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| 1 | Effect of point application on chronic obstructive pulmonary disease in stationary phase and effects on pulmonary function:A systematic evaluation of randomized controlled trials显示文摘OBJECTIVE:To evaluate clinical efficacy of point application or adjuvant therapy on chronic obstructive pulmonary disease in stationary phase and effects on pulmonary functions.METHODS:Computer retrieved CNKI,VIP,CBM and other databanks and manual operations retrieved correlative literatures to find randomized controlled trials(RCTs) about comparison between point application or adjuvant therapy and no-point-applications for treatment of chronic obstructive pulmonary disease in stationary phase in China.RevMan 5.0 software was used for Meta analysis.RESULTS:Among 3481 cases in the inclusive 32 RCTS,1780 cases were in the test group and 1701 cases in the control group.Meta analysis indicated:1) clinical efficacy:the groups containing point application therapy all were better than the groups of no-point-application;2) force vital capacity(FVC):There was no statistically significant difference between the group of point application plus Western Medicine and the Western Medicine group;3) force expiratory volume 1(FEV1):The groups containing point application therapy were better than the no-point-application;4) FEV1%:the groups of point application plus Western Medicine were better than the Western Medicine groups;5) FEV1/FVC:there was a significant difference between the group of point application plus Chinese drugs and the group of Chinese drug.CONCLUSION:Point application can increase clinical efficacy of chronic obstructive pulmonary disease in stationary phase in varying degrees,and different combinations of point application with Chinese drugs or Western Medicines have incomplete same actions in improvement of pulmonary function and therapeutic effect. | Fengsen Li Zhen Gao Jing Jing Dan Xu Halmurat.Upur | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 12 |
| 2 | Efficacy of Yiqigubiao pill on chronic obstructive pulmonary disease in rats with the disease induced by lipopolysaccharide and cigarette-smoke fumigation显示文摘OBJECTIVE:To investigate the efficacy of Yiqigubiao pill(YQGB)on chronic obstructive pulmonary disease(COPD)in rats with the COPD induced by lipopolysaccharide(LPS)and cigarettesmoke fumigation.METHODS:In this study,six groups of rats were set up,including control group,model group,positive control group(aminophylline)and YQGB(high,medium and low doses)groups.Tracheal injection of lipopolysaccharide(LPS)and cigarette-smoke fumigation induced COPD in rats.The general condition,incubation period and coughing times,lung function,level of inflammatory factors,leukocyte condition and pathological changes of bronchus and lung tissue were observed in rats of each group.RESULTS:In the COPD rats,the latent period of coughing was shortened and the cough frequency was increased significantly;the pulmonary function was significantly decreased,which was manifested by the increased lung tissue resistance and respiratory system resistance,and the decreasing percentage of forced expiratory volume and forced expiratory volume in the 0.3 s(FEV0.3/FVC);the contents of tumor necrosis factor-alpha(TNF-α)and interleukin-4 in serum were obviously increased,and the NEUT%in bronchoalveolar lavage fluid was significantly increase.YQGB could obviously prolong the latent period of cough,and reduce the cough frequency and the content of TNF-αin serum.YQGB can also significantly reduce respiratory resistance and increase FEV0.3/FVC value.The results of histopathology showed that YQGB significantly reduced the pathological changes of tracheal mucosa and lung caused by COPD.YQGB obviously increased level of AQP1,which was down-regulated in the COPD rats.CONCLUSION:YQGB could significantly improve the pulmonary function,reduce inflammation and alleviate lung and bronchial diseases in the COPD rats. | Jiang Lin Li Fengsen Sun Jianhui Huo Hairu Li Xiaoqin Li Hongmei | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 6 |
| 3 | Effects of lead exposure on placental cellular apoptosis and endoplasmic reticulum stress in rats显示文摘 | Wang Yunying Hu Haiyan Li Hong Ma Haiyan Xu Fengsen Qu Baoming | 2014 | Chinese Medical Journal2014，，9： | 4 |
| 4 | Expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease with a cold-dryness symptom pattern显示文摘OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and smoking.METHODS: The COPD model was established with an elastase dose into the trachea combined with exposure to smoking; the COPD model cold-dryness symptom pattern was further developed by exposure to a cold, dry environment. After 90 days,pathologic lung sections, inflammatory cytokine levels(measured by enzyme linked immunosorbent assay), m RNA and protein expression of mucus-associated proteins and aquaporins(measured by real-time polymerase chain reaction and western blots) were examined.RESULTS: Cytokines interleukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) in the COPD and the cold-dryness symptom pattern COPD groups were all significantly higher than in controls(each P < 0.01). IL-6 and IL-8 levels were higher in the cold-dryness symptom pattern COPD group than in the COPD group(each P < 0.05). The AQP5 m RNA expression in the cold-dryness symptom pattern COPD and COPD groups was lower than in the control group(P < 0.01), and that in the cold-dryness symptom pattern COPD group was lower than the COPD group(P < 0.05). The expression of MUC5 AC and MUC5 B m RNAs in the cold-dryness symptom pattern COPD group and COPD group was higher than in the control group(each P < 0.01), and that in the cold-dryness symptom pattern COPD group was higher than the COPD group(P < 0.01, and P < 0.05, respectively).The ratio of MUC5 AC m RNA/MUC5 B m RNA was COPD group < the cold-dryness symptom pattern COPD group < the control group. AQP4 and AQP5 protein expression in the cold-dryness symptom pattern COPD group was lower than that in the COPD group which was lower again than in the control group. MUC5 AC and MUC5 B expression in the cold-dryness symptom pattern COPD group was higher than in the COPD group and higher again than in the control group.CONCLUSION: Cold-dryness affects the expression of mucus-associated protein m RNA and its corresponding proteins, reducing the secretion of aquaporins and increasing the secretion of mucins. Imbalance in aquaporins and mucins can affect the function of mucus, increasing airway obstruction. | Gao Zhen Halmurat Upur Wang Jing Jing Jing Li Zheng Xu Dan Li Fengsen | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 1 |
| 5 | Effect of cold-dryness on pulmonary and immunologic function in chronic obstructive pulmonary disease model rats显示文摘OBJECTIVE: To study the effects of cold-dryness on pulmonary and immunologic function of peripheral T-lymphocytes in chronic obstructive pulmonary disease(COPD) model rats, and to provide references for the prevention and treatment of cold-dryness COPD in the Xinjiang region.METHODS: The COPD model was established with an elastase drip into the trachea combined with smoking. The cold-dryness COPD model was developed by stressing with a cold-dry environment.Success of the model was determined by observation of pathologic lung sections. Rats were sacrificed by exsanguination from the femoral artery and changes of peripheral blood CD4+, CD8+, and CD4+/CD8+were detected by flow cytometry. Data were analyzed with SAS 11.5 statistical software.RESULTS: On the ninetieth day after ending the experiment, Peak expiratory flow in the cold-dryness COPD group was lower than that in the COPD and normal control groups(P<0.01). The time of inspiration in the cold-dryness COPD group was higher than that in the COPD and normal groups(P<0.05).Time of expiration(Te) in the cold-dryness COPD group was higher than that in the COPD and normal groups(P<0.01). 50% tidal volume expiratory flow(EF50) in the cold-dryness COPD group was lower than that in the COPD and normal groups(P<0.01), and EF50 in the COPD group was lower than that in the normal group(P<0.05). CD4+ content of peripheral blood in the cold-dryness COPD group was lower than that in the COPD and the normal groups(P<0.05). CD8+ content in the cold-dryness COPD and COPD groups was higher than that in the normal control group(P<0.01), and CD8+ content in the cold-dryness COPD group was higher than that in the COPD group(P<0.01). CD4+/CD8+in the cold-dryness COPD group and the COPD group was lower than that in the normal control group(P<0.01), and CD4+/CD8+ in the cold-dryness COPD group was lower than that in the COPD group(P<0.05).CONCLUSION: In the cold-dryness COPD model,CD8+ increased and CD4+/CD8+ decreased. Moreover, cold-dryness may aggravate this state. The effects of cold-dryness on pulmonary function mainly manifested as prolongation of Te and decrease of EF50, which could be one of causes of cold-dryness environment in the northwest of China leading to COPD with region characteristics. | Zhen Gao Fengsen Li Halmurat Upur Jiang Min Wang Jing Jing Jing Dan Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 0 |
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