维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

15篇 您的检索式：作者名="Felderbauer"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Pathophysi- ology and treatment of acute pancreatitis: New thera- peutic targets-a ray of hope 显示文摘	Felderbauer P Muller C Bulut K	2005	Basic & Clinical Phar- macology & Toxicology2005，97，：	1
	2	Acquired pure megakaryocytic aplasia: a separate haematological disease entity or a syndrome with multiple causes? 显示文摘	Felderbauer P Ritter PR Mattem D	2004	Eur J Haemato12004，72，6：	1
	3	Solid-pseudopapilary tumor of the pancreas (Frantz tumor) in children:report of four cases and review of the literature显示文摘	Rebhandl W Felderbauer FX Puig S	2001	J Surg Oncol2001，76，4：	1
	4	Sensory neuropeptides and epithelial cell restitution : the relevance of SP-and CGRP-stimulated mast cells显示文摘	Bulut K Felderbauer P Deters S	2008	Int J Colorectal Dis2008，23，5：	1
	5	Vascular endothelial growth factor (VEGF164) ameliorates intestinal epithelial injury in vitro in IEC -18 and Caco -2 monolayers via induction of TGFbeta release from epithelial cells 显示文摘	Bulut K Pennartz C Felderbauer P	2006	Scand Gastroentero2006，41，6：	1
	6	Pancreatitis risk in primary hyperparathyroidism: relation to mutations in the SPINK1 trypsin inhibitor (N34S) and the cystic fi- brosis gene显示文摘	Felderbauer P Karakas E Fendrich V	2008	Am J Gastroenterol2008，103，2：	1
	7	Pathophysiology and treatment of acute pancreatitis:new therapeutic targets-a my of hope显示文摘	Felderbauer P Muller C Bulut K		0，，6：	1
	8	Vascular endothelial growth factor (VEGF<sub>164</sub>) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-&bgr; release from epithelial cells显示文摘	K. Bulut C. Pennartz P. Felderbauer N. Ansorge M. Banasch F. Schmitz W. E. Schmidt P. Hoffmann	2006	Scandinavian Journal of Gastroenterology2006，，6：	1
	9	Solid pseudopapillary tumor of the pancreas in children:report of four cases and reviewof the literature显示文摘	Rebhandl W Felderbauer FX Puig S	2001	J Surg Oncol2001，76，4：	1
	10	Solid-pseudopapillary tumor of the pancreas in children:report of four cases and review of the literature显示文摘	Rebhandl W Felderbauer FX Puig S	2001	J Surg Oncol2001，76，：	1
	11	Pathophysiology and treatment of acute pancreatitis:new therapeutic targets-a ray of hope?显示文摘	Felderbauer P Muller C Bulut K	2005	Basic Clin Pharmacol Toxicol2005，97，：	1
	12	Solid-pseudo papilary tumor of the pancreas (Frantz tumor) in children:report of four cases and review of the literature显示文摘	Rebhandl W Felderbauer FX Puig S	2001	J Surg Oncol2001，76，4：	1
	13	Vascular endothelial growth factor (VEGF164) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-β release from epithelial cells 显示文摘	Bulut K Pennartz C Felderbauer P	2006	Scand J Gastroenterol2006，41，6：	1
	14	Pancreatitis risk in primary hyperparathyroidism:relation to mutations in the SPINK1 trypsin inhibitor( N34S ) and the cystic fibrosis gene 显示文摘	Felderbauer P Karakas E Fendrich V	2008	Am J Gastroentero12008，103，2：	1
	15	钙敏感受体基因突变:慢性胰腺炎新的遗传危险因素显示文摘Objective.In 2003 we identified a family with familial hypocalciuric hypercalcemia(FHH)(heterozygous CASR gene mutation L173P)and a mutation in the pancreatic secretory trypsin inhibitor gene(SPINK1)(N34S).While family members with an isolated calcium-sensing receptor gene(CASR)mutation remained healthy,a combination of the CASR and SPINK1 gene mutation caused chronic pancreatitis(CP).We thus speculate that the combination of two genetic defects affecting calcium homeostasis and pancreatic enzyme activation might represent a novel approach in chronic inherited pancreatic disease.We therefore sought to explore whether CASR gene mutations were prevalent in a cohort of patients with CP and confirmed SPINK1 mutations.Material and methods.A cohort of 19 families(n = 170)with a history of idiopathic CP(ICP)was screened for mutations within the CASR gene;104 members of that cohort had a mutation(N34S)within the SPINK1 gene and 66 of those were suffering from CP.The entire CASR gene was screened for single strand conformation polymorphism under varying polyacrylamide gel conditions and subjected to direct dideoxy nucleotide sequencing of amplified cDNA.Results.Single-strand conformation polymorphisms were observed in 59 samples,clustering of exons 3,4 and 7.DNA sequence analysis revealed a yet unreported missense mutation in exon 7(R896H)and two conservative mutations in exon 4(F391F)and exon 7(E790E).Furthermore,an intronic polymorphism in nucleotide position 493-19 G > A was detected in 19 out of 170 members of that cohort.Conclusions.We identified three novel calcium-sensing receptor gene mutations(1 missense mutation,2 silent mutations and 1 intronic polymorphism)in a cohort of 19 families with ICP.In particular,the kindred with the R896H mutation presenting with a similar pedigree to the family described above may indicate a role for CASR gene mutations in SPINK1-related CP.Again,only the patient with the combination of both CASR and N34S SPINK1 gene mutation developed pancreatitis,whereas in the healthy parents and children only an isolated CASR or N34S SPINK1 gene mutation could be detected.We suggest that the CASR gene is a novel yet undetected co-factor in a multifactorial genetic setting of SPINK1-related pancreatitis that alters the susceptibility for pancreatitis in these patients.	Felderbauer P. Klein W. Bulut K. 张欣	2006	世界核心医学期刊文摘(胃肠病学分册)2006，2，9：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费