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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states显示文摘 | Schmid A W Freir D B Herron C E | 2008 | Brain research2008，1197，： | 1 |
| 3 | Effect of Moxibustion at Acupoints Ren-12 (Zhongwan),St-25 (Tianshu),and St-36 (Zuzanli) in the Prevention of Gastric Lesions Induced by Indomethacin in Wistar Rats显示文摘 | Freire A O Sugai G C Blanco M M | | 0，，02： | 1 |
| 4 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 5 | Panic disorder and social anxiety disorder subtypes in a caffeine challenge test显示文摘 | Nardi A E Lopes F L Freire R C | | 0，，02： | 1 |
| 6 | Epithelial transport of magnesium in the kidney of fish显示文摘 | Beyenbach K W Freire C A Kinne R K | 1993 | Miner Electrolyte Metab1993，19，45： | 1 |
| 7 | Studies on the electrochemical behavior of a eystine self-assembled monolayer modified electrode using ferro- cyanide as a probe 显示文摘 | Valber A Pedrosa Thiago R L C Paixlio Renato S Freire | 2007 | J Electroanal Chem2007，602，2： | 1 |
| 8 | Study of the diffusion coefficients of diphenylbutadiene and triclosan into and within meat显示文摘 | Sanches Silva A Freire J M C Losada P P | 2010 | European Food Research and Technology2010，230，6： | 1 |
| 9 | Coffee flavour: an overview显示文摘 | Buffo R A Cardelli - Freire C | 2004 | Flavour and Fragrance Journal2004，19，2： | 1 |
| 10 | Direct electron transfer: an approach for electrochemical biosensors with higher selectivity and sensitivity显示文摘 | FREIRE R S PESSOA C A MELLO L D | 2003 | J Braz Chem Soc2003，14，2： | 1 |
| 11 | Ionic regulation and Na^+/-K^+ -ATPase activity in gills and kidney of the Antarctic aglomerular cod icefish exposed to dilute sea water显示文摘 | Romao S Freire C A Fanta E | 2001 | J Fish Biol2001，59，2： | 1 |
| 12 | Anti-allergic effect of bee poleen phenolic extract and myricetin in ovalbumin-sensi- tized mice显示文摘 | Medeiros K C Figueiredo C A Freire K R | 2008 | Journal of ethnopharmacology2008，119，1： | 1 |
| 13 | Estabilidade Fisico-qutmica,Mierobiol6giea E Sensorial De Came Ovina Embalada a Vaeuo Estocada Sob Refrigeraqao 显示文摘 | FERNANDES R P P FREIRE M T A GUERRA C C G | 2012 | Ciencia Rural Santa Maria2012，42，4： | 1 |
| 14 | Neurobehavioral effect ofessential oil of Cymbopogon cUratus in mice 显示文摘 | Blanco M M Costa C Freire A 0 | 2009 | Phytomedicine2009，16，23： | 1 |
| 15 | Al-basod anodicoxide films structure observation using field emission gun scanning electron microscopy 显示文摘 | Regone N N Freire C M A Batlestcr M | 2006 | JoBrBal of Materials Process-ing Technology2006，172，： | 1 |
| 16 | Regulation of muscle hydration upon hypo-or hyper-osmotic shocks:Differences related to invasion of the freshwater habitat by decapod crustaceans显示文摘 | FREIRE C A SOUZA-BASTOS L R AMADO E M | 2013 | J Exp Zool A Ecol Genet Physiol2013，319，6： | 1 |
| 17 | Experimental techniques in the field of pipeline integrity显示文摘 | Freire J L F Vieira R D Benjamin A C | 2003 | Experimental Techniques2003，，5： | 1 |
| 18 | Epithelial transport of magnesium in the kidney of fish显示文摘 | Beyenbach K W Freire C A Kinne R K H | 1993 | Mineral and Electrolyte Metabolism1993，19，45： | 1 |
| 19 | Miscanthus×giganteus extractives:A source of valuable phenolic compounds and sterols显示文摘 | Villaverde J J Domingues R M A Freire C S R | 2009 | Journal of Agricultural and Food Chemistry2009，57，9： | 1 |
| 20 | Burst tests of pipeline with extensive longitudinal metal loss显示文摘 | Freire J L F Vieira R D Benjamin A C | 2006 | ExperimentalTechniques2006，，11： | 1 |
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