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| 1 | 静脉血栓栓塞研究的既往与现今及未来显示文摘静脉血栓栓塞症(VTE)是继冠心病和中风后排名第三的最常见的心血管疾病。在过去的100年中,对于血液凝固过程及其调控机制的深入了解推进了VTE的诊断和治疗方法。1860年制定的魏尔肖三定律直今仍然是有效的,即VTE是由于血管壁受损、血液流动减慢和血液成分改变造成的。流行病学和临床科学现在也已经确定了V‘rE的多个后天获得性危险因素,如高龄、肿瘤、手术、外伤、固定、怀孕和使用口服避孕药等。随着遗传研究技术的快速发展,一些基因被确定与VTE的家族聚集性有关,与VTE相关的基因变异也逐渐被发现。遗传因素和后天获得性的危险因素在血栓的发展中相互作用。新型实验诊断项目能够帮助人们早期判断高凝状态。因此,为减少全球VTE负担,对VTE的预防,风险评估,诊断和治疗将更为重要。 | Bengt Zoller Pablo Garcia de Frutos Bjorn Dahlback 吴俊 | 2016 | 中华检验医学杂志2016，39，10： | 6 |
| 2 | 球形芽孢杆菌C_3-41二元毒素基因在苏云金芽孢杆菌以色列亚种中的克隆和表达显示文摘球形芽孢杆菌C341是我国分离的一株对蚊幼虫有毒杀作用的高毒力菌株,对库蚊、按蚊幼虫的毒性高于2362菌株,Southern杂交证明C341总DNA中35KbHindII片段上带有419和514kD二元毒素基因,该片段由3479个核苷酸组成,核苷酸序列同2362菌株的二元毒素基因序列完全相同。含二元毒素基因的重组质粒pCW1和pCW2能在大肠杆菌中表达产生二元毒素蛋白,但表达量低,重组子杀蚊毒性低。无晶体型苏云金芽孢杆菌以色列亚种重组子在其芽孢形成中能产生以晶体形式存在的二元毒素蛋白,其全发酵液和纯化晶体蛋白的杀蚊活性与C341相近。 | 袁志明 Nielsen-LeRoux C Pasteur N Delecluse A Charles J-F Frutos R | 1999 | 微生物学报1999，39，1： | 5 |
| 3 | Randomized Prospective Study to Compare Laparoscopic Appendectomy Versus Umbilical Single-Incision Appendectomy显示文摘 | Ma Dolores Frutos Jesus Abrisqueta Juan Lujan Israel Abellan Pascual Parrilla | 2013 | Annals of Surgery2013，，3： | 3 |
| 4 | Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam显示文摘Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2. | Pham Thi Kim Lien Vu Trong Duoc Laurent Gavotte Emmanuel Cornillot Phan Thi Nga Laurence Briant Roger Frutos Tran Nhu Duong | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 2 |
| 5 | Genetic loss of Gas 6 induces plaque stability in experimental atherosclerosis显示文摘 | Lutgens E Tjwa M de Frutos PG | 2008 | J Pathol2008，216，1： | 1 |
| 6 | cy or inhibition of Gas6 causes platelet dysfunctionand protects mice against thrombosis 显示文摘 | Angelillo-Scherrer A de Frutos P Aparicio C | 2001 | Nat Med2001，7，2： | 1 |
| 7 | Inhibition of Alzheimer β-peptide fibril formation by serum amyloid P component显示文摘 | Garcia de Frutos P Carlemalm E | 1995 | J Biol Chem1995，270，26： | 1 |
| 8 | Enhancement of the mydriatic response to tropicamide by bioadhesive polymers显示文摘 | Herrero VR Fernandez CA Frutos G | 2000 | J Ocul Pharmacol Ther2000，16，5： | 1 |
| 9 | Expression of endothelial type nitric oxide synthetase isoform in human neutrophils:modification by tumor necrosis factor alpha and during acute myocardial infarction显示文摘 | Frutos T Sanche de Miguel L Farre J | 2001 | JACC2001，37，3： | 1 |
| 10 | Development of an immunochromatographic method to determineβ–lactoglobulin at trace levels显示文摘 | Puerta A Diez–Masa J C Frutos M | 2005 | Analytica Chimica Acta2005，537，： | 1 |
| 11 | Genetic loss ofGas6 induces plaque stability in experimental atherosclerosis显示文摘 | Lutgens E Tjwa M Garcia de frutos P | 2008 | J Pathol2008，216，1： | 1 |
| 12 | Noninvasive positive-pressure ventilation for respiratory failure after extubation显示文摘 | Esteban A Frutos Vovar F Ferguson ND | 2004 | N Eng J Med2004，350，24： | 1 |
| 13 | Deveolopment of an immunochromatographic method to determine β- lactoglobulin at trace levels 显示文摘 | Angel Puerta Jose Carlos Diez-Masa Mercedes de Frutos | 2005 | Analytica Chimica Acta2005，537，： | 1 |
| 14 | Oxidation behavior of AISI 316 steel coated by hot dipping in an A1-Si alloy 显示文摘 | Frutos E Adeva P Gonzalez- Carrasco J L | 2013 | Surface and Coatings Technology2013，236，： | 1 |
| 15 | Insect pathogens as biological control agents: Do they have a future 显示文摘 | Lacey L A Frutos R Kaya H A | 2001 | Biological Control2001，21，： | 1 |
| 16 | Blocking EphrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth显示文摘 | Abngozar MA de Frutos S Ferreiro S etal | 2012 | Blood2012，119，19： | 1 |
| 17 | Intravenous cyclophos-phamide in lupus nephritis:twenty years reducing dose显示文摘 | Frutos MA Martin GA de Ramon E | 2007 | Nefrologia2007，27，1： | 1 |
| 18 | Demonstration of a word design strategy for DNA computing on surfaces显示文摘 | FRUTOS A G LIU Q | 1997 | Nucleic Acids Research1997，25，23： | 1 |
| 19 | A comparison of four methods of weaning patients from mechanical ventilation显示文摘 | Esteban A Frutos F Tobin MJ | 1995 | N Engl Med1995，332，： | 1 |
| 20 | Nonlinear I-V electrical behaviour of doped CaCu3Ti4O12 ceramics显示文摘 | LERET P FEMANDEZ J F FRUTOS J | | 0，，27： | 1 |
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