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 3 | Neurophysiological basis of penile erection显示文摘阴茎勃起包含在中央 nervoussystem 之间的一个复杂相互作用,本地 factors.It 是调制由的一个神经与血管的事件心理并且氮的氧化物的 hormonalfactors.The 发现(没有)作为为识别生理的位于下面的重要机制和 pathophysiological eventsin 的一个细胞间的送信人或 neurotransmitter pavedthe 方法阴茎,除了提供,为新治疗学的发展的知识基于分子和房间相互作用的 ona | Fernanda B M PRIVIERO Romulo LEITE R Clinton WEBB Cleber E TEIXEIRA | 2007 | Acta Pharmacologica Sinica2007，28，6： | 3 |
| 4 | Modeling respiration rate of fresh fruits and vegetable for modified atmosphere packages: a review显示文摘 | Susana C F Fernanda A R Jeffrey K B | 2002 | Journal of Food Engineering2002，52，6： | 1 |
| 5 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 6 | Observing the performance of distribution systems with embeded generators显示文摘 | CIRIC R M PADILHA-FELTRIN A IARA FERNANDA EDD | 2004 | European Trans on Electrical Power2004，14，6： | 1 |
| 7 | Additional 3- nitropropanoyl esters of glucose from lndigoferasuffruticosa (Leguminosae) 显示文摘 | Wahnir S G Fernanda R Barison A | 2003 | Biochem Syst Ecol2003，31，2： | 1 |
| 8 | The response of surf-zone phytoplankton to nutrient enrichment(Cassino Beach,Brazil)显示文摘 | Fernanda R P Clarisse O | 2012 | Journal of Experimental Marine Biology and Ecology2012，，432433： | 1 |
| 9 | Modeling res- piration rate of shredded Galena kale for development of modi- fied atmosphere packaging 显示文摘 | Susana C F Fernanda A R O Jesus M F | 2002 | Journal of Food Engineering2002，54，4： | 1 |
| 10 | Electromagnetic Stimulation Combined with Aloe vera Increases Collagen Reorganization in Burn Repair显示文摘 | Sofia Poletti Leticia D. Lucke Fernanda O Bortolazzo Renata M. Acunha Marcos G. Mattos Femanda OG. Gaspi Thiago A. M. Andrade Maria Esmeria C. Amaral Andrea A .Aro Edson R Pimentel Marcelo AM. Esquisatto Fernanda A. S. Mendonga Glaucia M. T. Santos | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 11 | Characterization of ergocalciferol loaded solid lipid nanoparticles显示文摘 | PATEL M R MARTIN-GONZALEZ S FERNANDA M | 2012 | Journal of Food Science2012，77，1： | 1 |
| 12 | Mathematical modeling of the kinetic of quality deterioration of intermediate moisture content banana during storage显示文摘 | Yan Zheng - yong Sousa - Gallagher Maria J Fernanda A R Oliveira | 2008 | Journal of Food Engineering2008，84，3： | 1 |
| 13 | Modelling 02 and CO2 Exchange for Development of Perforation-medi- ated Atmosphere Packaging显示文摘 | SUSANA C F FERNANDA A R ISABEL B M | 2000 | Journal of Food Engineer- ing2000，43，： | 1 |
| 14 | Modelling respiration rate of shredded Galega kale for development of modified atmosphere packaging 显示文摘 | Susana C F Fernanda A R O Jesus M F | 2002 | Journal of Food Engineering2002，54，4： | 1 |
| 15 | Extending shelf life of shredded Galega kale using a modified atmosphere package显示文摘 | Susana C F Fernanda A R O Jesus M F | 2004 | Electronic Journal of Environmental Agricultural and Food Chemistry2004，3，5： | 1 |
| 16 | Free radical scavenging of grape pomace extracts from cabernet sauvingnon (Vitis vinifera)显示文摘 | LUANDA M A S FERNANDA V PEDROSA R | 2008 | Bioresource Technology2008，99，17： | 1 |
| 17 | Mycophenolate mofetil treatment in two children with severe polyarteritis nodosa refractory to immunosuppressant drugs显示文摘 | Fernanda F Serena C Giustina R | 2012 | Rheumatol Int2012，32，7： | 1 |
| 18 | Shrinkage and porosity of banana, pineapple and mango slices during air-drying显示文摘 | Zhengyong Yan Maria J Sousa-Gallaghter Fernanda A R Oliveira | 2008 | Journal of Food Engineering2008，84，3： | 1 |
| 19 | Melanoma metastasis to the gastric mucosa preceded by guillain- barr6 as aparaneoplastic? syndrome 显示文摘 | Kraft Rovere R Pires de Souza ME Fernanda Hilgert S | 2013 | Gastrointest CancerRes2013，6，56： | 1 |
| 20 | Micropulse diode laser treatment for chronic central serous chorioretinopathy: a randomized pilot trial 显示文摘 | Luiz R Fernanda PM Daniel L | 2013 | Ophthalmic Surg Lasers Imaging Retina2013，44，5： | 1 |
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