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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Acute interstitial edematous pancreatitis:Findings on non-enhanced MR imaging显示文摘AIM: To study the appearances of acute interstitial edematous pancreatitis (IEP) on non-enhanced MR imaging. METHODS: A total of 53 patients with IEP diagnosed by clinical features and laboratory findings were underwent MR imaging. MR imaging sequences included fast spoiled gradient echo (FSPGR) fat saturation axial T1-weighted imaging, gradient echo T1-weighted (in phase), single shot fast spin echo (SSFSE) T2-weighted, respiratory triggered (R-T) T2-weighted with fat saturation, and MR cholangiopancreatography. Using the MR severity score index, pancreatitis was graded as mild (0-2 points), moderate (3-6 points) and severe (7-10 points). RESULTS: Among the 53 patients, IEP was graded as mild in 37 patients and as moderate in 16 patients. Forty-seven of 53 (89%) patients had at least one abnormality on MR images. Pancreas was hypointense relative to liver on FSPGR T1-weighted images in 18.9% of patients, and hyperintense in 25% and 30% on SSFSE T2-weighted and R-T T2-weighted images, respectively. The prevalences of the findings of IEP on R-T T2- weighted images were, respectively, 85% for pancreatic fascial plane, 77% for left renal fascial plane, 55% for peripancreatic fat stranding, 42% for right renal fascial plane, 45% for perivascular fluid, 40% for thickened pancreatic lobular septum and 25% for peripancreatic fluid, which were markedly higher than those on in-phase or SSFSE T2-weighted images (P < 0.001).CONCLUSION: IEP primarily manifests on non-enhanced MR images as thickened pancreatic fascial plane, left renal fascial plane, peripancreatic fat stranding, and peripancreatic fluid. R-T T2-weighted imaging is more sensitive than in-phase and SSFSE T2-weighted imaging for depicting IEP. | Xiao-Ming Zhang Zhi-Song Feng Qiong-Hui Zhao Chun-Ming Xiao Donald G Mitchell Jian Shu Nan-Lin Zeng Xiao-Xue Xu Jun-Yang Lei Xiao-Bing Tian | 2006 | World Journal of Gastroenterology2006，12，36： | 9 |
| 3 | CO_2 permeability of fractured coal subject to confining pressures and elevated temperature: Experiments and modeling显示文摘The CO_2 permeability of fractured coal is of great significance to both coalbed gas extraction and CO_2 storage in coal seams, but the effects of high confining pressure, high injection pressure and elevated temperature on the CO_2 permeability of fractured coal with different fracture extents have not been investigated thoroughly. In this paper, the CO_2 permeability of fractured coals sampled from a Pingdingshan coal mine in China and artificially fractured to a certain extent is investigated through undrained triaxial tests. The CO_2 permeability is measured under the confining pressure with a range of 10–25 MPa, injection pressure with a range of 6–12 MPa and elevated temperature with a range of 25–70°C. A mechanistic model is then proposed to characterize the CO_2 permeability of the fractured coals. The effects of thermal expansion, temperature-induced reduction of adsorption capacity, and thermal micro-cracking on the CO_2 permeability are explored. The test results show that the CO_2 permeability of naturally fractured coal saliently increases with increasing injection pressure. The increase of confining pressure reduces the permeability of both naturally fractured coal and secondarily fractured coal. It is also observed that initial fracturing by external loads can enhance the permeability, but further fracturing reduces the permeability. The CO_2 permeability decreases with the elevation of temperature if the temperature is lower than 44°C, but the permeability increases with temperature once the temperature is beyond 44°C. The mechanistic model well describes these compaction mechanisms induced by confining pressure, injection pressure and the complex effects induced by elevated temperature. | JU Yang WANG JianGuo WANG HuiJie ZHENG JiangTao RANJITH Pathegama G GAO Feng | 2016 | Science China(Technological Sciences)2016，59，12： | 8 |
| 4 | Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection显示文摘 | Arie Regev Mariana Berho Lennox J Jeffers Clara Milikowski Enrique G Molina Nikolaos T Pyrsopoulos Zheng-Zhou Feng K.Rajender Reddy Eugene R Schiff | 2002 | The American Journal of Gastroenterology2002，，10： | 7 |
| 5 | Air quality monitoring using mobile microscopy and machine learning显示文摘Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air quality.In fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health Organization.Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning.This platform,termed c-Air,is also integrated with a smartphone application for device control and display of results.This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air.It provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air measurements.Furthermore,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing flights.With its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality. | Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong Steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 6 | 结晶型砷酸镍的溶解性显示文摘结晶型砷酸镍的溶解性用溶液中的Ni和As的浓度来表征.TCLP实验结果表明Ni和As在溶液中的浓度随着实验重复次数的增加而显著降低,说明自制结晶型砷酸镍中含有部分非晶态物质.长期溶解性实验证明结晶型砷酸镍的溶解在15d后达到平衡,并且随着pH值升高溶液中Ni和As浓度降低,在pH9时达到最低的48mg.L-1As和0.2mg.L-1Ni,砷酸镍中的As和Ni在pH3和pH4时按分子式理论值n(Ni)∶n(As)=1.5同步溶解,而由于Ni(OH)2的生成,在高pH值溶液中的n(Ni)∶n(As)远低于理论值1.5.实验结果表明本研究合成的结晶型砷酸镍比Nishi mura等的更稳定,具有更低的溶解性. | 袁铁锤 周科朝 JIA Yong feng G P Demopoulos | 2006 | 化工学报2006，57，1： | 3 |
| 7 | Prediction of centerline cracks incurred in the bloom continuous casting of steel显示文摘An elastic-viscoplastic model is used on the finite element package Abaqus to simulate the thermal and mechanical behavior of bloom casting strand and predict the location and scale of centerline cracks.The formation of centerline cracks can be investigated by the application of this model,which is of benefit to the improvement of processing. | Li Chengbin Brian G THOMAS MEI Feng FAN Zhengjie | 2010 | Baosteel Technical Research2010，4，2： | 3 |
| 8 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 9 | Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts显示文摘Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions(PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs. Confocal laser endomicroscopy is a novel technology that allows for real-time in vivo microscopic imaging with multiple clinical trials identifying characteristic endomicroscopy findings of various pancreatic cystic lesions. DNA-based molecular markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes. | Feng Li Ahmad Malli Zobeida Cruz-Monserrate Darwin L Conwell Somashekar G Krishna | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 2 |
| 10 | Anisotropic damage model under continuum slip crystal plasticity theory for single crystals显示文摘 | Feng L Zhang K S Zhang G Yu H D | 2002 | International Journal of Solids and Structures2002，39，： | 2 |
| 11 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 12 | Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis显示文摘 | Palendira U Kamath A T Feng C G | | Infect Immun0，20，： | 2 |
| 13 | Influence of PbF2 doping on scintillation properties of PbWO4 single crystals显示文摘 | Liu X C Feng X Q Hu G Q | 2002 | Phys Status Solidi (A)2002，190，1： | 2 |
| 14 | Observation of dipole complexes in PbWO4:La3+ single crystals显示文摘 | Han B G Feng X Q | 1998 | J Appl Phys1998，84，5： | 2 |
| 15 | Soil carbon in desertified land in relation to site characteristics显示文摘 | Feng Q Endo K N Cheng G D | 2002 | Geoderma2002，106，： | 2 |
| 16 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 17 | Encapsulation of enzymes in mesoporous host materials via the nonsurfactant- templated sol-gel process 显示文摘 | Wei Y Xu J G Feng Q W | 2000 | Materials Letters2000，44，1： | 1 |
| 18 | Seasonal variation of solvent extractable organic compounds in the aerosols in Qingdao, China显示文摘 | Guo Z G Sheng L F Feng J L | 2003 | Atmospheric Environment2003，37，13： | 1 |
| 19 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 20 | Stability analysis of piecewise discrete-time linear systems显示文摘 | Feng G | 2002 | IEEE Trans on Automatic Control2002，47，7： | 1 |
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