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| 1 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | 糖尿病患者累积收缩压负荷与心血管病风险的关系显示文摘该研究旨在评估2型糖尿病患者累积收缩压负荷与心血管事件风险的关系。方法:对百普乐和达美康缓释片对糖尿病和血管疾病的对照评估试验的观察性研究(action in diabetes and vascular disease preterax and diamicron MR controlled evaluation post trial observational study, ADVANCE-ON)中的2型糖尿病患者进行事后分析。 | Wang N Harris K Hamet P Harrap S Mancia G Poulter N Williams B Zoungas S Woodward M Chalmers J Rodgers A 刘青(译) 郑武洪(审校) | 2022 | 中华高血压杂志2022，30，12： | 2 |
| 4 | The high-molecular-weight subunits of glutenin:structure,genetics and relationship to bread-making quality显示文摘 | Payne P I Harris P A Law C N Holt L M Blackman J A | 1980 | Ann Technol Agric1980，29，2： | 2 |
| 5 | The value relevance of German accounting measures:An empirical analysis显示文摘 | Harris M S Moller H P | 1994 | Journal of Accounting Research1994，32，： | 1 |
| 6 | Thining and opening of carbon nanotubes by oxidation using carbon dioxide 显示文摘 | Tsang S C Harris P J F Green M L H | 1993 | Nature1993，362，： | 1 |
| 7 | Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers 显示文摘 | Harris M P Fallon J F Prum R O | 2002 | J Exp Zool2002，，294： | 1 |
| 8 | Change in eco system service values in the San Antonio area, Texas显示文摘 | Kreuter U P Harris H G Matlock M D | 2001 | Eco- logical Economics2001，39，3： | 1 |
| 9 | Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase Ⅱ显示文摘 | Tulsiani D R P Harris T M Touster O | 1982 | Journal of Biological Chemistry1982，257，14： | 1 |
| 10 | Identity consequences of attachment to mothers and fathers among late adolescents显示文摘 | Benson M J Harris P B Rogers C S | | 0，，02： | 1 |
| 11 | Triple negative breast cancer: current understanding of biology and treatment options 显示文摘 | KANG S P MARTEL M HARRIS L N | 2008 | Curt Opin Obstet Gynecol2008，20，1： | 1 |
| 12 | Establishment of conditions for the detection of bovine herpesvirus-1 by polymerase chain reaction using primers in the thymidine kinase region显示文摘 | Yason C V Harris L M McKenna P K | 1995 | Can J Vet Res1995，59，2： | 1 |
| 13 | Phosphate-induced metal immobilization in a contaminated site 显示文摘 | CAO R X MA L Q CHEN M SINGH S P HARRIS W G | 2003 | Environmental Pollution2003，122，： | 1 |
| 14 | Apparent digestibility of rendered animal protein ingredients for rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | BUREAU D P HARRIS A M CHO C Y | 1999 | Aquaculture1999，180，34： | 1 |
| 15 | The relationship between optical inhomogeneity and film strueture显示文摘 | HARRIS M MACLEOD H A OGURE E P | 1979 | Thin Solid Films1979，57，1： | 1 |
| 16 | Utilization of black locust (Robinia pseudoacacia) leaf meal by rabbits显示文摘 | Cheeke P R Harris D J Patton N M | 1984 | Nitrogen Fixing Tree Research Reports1984，，2： | 1 |
| 17 | Unconformities and porosity in carbonate strata 显示文摘 | Budd D A Saller A H Harris P M | 1995 | AAPG Memoir 631995，，： | 1 |
| 18 | Transforaminal lum- bar interbody fusion:the effect of various instrumentation tech- niques on the flexibility of the lumbar spine显示文摘 | Harris B M Hilibrand A S Savas P E | 2004 | Spine2004，29，4： | 1 |
| 19 | Human gait recogni tion in canonical space using temporal templates 显示文摘 | HUANG P HARRIS C NIXON M | 1999 | Vision Image and Signal Processing1999，146，2： | 1 |
| 20 | Direct in- fusion of a variant of insulin - like growth factor - I into the skin of sheep and effects on local blood flow, amino acid utilization and cell reolication显示文摘 | HARRIS P M MCBRIDE B W GURNSEY M P | 1993 | J Endocrinol1993，139，3： | 1 |
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