|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Usefulness of duodenal biopsy during routine upper gastrointestinal endoscopy for diagnosis of celiac disease显示文摘瞄准:在一张成年西班牙的人口在平淡的上面的胃肠的内视镜检查法期间在十二指肠的活体检视性能描述趋势,并且在临床的实践为乳糜泻的诊断分析它的值。方法:在当承担上面的胃肠的内视镜检查法时,执行的十二指肠的活体检视的 15 年趋势(1990 ~ 2004 ) 被学习。我们与贫血症或长期的腹泻在全面的组,并且在亚群分析了乳糜泻的流行。结果:十二指肠的活体检视在 13 678 上面的胃肠的内视镜检查法(7.6%) 中的 1033 个被执行;这的使用的增加在学习时期上被观察(1.9% 在 1990-1994, 5% 在 1995-1999 并且 12.8% 在 2000-2004 ) 。乳糜泻在 22 个病人(2.2%) 被诊断,这比在男人在女人是更经常的(3% 和 1% 分别地) 。十四从 514 (2.7%) 有贫血症的病人, 12 从 141 (8.5%) 与长期的腹泻并且 8 (19%) 从 42,与贫血症,正长期的腹泻有乳糜泻。一个古典临床的演讲在 55% 盒子中被观察, 23% 病人联系了疱疹样皮炎和 64% 介绍贫血症;9% 被家庭屏蔽诊断并且 5% 由秘密成员基因 hypertransaminasaemia。结论:在成年人在平淡的上面的胃肠的内视镜检查法期间承担的十二指肠的活体检视,逐渐地被合并了到临床的实践,并且是为在象有贫血症或长期的腹泻的那些那样的高风险组的乳糜泻的诊断的一个有用工具。 | S Riestra F Domínguez E Fernández-Ruiz E García-Riesco R Nieto E Fernández L Rodrigo | 2006 | World Journal of Gastroenterology2006，12，31： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | The role of neuroimmunomodulation in Alzheimer′s disease显示文摘 | MACCIONI R B ROJO L E FERNNDEZ J A | 2009 | Ann N Y Acad Sci2009，1153，： | 1 |
| 4 | Small increases in extravascular lungwater are accu- rately detected by transpulmonary thermodilution 显示文摘 | Fern Adez - Mond jar E Rivera - Fern Adez R Garc a - Del- gadoM | 2005 | J Trauma2005，59，： | 1 |
| 5 | Evolution of acid phosphatase activity of honeys from different climates显示文摘 | ALONSO-TORRE S R CAVIA M M FERNNDEZ-MUIO M A | 2006 | Food chemistry2006，97，4： | 1 |
| 6 | NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury 显示文摘 | Salter MG Fern R | 2005 | Nature2005，438，： | 1 |
| 7 | A trimeric protein complex functions as a synaptic chaperone machine显示文摘 | Tobaben S Thakur P Fernández-Chacón R | | 0，，： | 1 |
| 8 | Carbon contents and respiration rates of aggregate size fractions under no-till and conventional tillage显示文摘 | Fernández R Quiroga A Zorati C Noellemeyer E | 2010 | Soil Till Res2010，109，2： | 1 |
| 9 | Analysis of tantalum implants used for avascular necrosis of the femoral head:a review of five retrieved specimens显示文摘 | Fernández-Fairen M Murcia A Iglesias R | 2012 | J Appl Biomater Funct Mater2012，10，1： | 1 |
| 10 | Cloud point extraction,preconcentration and spectrophotometric determination of erbium(Ⅲ)-2-(3,5-dichloro-2-pyridylazo) -5-Dimethyla minophenol显示文摘 | Silva M F Fern á ndez L Olsina R | 1997 | Anal Chim Acta1997，，342： | 1 |
| 11 | The 2araventricular nucleus of hypothalamus mediates the pressor response to noradrenergic stimulation of the medial prefrontal cortex in unanesthetized rats显示文摘 | FERN ANDES K B TAVARES R F PELOSI G G | 2007 | Neumscience Letters2007，426，2： | 1 |
| 12 | A ‘first loop' linear epitope accessible on native hepatitis B surface antigen that persists in the face of 'second loop' immune escape显示文摘 | Ijaz S Ferns R B Tedder R S | 2003 | J Gen Virol2003，84，： | 1 |
| 13 | Identification of endothelin receptor subtype (ETB) in human cerebral cortex using subtype selective ligands显示文摘 | Fernández-Durango R de Juan JA Zimman H | | 0，，04： | 1 |
| 14 | Small increases in extravascular lung water are accurately detected by transpulmonary thermodilution显示文摘 | Fernández-Mondéjar E Rivera-Fernández R García-Delgado M | | 0，，06： | 1 |
| 15 | Synergistic effects of betaine and conjugated linoleic acid on the growth and carcass composition of growing Iberian pigs1,2显示文摘 | Fernández-Fígares I Conde-Aguilera J A Nieto R | 2008 | Journal of Animal Science2008，86，1： | 1 |
| 16 | Tox- icity evaluation of single and mixed antifouling biocides measured with acute toxicity bioassays 显示文摘 | Fern ndez-Alba A R Hernando M D Piedra L | 2002 | Anal Chim Ac- ta2002，456，： | 1 |
| 17 | Evolution of acid phosphatase activity of honeys from different climates显示文摘 | ALONSO-TORRE S R CAVIAA M M FERN M A | 2006 | Food Chem2006，97，： | 1 |
| 18 | The Vila de Cruces Ophiolite:a remnant of the early Rheic Ocean in the Variscan suture of Galicia (Northwest Iberian Massif)显示文摘 | Arenas R Martínez Catalán J.R Sánchez Martínez S Fernández-Suárez J Andonaegui P Pearce J.A Coffu F | | 0，，： | 1 |
| 19 | Optimization of a comprehensive two-dimensional normal-phase and reversed-phase liquid chromatography system显示文摘 | Dugo P Fernández M M R Cotroneo A | 2006 | J Chromatogr Sci2006，44，9： | 1 |
| 20 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员