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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 4 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 5 | Lymphocyte subsets in peripheral blood of dogs a flow cytometrie study 显示文摘 | MARTIN F LENKA L | 2001 | Vet Immunol Immunopathlo2001，83，： | 1 |
| 6 | CuInSe2thin films grown by MOCVD: characterization, first devices 显示文摘 | Artaud M C Ouchen F Martin L | 1998 | Thin solid films1998，324，： | 1 |
| 7 | CuInSe2 thin films grown by MOCVD= Characterization, {irst devices 显示文摘 | Artaud M C Ouchen F Martin L | 1998 | Thin solid films1998，324，： | 1 |
| 8 | Effects of salt andtemperature on proteolysis during ripening of Iberian ham 显示文摘 | Martin L C6rdoba J J Antequera T f | 1998 | Meat Science1998，49，： | 1 |
| 9 | Theoretical Comparison Between Different Configurations of Radial and Conventional Bogies 显示文摘 | GARCIA J F OLAIZOLA X MARTIN L M GIMENEZ J G | 2000 | Vehicle System Dynamics2000，，33： | 1 |
| 10 | Agro- industrial residues as low-price feedstock for diesel- like fuel production by thermal cracking显示文摘 | Santos A L F Martins D U Iha O K | 2010 | Bioresource Technology2010，101，： | 1 |
| 11 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 12 | Conduction at Domain Walls in Oxide Multiferroics 显示文摘 | Seidel J Martin L W Scott J F | 2009 | Nature Mater2009，8，： | 1 |
| 13 | Leaching of Cd, Zn, Pb and Cu in packed and undisturbed columns of soils affected by the spill from a pyrited mine in the south of Spain 显示文摘 | Sanchez- martin M J Lorenzo L F Sanchez- Camazano M | 2001 | Soil and Sediment Contamination2001，10，： | 1 |
| 14 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 15 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats 显示文摘 | Andersen M L Martins P G F D'Almeida V | 2004 | Exp Gerontol2004，39，6： | 1 |
| 16 | Multistage expansion planning for active distribution networks under demand and distributed generation uncertainties显示文摘 | BORGES C L T MARTINS V F | 2012 | International Journal of Electrical Power Energy Systems2012，36，1： | 1 |
| 17 | The effects of selected probiotic strains on he development of eczema ( the Panda study) 显示文摘 | Niers L Martin R Rijkers G Sengers F Timmerman H van Uden N | 2009 | Allergy2009，64，9： | 1 |
| 18 | Isoflurane,but not halothane,depresses c-Fos expression in rat spinal cord at concentrations that suppress reflex movement after supramaximal noxious stimulation显示文摘 | Jinks S L Antognini J F Martin J T | 2002 | Anesth Analg2002，95，： | 1 |
| 19 | Human embryonic stem cells:prospects for development显示文摘 | Martin F Pera L Alan O | 2004 | Development2004，18，： | 1 |
| 20 | Formation of Strecker aldehydes and pyrazines in a fried potato model system显示文摘 | Martin F L Ames J A | 2001 | J Agri Food Chem2001，49，8： | 1 |
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