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| 1 | 肝衰竭诊疗指南显示文摘肝衰竭是临床常见的严重肝病症候群,病死率极高。多年来,各国学者对肝衰竭的定义、分类、诊断和治疗等问题不断进行探索,但迄今尚无一致意见。2005年美国肝病学会发布了对急性肝衰竭处理的建议,国内迄今尚无肝衰竭的诊断治疗指南。为适应临床工作需要,规范我国肝衰竭的诊断和治疗活动,中华医学会感染病学分会和中华医学会肝病学分会组织国内有关专家,制订了我国第一部《肝衰竭诊疗指南》(以下简称《指南》)。本指南的制定遵守了循证医学原则,借鉴了国内外最新研究成果,力求与国际接轨。其中推荐意见所依据的证据共分为3个级别5个等级(表1),文中以括号内斜体罗马数字表示。 | Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association | 2006 | 中华肝脏病杂志2006，14，9： | 827 |
| 2 | 肝衰竭诊疗指南显示文摘 | Liver Failure and Artficial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association | 2006 | 实用肝脏病杂志2006，9，6： | 188 |
| 3 | Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK显示文摘Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin.The expression of glomerular podocyte slit diaphragm(PSD)-associated proteins,nephrin and podocin,was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs.Chronic inhibi-tion of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats.This suggested that accumulation of AOPPs promotes proteinuria,possibly via down-regulating the expression of PSD-associated proteins. | YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. | 2010 | Science China(Life Sciences)2010，53，1： | 14 |
| 4 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 5 | The effect of carvedilol on morbidity and mortality in patients with chronic heart failure 显示文摘 | | 1996 | N Engl J Med1996，334，21： | 1 |
| 6 | K/DOQI,National Kidney Foundation显示文摘 | Clinical practice guidelines for nutrition in chronic renal failure | 2000 | Am J Kidney Dis2000，35，： | 1 |
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| 8 | Cytoskeletal remodeling 显示文摘 | Wang X Li F Campbell SE et ak Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: Ⅱ | 1999 | J Mol Cell Cardiol1999，31，： | 1 |
| 9 | Intensity of Renal Support in Critically Ⅲ Patients with Acute Kidney Injury显示文摘 | The VA/NIH Acute Renal Failure Trial Network | 2008 | N Engl J Med2008，359，1： | 1 |
| 10 | A controlled trial 显示文摘 | Kleinknecht D Ganeval D Gonzalez-Duque LA Furo-semide in acute oliguric renal failure | 1976 | Nephron1976，17，1： | 1 |
| 11 | ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008显示文摘 | The task Force for Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of European Society of Cardiology | 2008 | European Heart Journal2008，，29： | 1 |
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| 13 | A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure显示文摘 | Cohn JN Tognoni G Valsartan Heart Failure Trial Investigators | | 0，，23： | 1 |
| 14 | Randomised,placebo-controlled trial of carvedilol in patient with congestive heart failure due to iscbemic heart disease显示文摘 | | 1997 | Lancet1997，349，： | 1 |
| 15 | Guidelines for the diagnosis and treatment of chronic heart failure 显示文摘 | Task force for the diagnosis and treatment of chronic heart failure of European society of cardiology | 2002 | Eur Hear2002，4，1： | 1 |
| 16 | European best practice guidelines for the management of anaemia in patients with chronic renal failure显示文摘 | Working Party for European Best Practice Guidelines for the Management of Anaemia in Patients with Chronic Renal Failure | 1999 | Nephrol Dial Transplant1999，14，5： | 1 |
| 17 | K/DOQI,National Kidney Foundation 显示文摘 | Clinical practice guidelines for nutrition in chronic renal failure | 2000 | Am J Kidney Dis2000，35，： | 1 |
| 18 | Increased weight people with metabolic syndrome compared with metabolically healthy obese individuals显示文摘 | Voulgari C Tentolouris N heart failure risk in normal Dilaveris P | 2011 | J Am Coll Cardiol2011，58，13： | 1 |
| 19 | Consenesus recommendations for the management of chronic heart failure 显示文摘 | Advisory council in improve outcomes nationwide in heart failure | 1999 | Am J Cardiol1999，83，： | 1 |
| 20 | Guidelines for the diagnosis and treatment of chronic heart failure 显示文摘 | The Task Force for the Diagnosis and Treatment of Chronic Heart Failure European Society of Cardiology | 2001 | Eur Heart J2001，22，17： | 1 |
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