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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | Letter recognition using Holland-style adaptive classifiers显示文摘 | Frey P W Slate D J | 1991 | Machine Learning1991，6，2： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Use of allozymes as genetic marker for predicting genetic performance in maize single cross hy- brids显示文摘 | Frei 0 M Stuber C W Goodman M M | 1986 | Crop Sei1986，26，1： | 1 |
| 6 | An ap- proach to automatic three-dimensional finite element mesh generation显示文摘 | CAVENDISH J C FIELD D A FREY W H | 1985 | International Journal for Numerical Methods in Engineering1985，21，2： | 1 |
| 7 | Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol显示文摘 | STOCKER R BOWRY V W FREI B | 1991 | Proc Natl Acad Sci USA1991，88，5： | 1 |
| 8 | Preparation of submicron-scale,electrospun cellulose fibers via direct dissolution显示文摘 | CHOO Won Kim MARGARET W Frey MANUEL Marquez | 2005 | Pulymer Physics2005，，43： | 1 |
| 9 | Letter Recognition Using Holland-Style Adaptive Classifiers显示文摘 | Frey P W Slate D J | 1991 | Machine Learning1991，6，2： | 1 |
| 10 | In creased serum levels of non-collagenous matrix proteins ( cartilage oligomeric matrix protein and melanoma inhibitory activity)in marathon runners 显示文摘 | Neidhart M Muller-Ladner U Frey W | 2000 | Osteoarthritis Cartilage2000，8，3： | 1 |
| 11 | Small is Interesting显示文摘 | Frey W H | 2004 | The Milken Institute Review2004，，2： | 1 |
| 12 | The Hidden Econ- omy: State and Prospects for Measurement显示文摘 | Frey B S Pommerene W W | 1984 | Review of Income and Wealth1984，30，1： | 1 |
| 13 | Fluctuations in Pre- cambrian atmospheric oxygenation recorded by chromium iso- topes显示文摘 | Frei R Gaucher C Poulton S W | 2009 | Nature2009，461，： | 1 |
| 14 | Image Enhancement by Histogram Hyperbolisation 显示文摘 | W Frei | 1977 | Computer Graphics and Image Processing1977，6，3： | 1 |
| 15 | In situ fluorescence spectroscopy of pesticides and other organic pollutants显示文摘 | Mallet V N Belliveau P E Frei R W | | 0，，： | 1 |
| 16 | Inactivation of pseudomone,s putida by pulsed electric field treatment: a study on the correlation of treatment parameters and inactivation efficiency in the short-pulse range显示文摘 | FREY W GUSBETH C SCHWARTZ T | 2013 | J Membr Biol2013，246，10： | 1 |
| 17 | Plasma membrane voltage changes during nanosecond pulsed electric field exposure 显示文摘 | Frey W White J A Price R O | 2006 | Biophysical Journal2006，90，10： | 1 |
| 18 | Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells显示文摘 | Lieb T Frei C W Frohock J I | 2002 | J Physiol2002，538，： | 1 |
| 19 | Intranasal delivery of neurotrophic factors BDNF,CNTF,EPO,and NT-4 to the CNS显示文摘 | Alcalá-Barraza S R Lee M S Hanson L R McDonald A A Frey W H 2nd McLoon L K | | 0，，： | 1 |
| 20 | Letter Recognition Using Holland-Style Adaptive Classifiers显示文摘 | Frey P W Slate D J | 1991 | Machine Learning1991，6，2： | 1 |
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