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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Interferon-gamma and lipopolysaccharide potentiate monocyte tissue factor induction by C-reactive protein:relationship with age,sex and hormone replacement treatment 显示文摘 | NAKAGOMI A FREEDMAN S B GECZY C L | 2000 | Circulation2000，101，15： | 2 |
| 3 | p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells显示文摘 | Bromleigh V C Freedman L P | 2000 | Genes Dev2000，14，20： | 1 |
| 4 | Models quantify the total maximum daily load process 显示文摘 | DePinto J V Paul L Freedman P E | 2004 | Journal of Environmental Engineering2004，130，6： | 1 |
| 5 | Bilateral differences in the human occipital EEG with unilateral photic driving显示文摘 | Freedman N L | 1963 | Science1963，142，3592： | 1 |
| 6 | Damage con- trol surgery for spine trauma显示文摘 | Kossmann T Trease L Freedman I | 2004 | Injury2004，35，7： | 1 |
| 7 | Abnormal sleep/ wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit显示文摘 | Freedman NS Gazendam J Levan L | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 8 | Disorder- enhanced transport in photonic quasicrystals 显示文摘 | Levi L Rechtsman M Freedman B | 2011 | Science2011，332，637： | 1 |
| 9 | Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia显示文摘 | MARTIN L F KEM W R FREEDMAN R | 2004 | Psychopharmacology2004，174，： | 1 |
| 10 | Variables affecting the yields offatty eters from transesterified vegetable oils 显示文摘 | Freedman B Pryde E H Miybts T L | 1984 | JAOCS1984，61，： | 1 |
| 11 | The cvidcncc for obstetric care 显示文摘 | Paxton A Maine D Freedman L et aJ | 2005 | Int J Gynaecol Obstet2005，88，2： | 1 |
| 12 | Toxic effects of lead on neuronal development and funetion显示文摘 | Freedman R Olson L Hoffer B J | 1990 | Environ Health Persp1990，89，： | 1 |
| 13 | Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro,but is not more virulent than other clinical isolates显示文摘 | Manca C Tsenova L Barry CE 3rd Bergtold A Freeman S Haslett PA Musser JM Freedman VH Kaplan G | 1999 | J Immunol1999，162，11： | 1 |
| 14 | Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer 显示文摘 | Burke L Khan MA Freedman AN | 1998 | Cancer Res1998，58，12： | 1 |
| 15 | Variables affecting the yields of fatty esters from transesterified vegetable oils显示文摘 | FREEDMAN B PRYDE C H MOUNTS T L | 1984 | J Am Oil Chem Soc1984，61，： | 1 |
| 16 | Improved consideration of the margin of safety in total maximum daily load development显示文摘 | Dilks D W Freedman P L | 2004 | Journal of Environmental Engineering2004，130，6： | 1 |
| 17 | Variables affecting the yields of fatty esters from transesterified vegetable oils显示文摘 | Freedman B Pryde E H Mounts T L | 1984 | Journal of the American OilChemists Society1984，61，10： | 1 |
| 18 | Allelic deletion analysis of the FHIT gene predicts poor survival in non - small cell lung cancer显示文摘 | BURKE L KHAN M A FREEDMAN A N | 1998 | Cancer Res1998，58，6： | 1 |
| 19 | Near-infrared and mid-infrared Fourier transform vibrational circular dichroism of proteins in aqueous solution 显示文摘 | Ma S Freedman T B Dukor R K Nafie L A | 2010 | Appl Spectrosc2010，64，6： | 1 |
| 20 | Inter-relationships among childhood BMI, childhood height, and adult obesity : the Bogalusa Heart Study 显示文摘 | FREEDMAN D S KHAN L K SERDULA M K | 2004 | Int J Obes Relat Metab Disord2004，28，1： | 1 |
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