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| 1 | Intestinal microbiota in inflammatory bowel disease:Friend of foe?显示文摘Inflammatory bowel disease(IBD) arises from disruption of immune tolerance to the gut commensal microbiota,leading to chronic intestinal inflammation and mucosal damage in genetically predisposed hosts.In healthy individuals the intestinal microbiota have a symbiotic relationship with the host organism and possess important and unique functions,including a metabolic function(i.e.digestion of dietary compounds and xenobiotics,fermentation of undigestible carbohydrates with production of short chain fatty acids),a mucosal barrier function(i.e.by inhibiting pathogen invasion and strengthening epithelial barrier integrity),and an immune modulatory function(i.e.mucosal immune system priming and maintenance of intestinal epithelium homeostasis).A fine balance regulates the mechanism that allows coexistence of mammals with their commensal bacteria.In IBD this mechanism of immune tolerance is impaired because of several potential causative factors.The gut microbiota composition and activity of IBD patients are abnormal,with a decreased prevalence of dominant members of the human commensal microbiota(i.e.Clostridium Ⅸa and Ⅳ groups,Bacteroides,bifidobacteria) and a concomitant increase in detrimental bacteria(i.e.sulphate-reducing bacteria,Escherichia coli).The observed dysbiosis is concomitant with defective innate immunity and bacterial killing(i.e.reduced mucosal defensins and IgA,malfunctioning phagocytosis) and overaggressive adaptive immune response(due to ineffective regulatory T cells and antigen presenting cells),which are considered the basis of IBD pathogenesis.However,we still do not know how the interplay between these parameters causes the disease.Studies looking at gut microbial composition,epithelial integrity and mucosal immune markers in genotyped IBD populations are therefore warranted to shed light on this obscure pathogenesis. | Francesca Fava Silvio Danese | 2011 | World Journal of Gastroenterology2011，17，5： | 30 |
| 2 | Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis显示文摘Cholangiocytes,上皮细胞衬里胆管,是在几肝疾病的靶细胞。自从开始, Cholangiopathies 和 cholangiocarcinoma 在许多科学家产生兴趣。发展中的机制,和这些疾病的治疗学的工具仍然是未定义的。几研究证明许多荷尔蒙, neuropeptides 和 neurotransmitters 在长期的胆汁的疾病期间调整恶意、非恶意的 cholangiocyte 病理生理学。这评论的目的是介绍在贡献了澄清与胆汁郁积和 cholangiocarcinoma 开发联系的 pathophysiologic 事件的紧张、神经内分泌的规定的角色的最近的年里出版的几研究的调查结果。这张手稿被组织成二部分。第一部分提供肝的神经分布和影响 cholangiocyte 功能和新陈代谢的神经内分泌荷尔蒙, neurotransmitters 和 neuropeptides 的起源的概述。第一节也考察几神经内分泌荷尔蒙和神经系统在胆汁郁积期间在 cholangiocyte 生长,幸存和机能活动上玩的效果。在第二节,我们总结在恶意的 cholangiocyte 生长的规定描述神经系统和神经内分泌荷尔蒙的角色的一些研究的结果。 | Marco Marzioni Giammarco Fava Antonio Benedetti | 2006 | World Journal of Gastroenterology2006，12，22： | 8 |
| 3 | Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome显示文摘In acute promyelocytic leukemia, differentiation thera-py based on all-trans-retinoic acid can be complicated by the development of a differentiation syndrome(DS). DS is a life-threatening complication, characterized by respiratory distress, unexplained fever, weight gain, interstitial lung infiltrates, pleural or pericardial effusions, hypotension and acute renal failure. The diagnosis of DS is made on clinical grounds and has proven to be difficult, because none of the symptoms is pathognomonic for the syndrome without any definitive diagnostic criteria. As DS can have subtle signs and symptoms at presentation but progress rapidly, end-stage DS clinical picture resembles the acute respiratory distress syndrome with extremely poor prognosis; so it is of absolute importance to be conscious of these complications and initiate therapy as soon as it was suspected. The radiologic appearance resembles the typical features of cardiogenic pulmonary edema. Diagnosis of DS remains a great skill for radiologists and haematologist but it is of an utmost importance the cooperation in suspect DS, detect the early signs of DS, examine the patients' behaviour and rapidly detect the complications. | Luciano Cardinale Francesco Asteggiano Federica Moretti Federico Torre Stefano Ulisciani Carmen Fava Giovanna Rege-Cambrin | 2014 | World Journal of Radiology2014，6，8： | 6 |
| 4 | Heterogeneity of the intrahepatic biliary epithelium显示文摘这评论的目的是在 apoptotic,增生的和分泌活动与变化构画出与胆汁的上皮的词法异质和对肝胃肠激素和肽和肝损伤的不同大小的胆汁管的异构的 pathophysiological 回答有关的最近的调查结果。因为胆汁的上皮细胞(cholangiocytes ) 是人的 cholangiopathies 的目标的识别,胆汁的功能的知识很快正在增加,它被胆汁管的增长 / 损坏在尺寸的一个小范围以内描绘。胆汁的上皮的唯一的解剖,形态学,神经分布和血管形成与在胆汁的树的不同区域以内的 cholangiocytes 的功能一致。在活体内模型[例如,胆汁管结扎( BDL ),部分肝切除术,胆汁酸,四氯化碳( CCl4 )或 alpha-naphthylisothiocyanate ( ANIT )喂]并且在活体内试验性的工具[例如,刚孤立小、大的 cholangiocytes 或肝内胆汁管单位( IBDU )和小、大的鼠科的 cholangiocytes 的主要文化]允许我们表明肝内的胆汁的上皮的词法、功能的异质。这些模型表明了微分分泌活动和异构的 apoptotic 和不同的大小的管的增生的回答。类似于限制为特定的大小的管的 cholangiocyte 增长 / 损害的动物模型,在人的肝疾病,胆汁管损坏支配特定的大小的胆汁管。与肝内的胆汁的上皮的功能的异质有关的未来研究可以与 cholangiopathies 为病人揭示新 pathophysiological 治疗。 | Shannon Glaser Heather Francis Sharon DeMorrow Gene LeSage Giammarco Fava Marco Marzioni Julie Venter Gianfranco Alpini | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 5 | Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome显示文摘 | Giovanni Volpicelli Alessandro Mussa Giorgio Garofalo Luciano Cardinale Giovanna Casoli Fabio Perotto Cesare Fava Mauro Frascisco | 2006 | American Journal of Emergency Medicine2006，，6： | 3 |
| 6 | Cyclodextrin effects on the ex-situ bioremediation of a chronically polychlorobiphenyl-contaminated soil显示文摘 | Fava F Di Gioia D Marchetti L | 1998 | Biotechnology and Bioengineering1998，58，4： | 2 |
| 7 | Calculation and simulation of impedance diagrams of planar rectangular spiral coils for eddy current testing显示文摘 | Javier O. Fava Marta C. Ruch | 2005 | NDT and E International2005，，5： | 2 |
| 8 | Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis显示文摘 | Kittichai Promrat David E. Kleiner Heather M. Niemeier Elizabeth Jackvony Marie Kearns Jack R. Wands Joseph L. Fava Rena R. Wing | 2009 | Hepatology2009，，1： | 2 |
| 9 | LPS/TLR4 signal transduction pathway显示文摘 | Durie F H Fava R A Noelle R J | 2008 | Cytokine2008，42，2： | 1 |
| 10 | MLeukocytes and the risk of ischemic diseases显示文摘 | Fava M | 1987 | JAMA1987，257，17： | 1 |
| 11 | High-dose immunoglobulines and extracorporeal photoehemotherapy in the treatment of febrile ulcerone- erotic Mucha-Ilabermaml disease 显示文摘 | Marenco F Fava P Fierro MT | 2010 | Dermatol Ther2010，23，4： | 1 |
| 12 | Mechananical fregmentation and pharmacologic thrombolysis in massive pulmonary embolism显示文摘 | Fava M Logola S Flore S | 1997 | J Vasa Inter Radio1997，8，26： | 1 |
| 13 | Intermittent maximal androgen blockade in patients with metastatic peostate cancer:an EORTC feasibility study显示文摘 | Albrecht W Collette L Fava C | 2003 | Eur Urol2003，44，： | 1 |
| 14 | Diabetic endothelial dysfunction:effect of free radical scavenging in Type 2 diabetic patients显示文摘 | De Mattia G Laurenti O Fava D | 2003 | J Diabetes Complications2003，，： | 1 |
| 15 | Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced dia- betes in mice through a mechanism associated with endotoxaemia 显示文摘 | Cani P D Neyrinck A M Fava F | 2007 | Diabetologia2007，50，11： | 1 |
| 16 | Major Depressive Disorder 显示文摘 | Fava M Kendler KS | 2000 | Neuron2000，28，2： | 1 |
| 17 | Meiotic spindle imaging in hu- man oocytes frozen with a slow freezing procedure involving high su- crose concentration显示文摘 | Bianchi V Coticchio G Fava L | 2005 | Hum Reprod2005，20，4： | 1 |
| 18 | Usefulness of quantitative assessment of the WT I gene transcript as a marker for minimal residual disease detection 显示文摘 | Cilloni D Gottardi E Fava M | 2003 | Blood2003，102，77： | 1 |
| 19 | Phosphate removal in anaerobic liquors by struvite crystallization without addition of chemical:preliminary results显示文摘 | Battistoni P Fava G Pavan P | 1997 | Water Research1997，31，11： | 1 |
| 20 | Intraoperative subcortical language tract mapping guides surgical removal of gliomas involving speech areas显示文摘 | Bello L Gallucci M Fava M | 2007 | Neurosurgery2007，60，1： | 1 |
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