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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Data mining with an ant colony optimization algorithm显示文摘 | Parpinelli R S Lopes H S Freitas A A | 2002 | IEEE Trans Evolutionary Compute2002，6，4： | 1 |
| 3 | Effects of roads,topography,and land use on forest cover dynamics in the BrazilianAtlantic Forest显示文摘 | FREITAS S R HAWBAKER T J METZGER J P | 2010 | Forest Ecology and Management2010，259，3： | 1 |
| 4 | Influence of the degree of polymerisation in the ability of catechins to act as anthocyanin copigments显示文摘 | Gonzilez-Manzano S Mateus N de Freitas V Santos-Buelga C | 2008 | European Food Research and Technology2008，227，： | 1 |
| 5 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 6 | Volume visaalization and exploration through flexible transfer function design显示文摘 | Francisco de M Pinto Carla M D S Freitas | 2008 | Computers & Graphics2008，，32： | 1 |
| 7 | Expression of metalloproteinases and theirinhibitors in blood vessels in human endometrium显示文摘 | Freitas S Meduri G Le-Nestour E | 1999 | Biol Reprod1999，61，4： | 1 |
| 8 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 9 | Detection of new art-4 and arr-5 gene cassettes in clinical Pseudomonas aerugi-nosa and Klebsiella pneumoniae strains from Brazil显示文摘 | da Fonseca EL Freitas Fdos S de Amorim JC | | 0，，05： | 1 |
| 10 | External validation of a classification for methylene blue magnification chromoendoscopy in premalignant gastric lesions显示文摘 | Miguel Areia Pedro Amaro Mário Dinis-Ribeiro Maria Augusta Cipriano Carol Marinho Altamiro Costa-Pereira Carlos Lopes Luís Moreira-Dias José Manuel Rom?ozinho Hermano Gouveia Diniz Freitas Maximino Correia Leit?o | 2008 | Gastrointestinal Endoscopy2008，，7： | 1 |
| 11 | Polymerization of ethylene: some aspects of metallocene cata- lyst stabilization under homogeneous and heterogeneous reac- tion conditions显示文摘 | de Freitas A J D dos Santos J H Z Meneghetti S M P | 2011 | J Appl Poiym Sci2011，119，5： | 1 |
| 12 | The effect of microstructure and environment on fatigue crack growth in 7049 alloy at negative stress ratios显示文摘 | Fonte Mda Romeiro F Freitas Mde Stanzl-Tschegg S E Tchegg E K Vasudevan A K | 2003 | Int J Fatigue2003，25，： | 1 |
| 13 | Raman amplifier performance of dispersion compensating fibers 显示文摘 | CANI S P N FREITAS M ALMEIDA R T R | 2003 | Microwave and Optoelectronics Conference2003，，2： | 1 |
| 14 | Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappa B activation显示文摘 | de Freitas M S Spohr T C Benedito A B | 2002 | Brain Res2002，958，： | 1 |
| 15 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 16 | A pathology potpourri from the NOAA mussel watch program显示文摘 | Hillman R E Boehm P D Freitas S Y | 1988 | Shellfish Res1988，7，： | 1 |
| 17 | Source apportionment of fine and coarse particulate matter in a suburban area at the Western European Coast 显示文摘 | Almeida S M PioC A Freitas M C | 2005 | Atmospheric Environment2005，39，17： | 1 |
| 18 | Linear lupus erythematosus pro- fundus as an initial manifestation of systemic lupus erythematosus in a child显示文摘 | Fernandes S Santos S Freitas I | 2014 | Pediatric dermatology2014，31，3： | 1 |
| 19 | Multivariate analysis of nystatin and metronidazole in a semi-solid matrix by means of diffuse reflectance NIR spectroscopy and PLS regression 显示文摘 | Baratieri S C Barbosa J M Freitas M P | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，40： | 1 |
| 20 | Microencapsulation by solvent extraction/evaporation:reviewing the state of the art of microsphere preparation process technology显示文摘 | Freitas S Merkle HP Gander B | 2005 | J Controlled Release2005，102，2： | 1 |
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