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| 1 | 高盐饮食通过促进蛋白tau磷酸化损伤大脑认知功能显示文摘来自美国威尔康乃尔医学院的研究人员在一项新的针对小鼠的研究发现,高盐饮食可能会导致化合物一氧化氮的缺乏,从而对认知功能产生负面影响;当一氧化氮水平过低时,大脑中蛋白tau发生磷酸化,从而导致痴呆症。该论文最近在线发表在Nature上。在这项新的研究中,研究人员试图了解食盐摄入与较差认知功能间的关系,发现血管中一氧化氮产生的减少可通过抑制一系列导致蛋白tau病变的酶的活性而影响神经元中tau蛋白的稳定性,而蛋白tau为神经元的支架(细胞骨架)提供结构,一旦蛋白tau脱离细胞骨架则会在大脑中积聚并引起认知问题。因此这些研究人员得出结论:降低食盐摄入量并维持大脑中的健康血管可能“避免”痴呆症。 | FARACO G HOCHRAINER K SEGARRA S G 本刊编辑部 | 2019 | 实用心脑肺血管病杂志2019，27，10： | 8 |
| 2 | The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (Orexin) receptor 2 gene显示文摘 | Faraco J Li R | 1999 | Cell1999，98，3： | 1 |
| 3 | Laccases: a never-ending story 显示文摘 | Paola Giardina Vincenza Faraco Cinzia Pezzella | 2010 | Cellular and Molecular Life Sciences2010，67，3： | 1 |
| 4 | Impaction of mandibular molar by supernumerary tooth: case report 显示文摘 | Rosa FM Stankiewicz A Faraco IM Jr | 2008 | J Dent Child (Chic)2008，75，2： | 1 |
| 5 | Narcolepsy is strongly associated with the T-cell receptor alpha locus显示文摘 | Hallmayer J Faraco J Lin L | | 0，，06： | 1 |
| 6 | Narcolepsy with hypocretin/orexin deficiency,infections and autoimmunity of the brain显示文摘 | Kornum BR Faraco J Mignot E | 2011 | Curr Opin Neurobiol2011，21，6： | 1 |
| 7 | Narcolepsy is strongly associated with the T-cell receptor alpha locus 显示文摘 | Hallmayer J Faraco J Lin L | 2009 | Nat Genet2009，41，6： | 1 |
| 8 | Immuno Chip study implicates antigen presentation to T cells in narcolepsy显示文摘 | Faraco J Lin L Kornum BR | 2013 | PLo S Genet2013，9，10： | 1 |
| 9 | Metal-activated laccase promoters显示文摘 | FARACO V GIARDINA P PALMIERI G | 2002 | Prog Biotechnol2002，21，2： | 1 |
| 10 | Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain 显示文摘 | FARACO G PANCANI T FORMENTINI L | 2006 | Mol Pharmacol2006，70，6： | 1 |
| 11 | The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin(orexin)receptor 2 gene显示文摘 | Lin L Faraco J Li R | 1999 | Cell1999，98，3： | 1 |
| 12 | Laccases:a never- ending story显示文摘 | Giardina P Faraco V Pezzella C | 2010 | Cellular and Molecular Life Sciences2010，67，3： | 1 |
| 13 | Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement 显示文摘 | Faraco IM Jr | 2001 | Dent Traumatol2001，17，4： | 1 |
| 14 | Using Lab VIEW for applying mathematical models in representing phenomena显示文摘 | Faraco G Gabriele L | 2007 | Computers & Education2007，49，： | 1 |
| 15 | Narcolepsy with hypocretin/orexin deficiency,infections and autoimmunity of the brain显示文摘 | Kornum BR Faraco J Mignot E | | 0，，06： | 1 |
| 16 | Regulation of hypocretin(OREXIN) expression in embryonic zebrafish显示文摘 | Faraco J H Appelbaum L Matin W | | 0，，： | 1 |
| 17 | Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants显示文摘 | Yokogawa T Matin W Faraco J | | 0，，10： | 1 |
| 18 | Pharmacological inhibition of histone deacetylases by suberoylanilide hydrox- amic acid specifically alters gene expression and reduces is- chemic injury in the mouse brain 显示文摘 | Faraco G Paneani T Formentini L | 2006 | Mol Pharmacol2006，70，6： | 1 |
| 19 | Characterization of laccase isoforms produced by Pleurotus ostreatus in solid state fermentation of sugarcane bagasse显示文摘 | KARP S G FARACO V AMORE A | 2012 | Bioresouree Teehnol2012，114，2： | 1 |
| 20 | The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene显示文摘 | Lin L Faraco J Li R | 1999 | Cell1999，98，： | 1 |
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