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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | Optical resolution through a randomly inhomogeneous medium显示文摘 | Fried D L | 1966 | J Opt Soc Am1966，56，13： | 2 |
| 4 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 5 | Immunological priming with synthetic peptides of foot-and-mouth disease virus 显示文摘 | Francis M J Fry C M Rowlands D J | 1985 | J Gen Virol1985，66，： | 2 |
| 6 | Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease显示文摘 | Renata D’Incà Elisabetta Pont Vincenza Leo Antonio Ferronato Walter Fries Maria Grazia Vettorato Diego Martines Giacomo Carlo Sturniolo | 2007 | International Journal of Colorectal Disease2007，，4： | 2 |
| 7 | Bose-Einstein condensation of atomic hydrogen显示文摘 | FRIED G D KILLIAN T C WILLMANN L | 1998 | Phys Rev Lett1998，81，18： | 2 |
| 8 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 9 | Light scattering properties of natural and artificially demineralized dental enamel at 1 310 nm显示文摘 | DARLING C L HUYNH G D FRIED D | 2006 | Journal of Biomedical Optics2006，11，3： | 1 |
| 10 | Bayesian network classifieR显示文摘 | FRIED S GEIGER D GOLDSZMIDT M | 1997 | Machine Learning1997，29，： | 1 |
| 11 | Observation of a chicken embryo lethal orphan (CELO) virus 显示文摘 | Yates V J Fry D E | 1957 | Am J Vet Res1957，18，： | 1 |
| 12 | Anticancer therapy targeting the erbB family of receptor tyrosine kinases显示文摘 | Slichenmyer W J Fry D W | 2001 | Semin Oncol2001，28，16： | 1 |
| 13 | Structure and recepter binding显示文摘 | Jackson T Stuart D I Fry E | 2003 | J Virol2003，91，： | 1 |
| 14 | Endometriosis and geneticpolymorphisms显示文摘 | Falconer H D Hooghe T Fried G | 2007 | Obstet Gynecol Surv2007，62，9： | 1 |
| 15 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 16 | Optical resolution through a randomly inhomogeneous medium for very long and very short exposures 显示文摘 | Fried D L | 1966 | J Opt Soc Am1966，56，10： | 1 |
| 17 | Emerging treatment strategies for trauma- induced coagulopathy 显示文摘 | Sorensen B Fries D | 2012 | BrJ Surg2012，991，： | 1 |
| 18 | Managerial power and rent extraction in the design of executive compensation显示文摘 | BEBCHUK L FRIED J WALKER D | 2002 | University of Chicago Law Review2002，69，： | 1 |
| 19 | Structure and receptor binding显示文摘 | Jackson T Stuart D I Fry E | 2003 | Virus2003，91，： | 1 |
| 20 | Value of preoperative embolization of uterine fibroma: report of a multicenter series of 31 cases显示文摘 | Ravina JH Bouret JM Fried D | 1995 | Contracept Fertile Sex1995，23，： | 1 |
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