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| 1 | Role of VEGF in the growth and metastasis of a murine bladder carcinoma显示文摘Bladder transitional cell carcinoma is the most common form of carcinoma in the urinary system. Although overexpression of VEGF has been identified in tissue, serum, and urine of patients with bladder cancer, the role of VEGF in transitional cell carcinoma of the bladder has not beenclearly elucidated. Here, we dissected the effect of VEGFduring bladder tumor growth and progression by modifying a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced mouse bladder transitional cell carcinoma cell lineBTT-T739 by stable transfection of antisense VEGF121 cDNA. The transfection resulted in more than 80% reduction inVEGF production. The growth of the transduced tumor cells in vitro was not affected, however, these cells formed small or no tumors in vivo. Even in the tumors formed, there were mini- mal vascularization, extensive necrosis and longerlatency compared to those formed by parental cells. Thepermeability of tumor vasculature and metastatic tumor growth were also significantly suppressed in antisense VEGFcDNA trans- fected cells. In addition, the transfer ofanti-angiogenic gene in a combination of sFlk-1 and ExTekwith electroporation can suppress the tumor growthefficiently. Taken together, these results demonstrated thatVEGF plays an important role in bladder tumorangiogenesis and angiogenesis plays an important role in bladder tumor growth and metastasis. | WANG Feng WU Jihong TIAN Yuhua CHEN Xiafang HU Honghui WU Wensen LI Chuanyuan | 2003 | Chinese Science Bulletin2003，48，22： | 4 |
| 2 | Lipase-catalyzed synthesis of phytostanyl esters in non-aqueous media显示文摘 | Wensen He Chengsheng Jia Yuan Ma Yebo Yang Xiaoming Zhang Biao Feng Lin Yue | 2010 | B, Enzymatic2010，，1： | 1 |
| 3 | Ultra-broadband,fast,and polarization-sensitive photoresponse of low-symmetry 2D NdSb_(2)显示文摘Broadband photodetectors with polarization-sensitive ability have received extraordinary attention for modern optoelectronic devices.Ideal photodetectors should possess high responsivity,fast response,and good stability,which are rare to meet at the same time in one low-symmetric two-dimentional(2D)material.In this work,neodymium diantimonides(RSb_(2)),a member of light rare-earth diantimonides RSb_(2)(R=La–Nd,Sm)with low-symmetry structure,is introduced as a fascinating highly anisotropic 2D material for broadband detection(532 nm to 4μm).The photodetector exhibits a responsivity of 0.49 mA·W^(−1)with 15μs response time at 532 nm and highly stable performance under ambient conditions over 8 months.Furthermore,we identify the polarization-sensitive photoresponse of the detector and demonstrate a high anisotropic factor~1.6.In addition,strong inplane anisotropy is revealed by anisotropic phonon response and the photodetection mechanism is investigated by scanning photocurrent microscopy measurements.This pioneer work on RSb_(2)paves the way for further exploration of 2D RSb_(2)for high performance polarized photodetectors with fast photothermoelectric response. | Gang Li Hanlin Zhang Yong Li Shiqi Yin Xucai Kan Wensen Wei Haifeng Du Binghui Ge Chao An Mingliang Tian Feng Yan Sanjun Yang Tianyou Zhai Liang Li | 2022 | Nano Research2022，15，6： | 1 |
| 4 | Lipase-catalyzed synthesis of phytostanyl esters in non-aqueous media显示文摘 | He Wensen Feng Biao | | 0，，： | 1 |
| 5 | Single-image Super-resolution with Total Generalised Variation and Shearlet Regularisations显示文摘 | FENG Wensen LEI Hong | 2014 | IEEE Transactions on Image Processing2014，8，12： | 1 |
| 6 | INTERFEROGRAM NOISE REDUCTION ALGORITHM BASE ON MAXIMUM A POSTERIORI ESTIMATE显示文摘Interferogram noise reduction is a very important processing step in Interferometric Synthetic Aperture Radar(InSAR) technique. The most difficulty for this step is to remove the noises and preserve the fringes simultaneously. To solve the dilemma, a new interferogram noise reduction algorithm based on the Maximum A Posteriori(MAP) estimate is introduced in this paper. The algorithm is solved under the Total Generalized Variation(TGV) minimization assumption, which exploits the phase characteristics up to the second order differentiation. The ideal noise-free phase consisting of piecewise smooth areas is involved in this assumption, which is coincident with the natural terrain. In order to overcome the phase wraparound effect, complex plane filter is utilized in this algorithm. The simulation and real data experiments show the algorithm can reduce the noises effectively and meanwhile preserve the interferogram fringes very well. | Liu Gang Feng Wensen Chen Runpu Shao Yunfeng | 2014 | Journal of Electronics(China)2014，31，3： | 0 |
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