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163篇 您的检索式:作者名="FRIEDL P"
    题名 作者 年代 出处 被引量
1家族性腺瘤样息肉病中APC基因的胚系突变分析(英文)显示文摘目的探索有效的突变检测技术,系统分析家族性腺瘤样息肉病(familialadenomatouspolyposis,FAP)相关基因结肠腺瘤病(adenomatouspolyposiscoli,APC)基因的胚系突变,及其与疾病表型的关系。方法从22例临床确诊的FAP患者,外周静脉血中提取基因组DNA。变性高效液相色谱、蛋白截短检测、测序技术结合应用进行全基因分析。根据患者临床资料,进行基因型表型分析。结果22例FAP患者中13例检出APC基因胚系突变,均为无义或移码突变。基因型-表型关系的初步分析表明,在基因5′端或3′端发生突变的患者临床症状较轻,在基因中段发生突变的患者临床症状典型或严重。结论本研究中所采用的技术体系可敏感、高效地检出APC基因突变,APC基因的突变型与FAP患者的临床表型存在关联,所采用的技术体系适用于FAP症状出现前的基因诊断。刘晓蓉 单祥年 Friedl W Uhlhaas S Propping P 王亚平 2005中华医学遗传学杂志2005,22,3:12
2Tube travel:the role of proteases in individual and collective cancer cell invasion显示文摘Friedl P Wolf K 2008Cancer Res2008,68,18:1
3Serum-and protein-free media formulations for the Chinese hamster ovary cell line DUKXB11显示文摘Sehroder M Matischak K Friedl P 2004Journal of Biotechnology2004,108,3:1
4Tumor antigen pulsed dendrit- ic cells enhance the cytolytic activity of tumor infiltrating lym- phocytes in human hepatocellular cancer显示文摘Friedl J Stilt A Paolini P 2000Cancer Biother Radiopharm2000,15,5:1
5Dendritic cell-based vaccination !n solid cancer显示文摘Stift A Friedl J Dubsky P 2003J Clin Oncol2003,21,1:1
6Collective cell migration in morphogenesis,regeneration and cancer显示文摘Friedl P Gilmour D 2009Nature Reviews Molecular Cell Biology2009,10,7:1
7Ureterosigmoidostomy:long term results,risk of carcinoma and etiological factors for carcinogenesis显示文摘KALBLE T TRICKER A R FRIEDL P 1990J Urol1990,144,5:1
8Decreased accessibilityand lack of activation of ErbB2 in JIMT-1,a herceptin-resist-ant,MUC4-expressing breast cancer cell line显示文摘Nagy P Friedl?nder E Tanner M 2005Cancer Res2005,65,2:1
9Tumour cell invasion and migration:diversity and escape mechanisms显示文摘Friedl P Wolf K 2003Nat Rev Cancer2003,3,:1
10Isolation and long-term cultivation of human corneal endothelial cells显示文摘Engelmann K Bohnke M Friedl P 1988Investigative Ophthalmology & Visual Science1988,29,11:1
11Haemophilus parasuis invades porcine brain microvascular endothelial cells显示文摘Vanier G Szczotka A Friedl P 2006Microbiology2006,,:1
12Adherence ofStreptococcus suis to Porcine Endothelial Cells 显示文摘BENGA L FRIEDL P VALENTIN-WEIGAND P 2005J Vet Med B2005,52,:1
13Lack of hemodynamic forces triggers apoptosis in vascular endothelial cells 显示文摘KaiserD FreybergM A Friedl P 1997BiochemBiophys Res Com- mun1997,231,3:1
14Prespeeifieation and plasticity:Shifting mechanisms of cell migration 显示文摘FRIEDL P 2004Current Opinion Cell Biology2004,16,1:1
15Dendritic cell-based vaecina tion in solid cancer显示文摘Stilt A Friedl J Dubsky P 2003J Clin Oncol2003,21,1:1
16Tumour-cell invasion and migration:diversity and escape mechanisms显示文摘Friedl P Wolf K 2003Nat Rev Cancer2003,3,:1
17Adherence of Streptococcus suis to Porcine Endothelial Cells显示文摘Benga L Friedl P Valentin-Weigand P 2005Journal of Veterinary Medicine2005,52,:1
18Collective cell migration in morphogenesis ,re- generation and cancer 显示文摘Friedl P Gilmour D 2009Nat Rev Mol Cell Biol2009,10,7:1
19Tumor-cell invasion and migration :diversity and escape mechanisms显示文摘Friedl P Wolf K 2003Nat Rev Cancer2003,3,5:1
20Haemophilus parasuis invades porcine brain microvascular endothelial cells显示文摘Vanier G Szczotka A Friedl P 2006Microbiology2006,152,1:1
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