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| 1 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 2 | Inversion of local S-wave velocity structures from average H/V ratios, and their use for the estimation of site effects 显示文摘 | Fah D Kind F Giardini D | 2003 | Journal of Seismology2003，7，4： | 1 |
| 3 | Intestinal morphology,epithelial cell proliferation, and absorptive capacity in neonatal calves fed milk-born insulin-like growth factor-I or a colostrum extract 显示文摘 | Fah A Sauter S N | 2003 | J Dairy Sci2003，86，5： | 1 |
| 4 | Human sunlight-induced basal-cell-carcinoma-associated dendritic cells are different in T ecll co-stimulatory molecules and are impaired as antigen-presenting cells显示文摘 | Burg G Fah J | 1997 | Am J Pathol1997，150，： | 1 |
| 5 | A DNA-based approach to the identification of insect species used for postmortem interval estimation 显示文摘 | Sperling FAH Anderson GS Hickey DA | 1993 | Forensic Sci Int1993，39，4： | 1 |
| 6 | Heart rate recovery and heart rate complexity following resistance exercise training and de- training in young men 显示文摘 | Heffernan KS Fahs CA Shinsako KK | 2007 | Am J Physiol Heart Circ Physiol2007，293，5： | 1 |
| 7 | Uncertainty Analysis of Seepage-Induced Consolidation in a Fractured Porous Medium显示文摘Numerical modeling of seepage-induced consolidation process usually encounters significant uncertainty in the properties of geotechnical materials.Assessing the effect of uncertain parameters on the performance variability of the seepage consolidation model is of critical importance to the simulation and tests of this process.To this end,the uncertainty and sensitivity analyses are performed on a seepage consolidation model in a fractured porous medium using the Bayesian sparse polynomial chaos expansion(SPCE)method.Five uncertain parameters including Young’s modulus,Poisson’s ratio,and the permeability of the porous matrix,the permeability within the fracture,and Biot’s constant are studied.Bayesian SPCE models for displacement,flow velocity magnitude,and fluid pressure at several reference points are constructed to represent the input-output relationship of the numerical model.Based on these SPCE models,the total and first-order Sobol’indices are computed to quantify the contribution of each uncertain input parameter to the uncertainty of model responses.The results show that at different locations of the porous domain,the uncertain parameters show different effects on the output quantities.At the beginning of the seepage consolidation process,the hydraulic parameters make major contributions to the uncertainty of the model responses.As the process progresses,the effect of hydraulic parameters decreases and is gradually surpassed by the mechanical parameters.This work demonstrates the feasibility to apply Bayesian SPCE approach to the uncertainty and sensitivity analyses of seepage-induced consolidation problems and provides guidelines to the numerical modelling and experimental testing of such problems. | Lingai Guo Marwan Fahs Hussein Hoteit Rui Gao Qian Shao | 2021 | Computer Modeling in Engineering & Sciences2021，，10： | 1 |
| 8 | A DNA-based approach to the identification of insect species used for postmorten interval estimation 显示文摘 | Sperlhng FAH Anderson GS Hickey AD | 1994 | J Forensic Sci1994，39，： | 1 |
| 9 | Interferonregulated Mx genes are not responsive to interleukin- 1, tumor necrosis factor, and other cytokines 显示文摘 | SIMON A FAH J HALLER O | 1991 | J Virol1991，65，2： | 1 |
| 10 | Decision science and cervical cancer显示文摘 | Cantor SB Fahs MC Mandelblau JS | 2003 | Cancer2003，98，9： | 1 |
| 11 | Construction load analysis for concrete structures显示文摘 | Liu Xi L Chen Wai Fah Bowman M D | 1985 | ASCE Journal of Structural Engineering1985，111，5： | 1 |
| 12 | Identifying 2D Reso- nance in Microtremor Wave Fields 显示文摘 | STEINEM S FAH D KIND F | 2003 | Bulletin of the Seismological Society of America2003，93，2： | 1 |
| 13 | cDNA structures and regulation of two interferon-induced human Mx proteins显示文摘 | Aebi M Fah J Hurt N | 1989 | J Mol Cell Biol1989，9，： | 1 |
| 14 | Hemodynamic and vascular re- sponse to resistance exercise with L-arginine 显示文摘 | Fahs CA Heffernan KS Fernhall B | 2009 | Med Sci Sports Exerc2009，41，4： | 1 |
| 15 | Muhiple endocrine neoplasia type 2 显示文摘 | Marini F Fah'hetti A Del Monte F | 2006 | Orphanel J Rar Dis2006，1，： | 1 |
| 16 | cDNA structures and regulation of two interferon-induced human Mx proteins显示文摘 | Aebi M Fah J Hurt N | 1989 | J Mol Cell Biol1989，9，： | 1 |
| 17 | Decision science and cervical cancer显示文摘 | CANTOR S B FAHS M C MANDELBLA3F J S | 2003 | American Canc- er Soc2003，1002，10： | 1 |
| 18 | Integrative research review of risk behaviors among adolescents in rural,suburban,and urban areas显示文摘 | Fahs PS Smith BE Atav AS | 1999 | J Adolesc Health1999，24，4： | 1 |
| 19 | A family of interferon-induced Mai-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells显示文摘 | Meier E Fah J Grob MS | 1988 | J Virol1988，62，7： | 1 |
| 20 | Engine fault analysis,part:statistical methods显示文摘 | SOOD A K FRIENDLANDER C B FAHS A A | 1985 | IEEE Trans on Industrial Electronies1985，32，4： | 1 |
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