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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Control of slime coatings by the use of anionic phosphates : A fundamental study 显示文摘 | Huynh L Feiler A Michelmore A Ralston J Jenkins P | 2000 | Minerals Engineering2000，13，1011： | 1 |
| 3 | Experimental subarachnoid hemorrhage cause early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study显示文摘 | Friedrich B Mtiller F Feiler S | 2012 | J Cereb Blood Flow Metab2012，32，3： | 1 |
| 4 | A two dimensional analytical model for the current distribution in a lateral IGBT 显示文摘 | HENKEL I FEILER W KOSTKA A | 2001 | Solid State Electronies2001，45，10： | 1 |
| 5 | UML&AADL'2007 grand challeoges显示文摘 | Sebastien Gerard Peter Feiler Jean - Francois RoUand | 2007 | ACM2007，4，4： | 1 |
| 6 | Experimental subaraehnoid hemorrhage causes early and longlasting microarterial constriction and microthrombosis: an in -vivo microscopy study 显示文摘 | FRIEDRICH B MULLER F FEILER S | 2012 | J Cereb Blood Flow Metab2012，32，3： | 1 |
| 7 | Idoxuridine-liposome therapy for herpes simplex keratitis 显示文摘 | Smolin G Okumoto M Feiler S | 1981 | Am J Ophthalmol1981，91，2： | 1 |
| 8 | Multistep field plates for high-voltage planar p-n junctions显示文摘 | FEILER W FLACK E GERLACH W | 1992 | IEEE Trans Electron Devices1992，39，6： | 1 |
| 9 | Multistep field plates forhigh-voltage planar p-n junctions显示文摘 | FEILER W FALCK E GERLACH W | 1992 | IEEE Trans Electron Devices1992，39，6： | 1 |
| 10 | AdsoMin (BSM) and bovine serum albumin (BSA) studied with quartz crystal microbalance (QCM-D) 显示文摘 | Feiler A A Sahllhplm A Sandberg T | 2007 | Journal of Colloid and Interface Science2007，315，2： | 1 |
| 11 | Effect of relative humidity on adhesion and frictional properties of microand nano-scopic contacts 显示文摘 | Adam A Feiler Pal Jenkins Mark W Rutland | 2005 | Joumal of Adhesion Science and Technology2005，19，： | 1 |
| 12 | Adsorption and viscoelastic properties of fractionated mucin (BSM) and bovine serum albumin (BSA) studied with quartz crystal microbalance (QCM-D) 显示文摘 | Feiler A A Sahlholm A Sandberg T Caldwell K D | 2007 | Journal of Colloid and Interface Science2007，315，2： | 1 |
| 13 | The Architecture Analysis&Design Language(AADL):An Introduction显示文摘 | Feiler P Gluch D Hudak J | 2006 | The Architecture Analysis&Design Language(AADL):An Introduction-research Gate2006，2，2： | 1 |
| 14 | The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells显示文摘 | Feiler HS Desprez T Santoni V | 1995 | EMBO J1995，14，22： | 1 |
| 15 | Small-signal and high frequency noise modeling of SiGe HBTs显示文摘 | Basaran U Wieser N Feiler G | 2005 | IEEE Tras Microwave Theory Tech2005，53，3： | 1 |
| 16 | Small-signal and high frequency noise modeling of SiGe HBTs显示文摘 | Basaran U Wieser N Feiler G | 2005 | IEEE Trans Mcrow Theory Tech2005，53，3： | 1 |
| 17 | Association of the telomere-telomere-binding protein complex of hypotrichous ciliates with the nuclear matrix and dissociation during replication显示文摘 | Postberg J Juranek SA Feiler S | 2001 | J Cell Sci2001，114，10： | 1 |
| 18 | Multistep Field Plates for High-voltage Planar p-n Junctions显示文摘 | Feiler W Falck E Gerlach W | 1992 | IEEE Transactions on Electron Devices1992，39，6： | 1 |
| 19 | Contributionofmatrixmetalloproteinase9tocerebraledemaandfunctionaloutcomefollowingexperimentalsubarachnoidhemorrhage显示文摘 | FeilerS PlesnilaN ThaiSC etal | 2011 | CerebrovascDis2011，32，3： | 1 |
| 20 | Case study, dynamic capabilities and upstream strategy: Supermajor EXP 显示文摘 | Feiler P Teece D | 2014 | Energy Strategy Reviews2014，，3： | 1 |
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