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| 1 | Homoeology of rye chromosome arms to wheat显示文摘 | Naranjo T Fernández-Rueda P | 1991 | Theor Appl Genet1991，82，： | 1 |
| 2 | Motion features to enhance scene segmentation in active visual attention显示文摘 | López M T Fernández-Caballero A Fernández M A | 2006 | Pattern Recognition Letters2006，27，5： | 1 |
| 3 | Effects of chronic acarbose treatment on adipocyte insulin responsiveness, serum levels of leptin and adiponectin and hypothalamic NPY expression in obese diabetic Wistar rats显示文摘 | Perez C Fern a ndez-Agull o T De Sol i s AJ | 2008 | Clin Exp Pharmacol Physiol2008，35，3： | 1 |
| 4 | Characterisation of Gd202S:Pr phosphor screens for water window X -ray detection 显示文摘 | Fern G Ireland T Silver J | 2009 | Nucl Instrument Meth A2009，600，： | 1 |
| 5 | Preparation of hydrolysates from tobacco stalks and ethanolic fermentation by Saccharomyces cerevisiae显示文摘 | Martín C Fernández T García R | 2002 | World Journal of Microbiology&Biotechnology2002，18，9： | 1 |
| 6 | Reporting incidents of Violence and aggression towards NHS staff显示文摘 | FERNS T CHOJNACKA I | 2005 | Nurs Stand2005，19，38： | 1 |
| 7 | Surface-Modified CdSe Quantum Dots for the Sensitive and SelectiveDetermination of Cu(II)in Aqueous Solutions by Luminescent Measurements显示文摘 | Fernández-Argüelles M T Jin W J Costa-Fernández J M | 2005 | Analytica Chimica Acta2005，549，12： | 1 |
| 8 | Role of Wettability and Nanoroughness on Interactions between Osteoblast and Modified Silicon Surfaces显示文摘 | PADIAL-MOLINA M GALINDO-MORENO P FERN~t NDEZ-BARBERO J E | 2011 | Acta Biomater2011，7，2： | 1 |
| 9 | Assessment of synthetic chimeric multiple antigenic peptides for diagnosis of GB virus C infection显示文摘 | G(O)MARA M J FERN(A)NDEZ L P(E)REZ T | 2010 | Anal Biochem2010，396，1： | 1 |
| 10 | Rapid ischemic cell death in immature oligedendrocytes:a fatal glutame release feedback loop显示文摘 | Fern R M(o)ller T | 2000 | J Neurosci2000，20，1： | 1 |
| 11 | Ba- sic aspects of musculoskeletal pain: from acute to chronic pain显示文摘 | Arendt-Nielsen L Fern(mdez-de-Las-Pefias C Graven-Nielsen T | 2011 | J Man Manip Ther2011，19，4： | 1 |
| 12 | Arbuscular mycorrhizal symbiosis decreases strigolactone production in tomato 显示文摘 | López-Ráez J A Charnikhova T Fernández I | 2011 | Journal of Plant Physiology2011，168，7： | 1 |
| 13 | Frequency and antimicrobi- al sensitivity of ureaplasma urealytieum and mycoplasma hominis in patients with vaginal discharge 显示文摘 | Díaz L Cabrera LE Fernández T | 2013 | Medicc Rev2013，15，4： | 1 |
| 14 | Clear lens extraction for the correction of high myopia显示文摘 | Fernández-Vega L Alfonso JF Villacampa T | | 0，，12： | 1 |
| 15 | Dialyzable Leukocyte Extract differentially regulates the production of TNFα,IL-6,and IL-8 in bacterial componentactivated leukocytes and endothelial cells显示文摘 | Ojeda MO Veer CV T Fern Ndez Ortega CB | 2005 | Inflammation Res2005，54，2： | 1 |
| 16 | Visual function after implantation of an aspheric bifocal intraocular lens显示文摘 | Alfonso JF Fernández-Vega L Amhaz H Montes-Mico R Valcar-cel B Ferrer-Blasco T | 2009 | J Cataract Refract Surg2009，35，5： | 1 |
| 17 | Metabolic syndrome, adiponectin, and cardiovascular risk in spain(The Segovia Study) :Impact of consensus societies criteria显示文摘 | Corbat n A A Mart nez L M T Fern ndez P C | 2013 | Metab Syndr Relat Disord2013，，： | 1 |
| 18 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 19 | Photoactivated luminescent CdSe quantum dotsas sensitive cyanide probes in aqueous solutions 显示文摘 | JIN W J’FERN NDEZ -ARG ELLES M T COSTA -FERNNDEZ J M | 2005 | ChemicalCommunications2005，，7： | 1 |
| 20 | Surface -modified CdSe quantum dots forthe sensitive and selective determination of Cu(11) in aqueoussolutions by luminescent measurements 显示文摘 | FERN NDEZ -ARG ELLES M T JIN W J COSTA -FERNNDEZ J M | 2005 | Analytica ChimicaActa2005，549，12： | 1 |
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