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| 1 | Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population显示文摘BACKGROUND Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially regarding intermediate-grade(BCLC-B)tumors.The recently proposed Hong Kong liver cancer(HKLC)staging system appears useful but requires validation in Western populations.AIM To evaluate the agreement between BCLC and HKLC staging on the management of HCC in a Western population,estimating the overall patient survival.METHODS This was a retrospective study of HCC patients treated at a university hospital in southern Brazil between 2011 and 2016.Demographic,clinical,and laboratory data were collected.HCC staging was carried out according to the HKLC and BCLC systems to assess treatment agreement.Overall survival was estimated based on the treatment proposed in each system.RESULTS A total of 519 HCC patients were assessed.Of these,178(34.3%)were HKLC-I;95(18.3%)HKLC-IIA;47(9.1%)HKLC-IIB;29(5.6%)HKLC-IIIA;30(5.8%)HKLCIIIB;75(14.4%)HKLC-IV;and 65(12.5%)HKLC-V.According to the BCLC,25(4.9%)were BCLC-0;246(47.4%)BCLC-A;107(20.6%)BCLC-B;76(14.6%)BCLCC;and 65(12.5%)BCLC-D.The general agreement between the two systems was 80.0%-BCLC-0 and HKLC-I(100%);BCLC-A and HKLC-I/HKLC-II(96.7%);BCLC-B and HKLC-III(46.7%);BCLC-C and HKLC-IV(98.7%);BCLC-D and HKLC-V(41.5%).When sub-classifying BCLC-A,HKLC-IIB,HKLC-IIIA and HKLC-IIIB stages according to the up-to-7 in/out criterion,13.4,66.0,100 and 36.7%,respectively,of the cases were classified as up-to-7 out.CONCLUSION In a Western population,the general agreement between the two systems was 80.0%,although in BCLC-B cases the agreement was low,suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC.The authors suggest that the BCLC system should be routinely employed,although for BCLC-B cases it should be associated with the HKLC system. | Laura Bainy Rodrigues de Freitas Larisse Longo Deivid Santos Ivana Grivicich Mário Reis Alvares-da-Silva | 2019 | World Journal of Hepatology2019，11，9： | 3 |
| 2 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 3 | The fusogenic state of Mayaro virus induced by low pH and by hydrostatic pressure显示文摘 | Freitas M Da Poian AT Barth OM | 2006 | Cell Biochem Biophys2006，44，3： | 1 |
| 4 | The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation 显示文摘 | Freitas A M Schor N Boim M A | 2002 | BJU lnt2002，89，9： | 1 |
| 5 | Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus :efficacy and risk of ftmgal over - infection显示文摘 | Gonzalez - Garcia A Diniz - Freitas M Gandara - Vila P | 2006 | Oral Dis2006，12，6： | 1 |
| 6 | Mitochondria directly influence fertilisation outcome in the pig 显示文摘 | EI Shourbagy SH Spikings EC Freitas M | 2006 | Reproduction2006，131，2： | 1 |
| 7 | Sequential Monte Carlo methods to train neural network models 显示文摘 | De FREITAS J F G NIRANJAN M GEE A H | 2000 | Neural Computation2000，12，4： | 1 |
| 8 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 9 | Treatment of astigmatism during phacoemulsification 显示文摘 | Freitas G O Boteon J E Carvalho M J | 2014 | Arq Bras Ofta-tool2014，77，1： | 1 |
| 10 | Volume visaalization and exploration through flexible transfer function design显示文摘 | Francisco de M Pinto Carla M D S Freitas | 2008 | Computers & Graphics2008，，32： | 1 |
| 11 | Intracranial arterial stenting for symptomatic stenosis: a Latin American experience 显示文摘 | Freitas JM Zenteno M Aburto-Murrieta Y | 2007 | Surg Neurol2007，68，4： | 1 |
| 12 | Rheology and microstructural development of a Al-4%Cu alloy in the semi-solid state显示文摘 | Ferrante M Freitas E de | 1999 | Materials Science and Engineering A1999，271，： | 1 |
| 13 | External validation of a classification for methylene blue magnification chromoendoscopy in premalignant gastric lesions显示文摘 | Miguel Areia Pedro Amaro Mário Dinis-Ribeiro Maria Augusta Cipriano Carol Marinho Altamiro Costa-Pereira Carlos Lopes Luís Moreira-Dias José Manuel Rom?ozinho Hermano Gouveia Diniz Freitas Maximino Correia Leit?o | 2008 | Gastrointestinal Endoscopy2008，，7： | 1 |
| 14 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 15 | Polymerization of ethylene: some aspects of metallocene cata- lyst stabilization under homogeneous and heterogeneous reac- tion conditions显示文摘 | de Freitas A J D dos Santos J H Z Meneghetti S M P | 2011 | J Appl Poiym Sci2011，119，5： | 1 |
| 16 | Influence of metal resist- ant-plant growth-promoting bacteria on the growth of Ricinus communis in soil contaminated with heavy metals 显示文摘 | Rajkumar M Freitas H | 2008 | CbemosDhere2008，7，5： | 1 |
| 17 | Raman amplifier performance of dispersion compensating fibers 显示文摘 | CANI S P N FREITAS M ALMEIDA R T R | 2003 | Microwave and Optoelectronics Conference2003，，2： | 1 |
| 18 | Microbial populatiot response to changes of the operating conditions in a dynamic nutrient-removal sequencing batch reactor显示文摘 | Freitas F Temudo M Reia M A M | 2005 | Bioproces and Biosystems Engineering2005，28，3： | 1 |
| 19 | Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain 显示文摘 | FREITAS R ZHANG G COHN M J | 2007 | PLoS One2007，2，8： | 1 |
| 20 | Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappa B activation显示文摘 | de Freitas M S Spohr T C Benedito A B | 2002 | Brain Res2002，958，： | 1 |
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