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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | The Kozak sequence polymorphism of platelet glycoprotein Ibα and risk of nonfatal myocardial infarction and nonfatal stroke in young women显示文摘 | Frank MB Reiner AP Schwartz SM | 2001 | Blood2001，97，4： | 1 |
| 3 | Polymorphisms of coag- ulation factor ⅩⅢ subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，： | 1 |
| 4 | Polymorphisms of coagula- tion factor ⅩⅢ subunit A and risk of nonfatal hemorrhagic stroke in young white women 显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 5 | Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 6 | Polymorphisms ofcoagulation factorX III subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 7 | Finite element modeling approaches of human cervical spine facet joint capsule 显示文摘 | Srirangam K Narayan Y Frank AP | 1998 | J Biomech1998，31，： | 1 |
| 8 | Primary intrasellar germinoma:case report显示文摘 | Frank G Galassi E Fabrizi AP | | 0，，： | 1 |
| 9 | ERc: upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue 显示文摘 | Kim M Neinast MD Frank AP | 2014 | Mol Metab2014，3，6： | 1 |
| 10 | Near-field optical analysis of living cells in vitro显示文摘 | SOMMER AP FRANKE RP | 2002 | J Proteome Res2002，1，2： | 1 |
| 11 | Polymorphisms of coagulation factor ⅩⅢ subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 12 | Quantitative analysis of the morphology of secundum-type atrial septal defects and their dynamic change using transesophageal three-dimensional echocardiography显示文摘 | Kuhl HP Rulands D | 1997 | Circulation1997，96，9： | 1 |
| 13 | Polymorphisms of coagulation factor ⅩⅢ subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 14 | Achievement goals theory and disor- dered eating: relationships of disordered eating with goal orienta- tions and motivational climate in female gymnasts and dancers 显示文摘 | Karin AP Frank C Raul RD | 2009 | Psychol Sport Exerc2009，10，1： | 1 |
| 15 | Coagulation factor ⅩⅢ polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women显示文摘 | Reiner AP Frank MB Schwartz SM | 2002 | Br J Haematol2002，116，2： | 1 |
| 16 | PI3 kinases and PTEN:how opposites chemoattract显示文摘 | Frank IC Carole AP | 2002 | Cell2002，109，5： | 1 |
| 17 | Combined inhibition of the BMP pathway and the RANK-RANKL axis in a mixed lytic/blastic prostate cancer lesion显示文摘 | MANDEEP SV FARHANG A FRANK AP | 2011 | Bone2011，48，2011： | 1 |
| 18 | Dose higher hospital cost imply higher quality of care显示文摘 | Gabriel AP Frank AS Chou SY | 2003 | Rev Econ Star2003，，1： | 1 |
| 19 | Polymorhpisms of coagulation (ⅫⅠ) factor subunit A and risk of nonfatal hemorrhagic stroke in young white women显示文摘 | Reiner AP Schwartz SM Frank MB | 2001 | Stroke2001，32，11： | 1 |
| 20 | How competitive is the‘pioneer-climax’tree species Nothofagus alpina in pristine temperate forests of Chile?显示文摘Aims Nothofagus species are constitutive elements of the temperate forests along the Southern Andes Mountains.The deciduous Nothofagus alpina is a fast-growing,but long-lived opportunistic pioneer spe-cies(‘pioneer-climax species’)and co-occurs with the evergreen N.dombeyi.We tested whether N.alpina is competitively superior to N.dombeyi in mature stands and whether intra-specific competition in N.alpina is stronger than inter-specific competition with N.dombeyi.Methods In a pristine old-growth forest in South-Central Chile,we compared the growth of N.alpina trees in pure stands and in mixture with N.dombeyi to the growth of N.dombeyi and calculated compe-tition indices.We related growth variables to climate data and weather extremes.Important Findings In N.alpina,juvenile basal area increment was signifi-cantly higher in pure than in mixed stands.Contrary to our hypothesis,N.dombeyi exhibited larger radial stem increments than N.alpina in the most recent 40 years.In the most recent two decades,this was caused by high growth rates of large N.dombeyi trees.In both Nothofagus species,stem growth was negatively related to temperature,but N.dombeyi responded more sensitively to weather conditions than N.alpina.In N.alpina,stem increment was negatively related to the intensity of competition,but the size of the competition effects on this species was similar in pure and mixed stands.Thus,compared to N.alpina,the‘pioneer-climax species’concept is even more appropriate for N.dombeyi with its relatively high growth rates even in the early stages of its life. | Rebekka Bögelein Cecilia APérez Philipp Schäferand Frank M.Thomas | 2019 | Journal of Plant Ecology2019，12，1： | 0 |
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