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| 1 | Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?显示文摘AIM To evaluate the prevalence of nodular lymphoid hyperplasia(NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome(IBS)-type symptoms or suspected inflammatory bowel disease(IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening.Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period.RESULTS One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals(only 3%), while it was significantly more prevalent in symptomatic cases(32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. | Anna Chiara Piscaglia Lucrezia Laterza Valentina Cesario Viviana Gerardi Rosario Landi Loris Riccardo Lopetuso Giovanni Calò Giovanna Fabbretti Massimo Brisigotti Maria Loredana Stefanelli Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，46： | 2 |
| 2 | Molecular mechanisms of sensitization of pain-transducing P2X3receptors by the migraine mediators CGRP and NGF显示文摘 | Giniatullin R Nistri A Fabbretti E | 2008 | Mol Neurobiol2008，37，1： | 1 |
| 3 | Mechanisms mediating the enhanced gene transcription of P2X3receptor by calcitonin gene-related peptide in trigeminal sensory neurons显示文摘 | Simonetti M Giniatullin R Fabbretti E | 2008 | J Biol Chem2008，283，18： | 1 |
| 4 | Delayed upregulation of ATP P2X3receptors of trigeminal sensory neurons by calcitonin gene-related peptide显示文摘 | Fabbretti E D’Arco M Fabbro A | 2006 | J Neurosci2006，26，23： | 1 |
| 5 | Metanephric adenoma 显示文摘 | Brisigotti M Cozzuto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 6 | The Cdk5 Kinase Downregulates ATP-Gated Ionotropic P2X3 Receptor Function Via Serine Phosphorylation显示文摘 | Asha Nair Manuela Simonetti Elsa Fabbretti Andrea Nistri | 2010 | Cellular and Molecular Neurobiology2010，，4： | 1 |
| 7 | Metanephric adenoma显示文摘 | Brisigotti M Cozzutto C Fabbretti G | | 0，，： | 1 |
| 8 | Metanephric adenomal显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 9 | Astory description task in children with Down' s syndrome:lexical and morphosyntactic abilities显示文摘 | Fabbretti D Pizzuto E Vicari S Volterra V | | 0，，41： | 1 |
| 10 | Metanephric adenoma 显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 11 | Metanephric adenoma显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 12 | Metanephric adenoma 显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 13 | Exocytotic release of ATP from cultured astrocytes 显示文摘 | Pangrsic T Potokar M Stenovec M Kreft M Fabbretti E Nistri A | 2007 | J Biol Chem2007，282，28： | 1 |
| 14 | Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by ealeitonin gene - related peptide显示文摘 | Fabbretti E D'Arco M Fabbro A | 2006 | J Neurosei2006，26，： | 1 |
| 15 | Metanephric adenoma显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 16 | Regulation of P2X3 receptor structure and function 显示文摘 | Fabbretti E Nistri A | 2012 | CNS Neuro| Disord Drug Targets2012，11，6： | 1 |
| 17 | Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trlgeminal sensory neurons 显示文摘 | Simonetti M Giniatullin R Fabbretti F | 2008 | J Biol Chem2008，283，18： | 1 |
| 18 | Metanephric Adenoma 显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 19 | Metanephric adenoma显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
| 20 | Metanephric adenoma显示文摘 | Brisigotti M Cozzutto C Fabbretti G | 1992 | Histol Histopathol1992，7，4： | 1 |
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