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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Limbal relaxing incisionsto correct comea a- stigmatism during phaeoemulsifieation 显示文摘 | Carvalho MJ Suzuki SH Freitas LL | 2007 | JRe - fraet Surg2007，23，5： | 1 |
| 3 | The impact of the 2005 International Society of Urological Pathology consensus conference on standard Gleason grading of prostatic carcinoma in needle biopsies 显示文摘 | Billis A Guimaraes MS Freitas LL | 2008 | J Urol2008，180，2： | 1 |
| 4 | Post-operative w avefront analysis and contrast sensitivity of a multifo-cal apodized diffractive IOL(ReSTOR)and three monofocal IOLs显示文摘 | Rocha KM Chalita MR Souza CE Soriano ES Freitas LL | 2005 | J Refract Surg2005，21，6： | 1 |
| 5 | Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation显示文摘 | Freitas LL Araujo VC Martins MT | 2005 | Int J Surg Pathol2005，13，4： | 1 |
| 6 | Intracapsular dexamethasone implant in patients undergoing phacoemulsification and intraocular lens implantation 显示文摘 | Vianna LM Freitas LL Nose W | 2013 | Arq Bras Oftalmol2013，76，4： | 1 |
| 7 | The impact of the 2005 international society of urological pathology consensus conference on standard Gleason grading of prostatic carcinoma in needle biop- sies 显示文摘 | Billis A Guimaraes MS Freitas LL | 2008 | J Urol2008，180，： | 1 |
| 8 | Inflammatory atrophy on prostate needle biopsies:is there topographic relationship to cancer?显示文摘 | Billis A Freitas LL Magna LA | 2007 | Int Braz J Urol2007，33，： | 1 |
| 9 | Litubal relaxing incisions to correct corneal astigmatism during phacoemulsification显示文摘 | Carvalho MJ Suzuki SH Freitas LL | | 0，，： | 1 |
| 10 | Postoperative w avefront analysis and contrast sensitivity of a multifocal apodized diffractive IOL(ReSTOR)and three monofocal IOLs显示文摘 | Rocha KM Chalita MR Souza CE Soriano ES Freitas LL Muccioli C | 2005 | J Refract Surg2005，21，80： | 1 |
| 11 | Does the type of prostatic atrophy influence the association of extent of atrophy in needle biopsies and serum prostate-specific antigen levels显示文摘 | Billis A Meirelles L Freitas LL | 2009 | Urology2009，74，： | 1 |
| 12 | Limbal relaxing incisions to correct comeal astig- matism during phacoemulsification显示文摘 | CARVALHO MJ SUZUKI SH FREITAS LL BRANCO BC SCHOR P LIMA AL | 2007 | J Refract Surg2007，23，5： | 1 |
| 13 | Limbal relaxing incisions to correct corneal astigmatism during phacoemulsification显示文摘 | Carvalho MJ Suzukis SH Freitas LL | 2007 | J Refract Surg2007，23，5： | 1 |
| 14 | Limbal relaxing incisionsto correct corneal astigmatism during phacoemulsification显示文摘 | CarvalhoMJ Suzuki SH Freitas LL et al | 2007 | Refract Surg2007，23，5： | 1 |
| 15 | Visual performance of AcrySof ReSTOR apodized diffractive IOL: a prospective comparative trial 显示文摘 | Souza CE Muccioli C Soriano ES Chalita MR Oliveira F Freitas LL | 2005 | Am J Ophthalmol2005，141，5： | 1 |
| 16 | Visual acuity, contrast sensitivity, reading speed, and wavefront analysis: Pseudophakic eye with multifocal IOL ( Re-STOR) versus fellow phakic eye in non-presbyopic patients 显示文摘 | Souza CE Gerente VM Chalita MR Soriano ES Freitas LL Belfort R Jr | 2006 | J Refract Surg2006，22，3： | 1 |
| 17 | Postoperative wavefront analysis and contrast sensitivity of a multifocal apodized diffractive IOL(ReSTOR) and three monofocal IOLs 显示文摘 | Rocha KM Chalita MR Souza CE Soriano ES Freitas LL Muccioli C | 2005 | J Refract Surg2005，21，6： | 1 |
| 18 | Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats:a mechanism for diabetic chronic liver disease 显示文摘 | Lucchesi AN Freitas NT Cassettari LL | 2013 | Acta Cir Bras2013，28，7： | 1 |
| 19 | Performance of AcrySof ReSTOR apodized diffractive IOL: a prospective comparative trial Am 显示文摘 | Souza CE Muccioli C Sofiano ES Chalita MR Oliveira F Freitas LL | 2006 | Am J Ophthalmo12006，141，5： | 1 |
| 20 | Postoperative wavefront analysis and contrast sensitivity of a multifocal apodized diffractive IOL ( ReSTOR ) and three monofocal IOLs 显示文摘 | Rocha KM Chalita MR Souza CE Soriano ES Freitas LL Muccioli C | 2005 | J Refract Surg2005，21，6： | 1 |
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