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| 1 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states显示文摘 | Schmid A W Freir D B Herron C E | 2008 | Brain research2008，1197，： | 1 |
| 4 | Panic disorder and social anxiety disorder subtypes in a caffeine challenge test显示文摘 | Nardi A E Lopes F L Freire R C | | 0，，02： | 1 |
| 5 | Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J | 2007 | Chest2007，131，4： | 1 |
| 6 | Evidence for Strict in Patient Blood Glucose Control Time to Revise Goals in Hospitalized Patients显示文摘 | Kitabchi A E Freire A X Umpierrez G E | 2008 | Metabolism2008，57，1： | 1 |
| 7 | Isochronicity via normal form 显示文摘 | Algaba A Freire E Gamero E | 2000 | Qual Theory Dyn Syst2000，1，2： | 1 |
| 8 | Film growth and relationship between microstructure and mechanical properties of a-C: H: F films deposited by PECVD显示文摘 | Maia da Costa M E H Jacobsohn L G | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 9 | Applications and Market of PVC for Piping Industry显示文摘 | Martins J D Freire E Hemadipour H | | 0，，01： | 1 |
| 10 | Methylprednisolone infusion in early severe ARDS:results of a randomized controlled trial显示文摘 | MEDURI G U GOLDEN E FREIRE A X | 2007 | Chest2007，131，4： | 1 |
| 11 | CD4 mimetics sensitize HIV-l-infected cells to ADCC 显示文摘 | Richard J Veillette M Brassard N Iyer SS Roger M Martin L Pazgier M Schon A Freire E Routy JP SmithAB 3rd Park J Jones DM Courter JR Melillo BN Kaufmann DE Hahn BH Permar SR Haynes BF MadaniN Sodroski JG Finzi A | 2015 | Proc Natl Acad Sci USA2015，112，20： | 1 |
| 12 | Ionic regulation and Na^+/-K^+ -ATPase activity in gills and kidney of the Antarctic aglomerular cod icefish exposed to dilute sea water显示文摘 | Romao S Freire C A Fanta E | 2001 | J Fish Biol2001，59，2： | 1 |
| 13 | Anti-neutrophil cytoplastic antibodies in the clinical forms of leprosy显示文摘 | Freire BF Ferraz AA Nakayama E | 1998 | Int J Lepr Other Mycobact Dis1998，66，4： | 1 |
| 14 | Methylprednisolone infusion in early severe ARDS : results of a randomized controlled trial 显示文摘 | Meduri GU Golden E Freire AX | 2007 | Chest2007，131，4： | 1 |
| 15 | MethyIprednisol_one infusion in early severe ARDS : results of a randomized controlled trial 显示文摘 | Meduri GU Golden E Freire AX | 2007 | Chest2007，131，3： | 1 |
| 16 | Regulation of muscle hydration upon hypo-or hyper-osmotic shocks:Differences related to invasion of the freshwater habitat by decapod crustaceans显示文摘 | FREIRE C A SOUZA-BASTOS L R AMADO E M | 2013 | J Exp Zool A Ecol Genet Physiol2013，319，6： | 1 |
| 17 | Non-invasive ventilation in cardiogenic pulmonary edema in the emergency department 显示文摘 | Carvalho L Cameiro R Freire E | 2008 | Rev Port Cardiol2008，27，2： | 1 |
| 18 | Seroprevalence of Anaplasma marginale in cattle from Center-South Region ofParan6 State, Brazil by a competitive ELISA test with recombi- nant MSP5-PR1 protein 显示文摘 | Marana E R Dias J A Freire R L | 2009 | Rev Bras Parasitol Vet2009，18，1： | 1 |
| 19 | Methylprednisolone infusion in early severe ARDS:results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX | | 0，，： | 1 |
| 20 | Methylprednisolone infusion in early ARIYS: results of a randomized controlled trial显示文摘 | Medufi GU Golden E Freire AX | 2008 | Chest2008，131，4： | 1 |
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