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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers 显示文摘 | Harris M P Fallon J F Prum R O | 2002 | J Exp Zool2002，，294： | 1 |
| 3 | A review of theempirical ethical decision-making literature:1996-2003显示文摘 | FALLON M J BUTTERFIELD K D | 2005 | Journal of Business Ethics2005，59，4： | 1 |
| 4 | The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses显示文摘 | Abbott M Wells D Fallon J | 1999 | J Neurosci1999，19，： | 1 |
| 5 | Population-based study of survival after osteoporotic fractures显示文摘 | Cooper C Atkinson E J O'Fallon W M | 1993 | Am J Epidemiol1993，137，： | 1 |
| 6 | Cooperative AUV navigation using a single maneuvering sur- face craft 显示文摘 | FALLON M F PAPADOPOULOS G LEONARD J J | 2010 | The International Journal of Robotics Re- search2010，29，12： | 1 |
| 7 | preimplantation genetic diagnosis for spinal muscular atrophy type I 显示文摘 | Fallon L Harton GL Sisson ME Rodriguez E Field LK Fugger EF Geltinger M Sun Y Dorfmann A Schoener C Bick Dm Schulman J Levinson G Black SH | 1999 | Neurology1999，53，： | 1 |
| 8 | Pulmonary dysfunction in chronic liver disease显示文摘 | Fallon M Abrams C X | 2000 | Hepatology2000，32，： | 1 |
| 9 | Rituximab in combination with CHOP or fludarabine in low-grade lymphoma 显示文摘 | Czuczman M S Fallon A Mohr A | 2002 | Semin Oncol2002，29，2： | 1 |
| 10 | Mouse model of femoral artery denudation injury associated with the rapid accumulation of adhesion molecules on the luminal surface and recruitment of neutrophils显示文摘 | Roque M Fallon JT Badimon JJ | 2000 | Arterioscler Thromb Vasc Biol2000，20，2： | 1 |
| 11 | In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines 显示文摘 | Heffernan M J Zaharoff DA Fallon JK | 2011 | Biomaterials2011，32，3： | 1 |
| 12 | Synchronization of Aedes albopictus mosquito cells using hydroxyurea显示文摘 | G-enday A Blauwkamp T S Fallon A M | 1997 | Insect Molecular Biology1997，6，2： | 1 |
| 13 | Chemical shift MRI of the femoral head:an in vitro study of normal hips and hips with avascular necrosis显示文摘 | Mitchell DG Joseph PM Fallon M | 1987 | AJR1987，148，： | 1 |
| 14 | ABC of paliative care:Principles of palliative care and pain control显示文摘 | Biu O'Neill Fallon M | 1997 | BMJ1997，315，9： | 1 |
| 15 | In vivo induction of massive proliferation,directed migration,and differentiation of neural cells in the adult mammalian brain显示文摘 | Fallon J Reid S Kinyamu R Opole I Opole R Baratta J Korc M Endo TL Duong A Nguyen G Karkehabadhi M Twardzik D Patel S Loughlin S | | 0，，： | 1 |
| 16 | Determination of Therapeutic and Growth Promoting Use of Clenbuterol by Plasma Analysis显示文摘 | Blass A Dave M Fallon R J | 1999 | J Vet Pharmacol Ther1999，22，： | 1 |
| 17 | Drug-resistant schistosmiasis: resistance to praziquantel and oxamniquine include in schistosoma mansoni in mice is drug specific显示文摘 | Fallon PG Doenhoff M / | 1994 | Am J Trop Med Hyg1994，51，1： | 1 |
| 18 | Methylene blue and cirrhosis:pathophysiologic insights,therapeutic dilemmas 显示文摘 | Michael B Fallon M D | 2000 | Ann Inter Med2000，133，9： | 1 |
| 19 | Cooperation between VEGF and TNF-alpha is necessary for exposure of active tissue factor on the surface of human endothelial cells 显示文摘 | Camera M Giesen PL Fallon J | 1999 | Arterioscler Thromb Vasc Biol1999，19，3： | 1 |
| 20 | Value-based reliability transmission planning显示文摘 | DALTON J G GARRISON D L FALLON C M | 1996 | IEEE Transactions on Power System1996，11，3： | 1 |
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