|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessment of Bisphenol A(BPA) neurotoxicity in vitro with mouse embryonic stem cells显示文摘The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell(ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A(BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effects of BPA previously detected by in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells. | Nuoya Yin Xinglei Yao Zhanfen Qin Yuan-Liang Wang Francesco Faiola | 2015 | Journal of Environmental Sciences2015，27，10： | 9 |
| 2 | Oct4 links multiple epigenetic pathways to the pluripotency network显示文摘Oct4 是在干细胞自强, pluripotency,和体的房间 reprogramming 起基本作用的一个著名抄写因素。然而,有限信息在联系 Oct4 的蛋白质建筑群和他们支配 Oct4 的批评规章的活动的内在的蛋白质蛋白质相互作用上是可得到的。这里,我们采用了与集体 spectrometry 相结合在老鼠净化 Oct4 蛋白质建筑群的一条改进亲密关系纯化途径胚胎的干细胞(mESCs ) ,并且发现了为 mESCs 的自强和 pluripotency 重要的许多新奇 Oct4 搭挡。尤其是,我们发现那 Oct4 与多重修改染色质的建筑群被联系与记录以及最新在干细胞维护和体的房间 reprogramming 证明意义功能。我们的学习建立一个稳固的生物化学的基础为基因并且干细胞 pluripotency 的 epigenetic 规定并且为探索其他的基于因素的 reprogramming 策略提供一个框架。 | Junjun Ding HuileiXu Francesco Faiola Avi Ma'ayan Jianlong Wang | 2012 | Cell Research2012，22，1： | 6 |
| 3 | A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis显示文摘Air pollution has been linked to many health issues,including skin conditions,especially in children.Among all the atmospheric pollutants,ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin,and be absorbed into the bloodstream.Here,we employed a human embryonic stem cell(h ESC)-based differentiation system towards keratinocytes,to test the effects of ultrafine carbon particles,which mimic ambient ultrafine particles,at environment related concentrations.We found that10 ng/mL to 10μg/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in h ESCs.Moreover,1μg/mL to 10μg/mL carbon particle treatments disrupted the keratinocyte differentiation,and up-regulated inflammationand psoriasis-related genes,such as IL-1β,IL-6,CXCL1,CXCL2,CXCL3,CCL20,CXCL8,and S100 A7 and S100 A9,respectively.Overall,our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles. | Zhanwen Cheng Xiaoxing Liang Shaojun Liang Nuoya Yin Francesco Faiola | 2020 | Journal of Environmental Sciences2020，32，1： | 6 |
| 4 | Tetrabromobisphenol A(TBBPA): A controversial environmental pollutant显示文摘Tetrabromobisphenol A(TBBPA)is one of the most widely used brominated flame retardants and is extensively used in electronic equipment,furniture,plastics,and textiles.It is frequently detected in water,soil,air,and organisms,including humans,and has raised concerns in the scientific community regarding its potential adverse health effects.Human exposure to TBBPA is mainly via diet,respiration,and skin contact.Various in vivo and in vitro studies based on animal and cell models have demonstrated that TBBPA can induce multifaceted effects in cells and animals,and potentially exert hepatic,renal,neural,cardiac,and reproductive toxicities.Nevertheless,other reports have claimed that TBBPA might be a safe chemical.In this review,we re-evaluated most of the published TBBPA toxicological assessments with the goal of reaching a conclusion about its potential toxicity.We concluded that,although low TBBPA exposure levels and rapid metabolism in humans may signify that TBBPA is a safe chemical for the general population,particular attention should be paid to the potential effects of TBBPA on early developmental stages. | Hui Zhou Nuoya Yin Francesco Faiola | 2020 | Journal of Environmental Sciences2020，32，11： | 6 |
| 5 | Stem cell toxicology:a powerful tool to assess pollution effects on human health显示文摘Environmental pollution is a global problem;the lack of comprehensive toxicological assessments may lead to increased health risks.To fully understand the health efects of pollution,it is paramount to implement fast,eicient and speciic toxicity screening that relies on human models rather than on time-consuming,expensive and oten inaccurate tests involving live animals.Human stem cell toxicology represents a valid alternative to traditional toxicity assays because it takes advantage of the ability of stem cells to diferentiate into multiple cell types and tissues of the human body.hus,this branch of toxicology provides a possibility to assess cellular,embryonic,developmental,reproductive and functional toxicity in vitro within a single system highly relevant to human physiology.In this review,we describe the development,performance and future perspectives of stem cell toxicology,with an emphasis on how it can meet the increasing challenges posed by environmental pollution in the modern world. | Xinglei Yao Nuoya Yin Francesco Faiola | 2016 | National Science Review2016，3，4： | 2 |
| 6 | Bone marrow- generated dendritic cells pulsed with tumor extracts or tumor RNA induc ed antitumor immunity against central nervous system tumors显示文摘 | Ashley DM Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 2 |
| 7 | 基于美国FAERS数据库的拉米夫定妊娠相关不良反应信号挖掘研究显示文摘目的:利用美国FDA不良事件报告系统(FAERS)挖掘拉米夫定妊娠相关不良反应的风险信号,为该药的临床安全应用提供参考。方法:收集FAERS数据库中2004年第1季度-2021年第1季度的不良事件报告,根据首要怀疑药物,以替诺福韦酯为对照,利用报告比值比(ROR)法对拉米夫定妊娠相关不良事件(流产、自然流产、早产、低出生体重、死产和胎儿死亡、胎儿并发症)进行风险信号挖掘。并分别在HBV人群、HIV人群进行亚组分析。结果:以拉米夫定和替诺福韦酯为首要怀疑药物的妊娠期不良反应报告分别有4364例和3750例。与替诺福韦酯相比,拉米夫定妊娠相关不良反应风险信号未见升高。但在HBV人群中,拉米夫定所致的死产和胎儿死亡(ROR=2.09,95%CI:1.14~3.82)、胎儿并发症(ROR=3.04,95%CI:2.19~4.23)风险信号较替诺福韦酯显著增加,上述差异在HIV人群中并未观察到。结论:鉴于我国庞大的乙肝患者人群以及目前尚缺乏对两药妊娠期安全性的头对头系统性比较研究,基于FAERS的真实世界数据可为妊娠期乙肝患者个体化用药提供一定参考。 | 张杨 杨仁君 殷诺雅 赵莹 李丹丹 Francesco Faiola | 2022 | 中国药物应用与监测2022，19，3： | 2 |
| 8 | Bone marrow-generated den dritic cells pulsed with tumor extracts or tunor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 9 | Concise review: pursuing self- renewal and pluripotency with the stem cell factor nanog 显示文摘 | Saunders A Faiola F Wang J | 2013 | Stem Ceils2013，31，： | 1 |
| 10 | Exposure of hematopoietic stem cells to benzene or 1, 4-benzoquinone induces gender-specific gene expression 显示文摘 | Faiola B Fuller ES Wong VA | 2004 | Stem Cells2004，22，5： | 1 |
| 11 | Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo 显示文摘 | Porgador A Staats HF Faiola B | 1997 | J Immunol1997，158，2： | 1 |
| 12 | C, ene expression profile in bone marrow and hcmatopoietie stem cells in mice exposed to inhaled benzene 显示文摘 | FAIOLA B FULLER E S WONG V A ct al | 2004 | Mutat Res2004，549，12： | 1 |
| 13 | Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene显示文摘 | FAIOLA B FULLER ES WONG VA | 2004 | Mutation Res2004，549，12： | 1 |
| 14 | Custom made bioceramicimplants in complex and large cranial reconstruction : a two-year follow-up 显示文摘 | Staffa G Barbanera A Faiola A | 2012 | J Craniomaxillofac Surg2012，40，3： | 1 |
| 15 | Phase Ⅱ trial of temozolomide using protracted low-dose and whole-brain radiotherapy for non-small-cell lung cancer and breast cancer patients with brain metastases 显示文摘 | Addeo R De Rosa C Faiola V | 2008 | Cancer2008，113，9： | 1 |
| 16 | Genetic susceptibility tobenzene-induced toxicity: role of NADPH: quinone oxidoreductase- l显示文摘 | Bauer AK Faiola B Abemethy DJ | 2003 | Cancer Res2003，63，5： | 1 |
| 17 | Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity显示文摘 | Recio L Bauer A Faiola B | 2005 | Chem Biol Interact2005，，： | 1 |
| 18 | Likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13+6-week scan显示文摘 | Faiola S Tsoi E Huggon IC | | 0，，01： | 1 |
| 19 | Pursuing Self-renewal and pluripo- tency with the stem cell factor Nanog显示文摘 | Saunders A Faiola F Wang J | 2013 | Stem Ceils2013，31，7： | 1 |
| 20 | Delayed migration of a screw into the gastrointestinal tract after anterior cervical spine plating 显示文摘 | Gazzeri R Tamorri M Faiola A | 2008 | Spine (Phila Pa 1976)2008，15，33： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员