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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 3 | Modelling tem-pering behaviour of dark chocolates from varying particle size distribu-tion and fat content using response surface methodology显示文摘 | AFOAKWA E O PATERSON A FOWLER M | 2008 | Innovative Food Science and Emerging Technologies2008，9，4： | 1 |
| 4 | Electronic properties of two-dimensional systems 显示文摘 | Ando T Fowler A B Stern F | 1982 | Rev Mod Phys1982，54，2： | 1 |
| 5 | Current concepts of sepsis acute lung injury显示文摘 | SESSLERC N BLOOMFIELD G L FOWLER A A | 1996 | Clin Chest Med1996，17，2： | 1 |
| 6 | A hybrid approach using the analytic hierarchy process and integer programming to screen weapon systems projects 显示文摘 | Greiner M A Fowler J W Shunk D L | 2003 | IEEE Transactions on Engineering Management2003，50，2： | 1 |
| 7 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 8 | Assessment ofovarian reserve-should we perform tests of ovarian reserveroutinely? 显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，： | 1 |
| 9 | Prevalence of chronic disabling fatigue in children and adolescents 显示文摘 | Farmer A Fowler T Scourfield J | 2004 | BrJ Psychiatry2004，，184： | 1 |
| 10 | An evaluation ofthe national safety council,s defensive driving course invarious states 显示文摘 | Planek T W Schupack S A Fowler R C | 1974 | Accident Analysis & Prevention1974，6，34： | 1 |
| 11 | GIGANTEA,A Circadian Clock-controlled Gene that Regulates Photo- periodic Flowering in Arabidopsis and Encodes a Protein with Several Possible Membrane-spanning Domains显示文摘 | FOWLER S ONOUCHI H SANACH A | 1999 | EMBO J1999，18，： | 1 |
| 12 | US for detecting renal calculi with nonenhanced CT as a reference standard 显示文摘 | Fowler K A B Locken J A Duchesne J H | 2002 | Radiology2002，222，1： | 1 |
| 13 | Enrich-ment of microsatellite from the citrus genome using bi-otinylated oligonucleotide sequence bound to strepta-vidin-coated magnetic particles显示文摘 | KIJAS J M FOWLER J C GARBETT C A | 1994 | Biotechniques1994，16，4： | 1 |
| 14 | Leaching of zinc sulfide by Thiobacillus ferrooxidans: Bacterial oxidation of the sulfur product layer increases the rate of zinc sulfide dissolution at high concentrations of ferrous ions显示文摘 | FOWLER T A CRUNDWELL F K | 1999 | Applied and Environme- ntal Microbiology1999，65，12： | 1 |
| 15 | Imaging Techniques for the Assessment of Body Composition 显示文摘 | Fuller M F Fowler P A McNeil1 G | 1994 | Nutr1994，124，： | 1 |
| 16 | Beyond products: New strategic imperatives for developing competencies in dynamic environments显示文摘 | Fowler S W King A W Marsh S J | 2000 | Journal of Engineering and Technology Management2000，17，34： | 1 |
| 17 | Paliperidone extended release tablets for the acute and maintenance treatment of schizophrenia 显示文摘 | Fowler J A Bettinger T L Argo T R | 2008 | ClinTher2008，30，2： | 1 |
| 18 | Assessment of ovarian reserve--should we perform tests of ovarian reserve routinely?显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，11： | 1 |
| 19 | Assessment of ovarian reserve-should we perform tests of ovarian reserve routinely? 显示文摘 | Maheshwari A Fowler P Bhattacharya S | 2006 | Hum Reprod2006，21，： | 1 |
| 20 | The Optimal Spacing Between Horizontal Cylinders in a Fixed Volume Cooled by Natural Convection 显示文摘 | Bejan A Fowler A J Stanescu G | 1995 | International Journal of Heat and Mass Transfer1995，38，11： | 1 |
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