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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Some chemical and toxicological aspects about paper mill effluent treatment with ozone显示文摘 | Freire R S Kunz A Duran N | 2000 | Environmental Technology2000，21，： | 1 |
| 3 | Effects of Fungal Laccase Immobilization Procedures for the Development of a Biosensor for Phenol Compounds显示文摘 | Renato S Freire Nelson Dura′n Lauro T | 2001 | Talanta2001，，54： | 1 |
| 4 | Zn-Ni Alloy Deposits Obtained by Continuous and Pulsed Electrodeposition Processes显示文摘 | PAGOTTO JR S O DE ALVARENGA FREIRE C M BALLESTER M | 1999 | Surface and Coatings Technology1999，122，： | 1 |
| 5 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 6 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 7 | Antimicrobial effecl of linalool and a -terpineol against periodontopathic and cariogenic bacteria显示文摘 | Park S N Lira Y K Freire M O | 2012 | Anaerobe2012，18，： | 1 |
| 8 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 9 | The essential oil of Eucalyptus tereticornis, and its constituents alpha-and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea 显示文摘 | Lima F J Brito T S Freire W B | 2010 | Fitoterapia2010，81，6： | 1 |
| 10 | Effects of EDTA on signal stability during electrochemi- cal detection of acetaminophen 显示文摘 | DECARVALHO R M FREIRE R S RATH S | 2004 | J Pharm Biomed Anal2004，34，5： | 1 |
| 11 | DNA vaccine against the non-structural 1 protein ( NS1 ) of dengue 2 virus显示文摘 | Costa S M Freire M S Alves A M | 2006 | Vaccine2006，24，： | 1 |
| 12 | Photoassisted electrochemical degradation of organic pollutants on a DSA type oxide electrode:Process test for a phenol synthetic so- lution and its application for the E1 bleach Kraft mill efflu- ent 显示文摘 | Pelegrini R T Freire R S Duran N | 2001 | Environmental Science & Technology2001，35，13： | 1 |
| 13 | Fungal laccase: copper induction, semi-purification, immobilization, phenolic effluent treatment and electrochemical measurement显示文摘 | CORDI L MINUSSI R C FREIRE R S | 2010 | Aft J Bioteehnol2010，6，10： | 1 |
| 14 | Studies on the electrochemical behavior of a eystine self-assembled monolayer modified electrode using ferro- cyanide as a probe 显示文摘 | Valber A Pedrosa Thiago R L C Paixlio Renato S Freire | 2007 | J Electroanal Chem2007，602，2： | 1 |
| 15 | Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J | 2007 | Chest2007，131，4： | 1 |
| 16 | Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria显示文摘 | PARK S N LIM Y K FREIRE M O | | 0，，： | 1 |
| 17 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers and Struc- tures2006，，84： | 1 |
| 18 | Early surgery for ruptured cerebral aneurysms: technical note显示文摘 | Sillero R O Sillero Filho V J Freire S B | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
| 19 | Structural assessment of minor axis steel joints using photoelasticity and finite elements 显示文摘 | Lima L R O Freire J L F Vellasco P C G S | 2009 | Journal of Constructional Steel Research2009，65，2： | 1 |
| 20 | Geo- metrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cable-stayed Bridges显示文摘 | FREIRE A M S NEGRAO J H O LOPES A V | 2006 | Com puters and Structures2006，84，3132： | 1 |
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