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| 1 | Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury显示文摘Background:Recent studies suggest that acute kidney injury(AKI)can be treated with renal replacement therapy(RRT).However,its benefits to patients with sepsis-associated AKI(SA-AKI),which is linked to high mortality and morbidity rates,remain under debate.The aim of this study was to compare the outcomes of different RRT strategies for patients with SA-AKI.Methods:This retrospective study evaluated patients who were admitted to the hospital with sepsis and devel-oped SA-AKI during hospitalization from 1st January 2014 to 31st January 2019.Mortality,renal recovery,and systemic organ function at 90 days following admission were compared between the RRT group(RG)and non-RRT group(NRG),as well as the early-RRT group(EG)and delayed-RRT group(DG).The groups were defined according to the time from admission to RRT initiation(criterion 1,EG1 and DG1)and Kidney Disease Improving Global Outcomes(KDIGO)classification(criterion 2,EG2 and DG2).Categorical and continuous variables were compared using the chi-squared test or Fisher’s exact test and Student’s t-test or Wilcoxon test.Kaplan-Meier curves were constructed to determine the unadjusted survival rates for the different subgroups.Results:A total of 116 patients were included in this study;of those,38 received RRT and 46 expired within 90 days.Among different strategies of RRT,there were no significant differences found in 90-day mortality(RG vs.NRG:��2=0.610,P=0.435;EG1 vs.DG1:��2=0.835,P=0.360;EG2 vs.DG2:��2=0.022,P=0.899)and renal recovery.However,the values of change in sequential organ failure assessment(ΔSOFA)max-min of patients in the EG and RG were significantly higher than those recorded in the NRG(ΔSOFA RG=7.0,ΔSOFA NRG=3.60,ΔSOFA EG1=9.00,ΔSOFA EG2=6.30;P<0.050).Also,the 90-day renal recovery in the EG was better than that noted in the DG with criterion 1(87.5%vs.38.5%,respectively,��2=10.425,P=0.032),suggesting that RRT(especially timely RRT)may be beneficial to the restoration of systemic organ function in patients with SA-AKI.Conclusion:RRT did not reduce the 90-day mortality among patients with SA-AKI.However,timely RRT may benefit the restoration of systemic organ function,thereby improving the quality of life of patients. | Yiwen Fan Liang Chen Shaowei Jiang Yingying Huang Yuxin Leng Chengjin Gao | 2022 | Journal of Intensive Medicine2022，2，3： | 2 |
| 2 | The Fracture of Concrete Based on Acoustic Emission显示文摘 | HU Shaowei LU Jun FAN Xiangqian | 2011 | Advanced Materials Research2011，8081，： | 1 |
| 3 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 4 | The fracture of concrete based on acoustic emission 显示文摘 | Hu Shaowei Lu Jun Fan Xiangqian | 2011 | Advanced Materials Research2011，8081，： | 1 |
| 5 | Concrete damage constitutive relation based on characteristic parameters of acoustic emission显示文摘 | HU Shaowei LU Jun FAN Xiangqian | 2012 | Applied Me- chanics and Materials2012，，157158： | 1 |
| 6 | DSP & FPGA-based control architecture for a highly integrated robot hand with enhanced impedance performance显示文摘 | 吴克 Lan Tian Chen Yangbin Liu Yiwei Jin Minghe Fan Shaowei Chen Zhaopeng Liu Hong | 2010 | High Technology Letters2010，16，2： | 1 |
| 7 | Enhancement of stability and activity of Cu/ZnO/A1203 catalysts by microwave irradi- ation for liquid phase methanol synthesis 显示文摘 | Li Zhong Yan Shaowei Fan Hui | 2013 | Fuel2013，106，： | 1 |
| 8 | Influence of Crack Ini- tiation Length upon Fracture Parameter of High Strength Reinforced Concrete 显示文摘 | Fan Xiangqian Hu Shaowei | 2013 | Applied Clay Science2013，79，6： | 1 |
| 9 | Hybrid Mapping Method:from Human to Robotic Hands with Dissimilar Kinematics显示文摘Mapping grasps from human to anthropomorphic robotic hands is an open issue in research,because the master hand and the slave hand have dissimilar kinematics.This paper proposes a hybrid mapping method to solve this problem.In the proposed method,fingers in the master and the slave hands are divided into vital and synergic fingers according to their contribution to the grasping task.The tip of the vital finger of the master hand is first mapped to that of the slave hand while ensuring that both are in simultaneous contact with the object to be grasped.Following postural synergy theory,joints of the other synergic fingers of the slave hand are then used to generate an anthropomorphic grasping configuration according to the shape of the object to be grasped.Following this,a human-guided impedance controller is used to reduce the pre-grasping error and realize compliant interaction with the environment.The proposed hybrid mapping method can not only generate the posture of the humanoid envelope but can also carry out impedance-adaptive matching.It was evaluated using simulations and an experiment involving an anthropomorphic robotic slave hand. | Bingchen Liu Li Jiang Shaowei Fan | 2022 | Journal of Bionic Engineering2022，19，4： | 0 |
| 10 | Bio-inspired design of alternate rigid-flexible segments to improve the stiffness of a continuum manipulator显示文摘Intrinsic flexible structures enable a continuum manipulator to exhibit attractive dexterity and intrinsic compliance over traditional hyper-redundant robots.However,its insufficient stiffness makes the performance of continuum manipulators unsatisfactory and thus limits the applications in many fields.A significant challenge is how to make a trade-off among dexterity,compliance and stiffness.From an evolutionary perspective,this paper compares several biological structures that enable the continuum manipulator function,and intends to reveal the mechanism on how the biological structures can improve the stiffness.The notochord and the vertebral column with acoelous centra are abstracted and physically implemented.A fundamental roddriven continuum manipulator is also introduced as a comparison.The stiffness models of these three continuum manipulators are proposed,and comparative experiments are conducted to verify their stiffness properties.Our results demonstrate that the rigid-flexible segmental structure can improve the stiffness properties of a continuum manipulator. | LIU Hong WANG HaiRong FAN ShaoWei YANG DaPeng | 2020 | Science China(Technological Sciences)2020，63，8： | 0 |
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