|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 2 | Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients显示文摘AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2017 for histologically-proven AIH were retrospectively analyzed. However, 52 patients(9.2%) fulfilled the criteria for ALF defined by the 'American Association for the Study of the Liver(AASLD)'. According to this definition, patients with 'acute-on-chronic' or 'acute-on-cirrhosis' liver failure were excluded. Following parameters with focus on potential triggering factors were evaluated: Patients' demographics, causation of liver failure, laboratory data(liver enzymes, MELD-score, autoimmune markers, virus serology), liver histology, immunosuppressive regime, and finally, outcome of our patients.RESULTS The majority of patients with ALF were female(84.6%) and mean age was 43.6 ± 14.9 years. Interestingly, none of the patients with ALF was positive for antiliver kidney microsomal antibody(LKM). We could identify potential triggering factors in 26/52(50.0%) of previously healthy patients presenting ALF as their first manifestation of AIH. These were drug-induced ALF(57.7%), virus-induced ALF(30.8%), and preceding surgery in general anesthesia(11.5%), respectively. Unfortunately, 6 out of 52 patients(11.5%) did not survive ALF and 3 patients(5.7%) underwent liver transplantation(LT). Comparing data of survivors and patients with non-recovery following treatment, MELDscore(P < 0.001), age(P < 0.05), creatinine(P < 0.01), and finally, ALT-values(P < 0.05) reached statistical significance. CONCLUSION Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome. | Matthias Buechter Paul Manka Falko Markus Heinemann Monika Lindemann Hideo Andreas Baba Martin Schlattjan Ali Canbay Guido Gerken Alisan Kahraman | 2018 | World Journal of Gastroenterology2018，24，13： | 8 |
| 3 | 丛枝菌根菌剂对大田棉花抗病性及产量的影响显示文摘在大田棉花上接种两种丛枝菌根真菌(Glomus mosseae和Glomus etunicatum)。两种处理的发病率和病情指数比对照都有显著下降,其中最低的处理(G.etunicatum)分别降低了47.8%和56.6%。两种处理的皮棉产量比对照都有显著增加,分别增产了48.0%和13.6%。两种处理的丛枝菌根侵染情况表现出与产量的正相关关系。 | 龙宣杞 王继辉 陈金梅 崔卫东 哈布力汗 杨蓉 陆军 Falko Feldmman | 2007 | 新疆农业科学2007，44，4： | 5 |
| 4 | 接种丛枝菌根菌对盆栽孔雀草生长的影响显示文摘在盆栽孔雀草上接种两种丛枝菌根真菌(Glomus mosseae和Glomus versiforme)。在两个月的试验期内,前40 d两种处理在株高、茎粗、主叶片数上都表现出显著的促进宿主植物营养生长的作用,在单株花蕾数上表现出延缓生殖生长的作用;后20 d两种处理在茎粗方面以及处理G.versiforme在株高上仍然表现出显著的促进宿主植物营养生长的作用,而两种处理在单株花蕾数上表现出促进生殖生长的作用,但对花冠直径没有影响。 | 马剑 龙宣杞 杨蓉 徐斌 李建军 詹发强 Falko Feldmman | 2007 | 新疆农业科学2007，44，4： | 4 |
| 5 | 超细聚酰胺/弹性纤维混纺产品的染色固色处理显示文摘聚酰胺纤维/氨纶弹性纤维(PA/EL)混纺产品染色后湿牢度通常不及纯聚酰胺纤维,尤其是聚酰胺超细纤维,湿牢度更差。在染色后处理工艺中,使用司马(ZSM)公司的后处理助剂ZETESAL NR Gold和ZETESAL NR Gold(液体),可满足高牢度、低黄变的要求。此外,其优异的耐酸稳定性可赋予工艺更高的可靠性。 | Claudia Hemeltjen Falko Richter Andreaa Schonfeld Klaus Wolf | 2008 | 印染2008，34，2： | 4 |
| 6 | Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells显示文摘AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(PSCs).METHODS Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated PSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. Real-time PCR was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 F-proline.RESULTS Sustained culture of originally quiescent PSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to PSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; P < 0.05) and increased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; P < 0.05). No such effects were observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured PSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; P < 0.05). There was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated PSCs.CONCLUSION The three D-vitamins inhibit, with similar efficiencies, activation of PSCs in vitro, but cannot reverse the phenotype once the cells are fully activated. | Peter Wallbaum Sarah Rohde Luise Ehlers Falko Lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd Joachim Krause Robert Jaster | 2018 | World Journal of Gastroenterology2018，24，2： | 3 |
| 7 | Distinct antifibrogenic effects of erlotinib,sunitinib and sorafenib on rat pancreatic stellate cells显示文摘AIM:To study if three clinically available small molecule kinase inhibitors(SMI),erlotinib,sunitinib and sorafenib,exert antifibrogenic effects on pancreatic stellate cells(PSC)and analyze the basis of their action.METHODS:Cultured rat PSC were exposed to SMI.Cell proliferation and viability were assessed employing 5-bromo-2’-deoxyuridine incorporation assay and flow cytometry,respectively.2-Deoxy-2-[18F]fluoroglucose(18F-FDG)uptake was measured to study metabolic activity.Exhibition of the myofibroblastic PSC phenotype was monitored by immunofluorescence analysis ofα-smooth muscle actin(α-SMA)expression.Levels of mRNA were determined by real-time PCR,while protein expression and phosphorylation were analyzed by immunoblotting.Transforming growth factor-β1 (TGF-β1)levels in culture supernatants were quantified by ELISA.RESULTS:All three SMI inhibited cell proliferation and18F-FDG uptake in a dose-dependent manner and without significant cytotoxic effects.Furthermore,additive effects of the drugs were observed.Immunoblot analysis showed that sorafenib and sunitib,but not erlotinib,efficiently blocked activation of the AKT pathway,while all three drugs displayed little effect on phosphorylation of ERK1/2.Cells treated with sorafenib or sunitinib expressed less interleukin-6 mRNA as well as less collagen type 1 mRNA and protein.Sorafenib was the only drug that also upregulated the expression of matrix metalloproteinase-2 and reduced the secretion of TGF-β1 protein.All three drugs showed insignificant or discordant effects on the mRNA and protein levels ofα-SMA.CONCLUSION:The tested SMI,especially sorafenib,exert inhibitory effects on activated PSC,which should be further evaluated in preclinical studies. | Anne Elsner Falko Lange Brit Fitzner Martin Heuschkel Bernd Joachim Krause Robert Jaster | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 8 | Microarray Gene Expression of Hepatitis C Virus Hepatocellular Carcinoma显示文摘 | HEIKE V UTA D FALKO S | 2008 | Hepatology2008，47，： | 1 |
| 9 | Transient dominant selection of recombinant vaccinia viruses 显示文摘 | Falko G Bernardmoss F | 1990 | J Virol1990，64，6： | 1 |
| 10 | Influence of spray parameters on the particle in-flight properties and theproperties of HVOF coating of WC-CoCr显示文摘 | Lidong Zhao Matthias Maurer Falko Fischer | 2004 | Wear2004，257，： | 1 |
| 11 | A roadmap for graphene显示文摘 | Novoselov K S Falko V I Colombo L | 2012 | Nature2012，490，： | 1 |
| 12 | On the stability of different financial systems显示文摘 | Falko Fecht | 2004 | Journal of the European Economic Association2004，，6： | 1 |
| 13 | Preventive Health Behavior and Adaptive Accuracy of Risk Perceptions显示文摘 | Britta Renner Benjamin Schüz Falko F. Sniehotta | 2008 | An International Journal2008，，： | 1 |
| 14 | Clinical profile and outcomes of diabetic and nondiabetie patients in cardiac rehabilitation显示文摘 | HINDMAN L FALKO J M LALONDE M | 2005 | Am Heart J2005，150，5： | 1 |
| 15 | Optimalmanagement of lipids in diabetes and metabolic syndrome显示文摘 | BROWN W V CLARK L FALKO J M | 2008 | J Clin LipidoU2008，2，5： | 1 |
| 16 | Alterations in theparameters oflipid metabolism in different biological objects in psoriatic pa-tients during exacerbation and remission显示文摘 | B S Khyshiktuev E V Falko | 2005 | Vestnik Dermatolo-gii i Venerologii2005，6，： | 1 |
| 17 | Variability ofquantitative changes in short-chain fatty acids in the serum andepidermis in psoriasis显示文摘 | B S Khyshiktuyev T M Karavayeva Y V Falko | 2008 | Klinichescheskaya Laboratornaya Di-agnostika2008，8，： | 1 |
| 18 | Fibrosing pseudotumor of the sella and parasellar area producing hypopituitarism and multiple cranial nerve palsies显示文摘 | Olmos PR Falko JM Rea GL | 1993 | Neurosurgery1993，32，： | 1 |
| 19 | A roadmap for graphene显示文摘 | Novoselov K Falko V Colombo L | 2012 | Nature2012，490，7419： | 1 |
| 20 | Cardiovascular disease risk Qf type 2 diabetes mellitus and metabolic syndrome:focus on aggressive management of dyslipidemia显示文摘 | Falko JM Moser RJ Meis SB | 2005 | Curt Diabetes Rev2005，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员