|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Acid tolerance mediated by membrane ATPases in Lactobacillus acidophilus 显示文摘 | Lorca G L Valdez G Font | 2001 | Biotechnology Letters2001，23，： | 1 |
| 3 | Effect of Fatty Acid Addition on the Properties of Biopolymer Films Based on Lipophilic Maize Starch and Gelatin 显示文摘 | F M FAKHOURI L C B FONTES L H INNOCENTINI- MEI | 2009 | Starch-Starke2009，，61： | 1 |
| 4 | Competitive adsorption of zinc,cadmium,copper and lead in three highly weathered Brazilian soils显示文摘 | Fontes M P F Matos A F Costa L M | 2000 | Commun Soil Sci Plant Anal2000，31，： | 1 |
| 5 | Heart -rate variability and precompetitive anxiety in swimmers 显示文摘 | Cervantes Blasquez J C Rodas Font G Capdevila Ortis L | 2009 | Psicothema2009，21，4： | 1 |
| 6 | Selectivity sequence and competitive adsorption of heavy metals by Brazilian soils显示文摘 | Gomes P C Fontes M P F Costa L M | 2001 | Soil Sci Soc Am J2001，65，： | 1 |
| 7 | Variations in melt pro- ductivity and melting conditions along SWIR (70:E 49:E): Evidence from olivine-hosted and plagioclase-hosted melt in- clusions显示文摘 | Font L Murton B Roberts S | 2007 | Journal of Petrology2007，48，14： | 1 |
| 8 | Influence of growth temperature on cryotolerance and lipid composition of lactobacillus acidophilus显示文摘 | FERNANDEZ MURGA M L CABRERA G M FONT DE VALDEZ G | 2000 | Journal of Applied Microbiology2000，88，2： | 1 |
| 9 | Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus显示文摘 | Font J Pallares L Martorell J | | 0，，03： | 1 |
| 10 | 5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hy- pertrophy显示文摘 | Fontes M S Raaijmakers A J van Doorn T l Changes in Cx 43 and NaV 1 | 2014 | PLoSOne2014，9，87： | 1 |
| 11 | Growth and yield of potatoes in relation to method of application of Zn fertilizers and to fungicides containing Zn显示文摘 | Moreira M A Fontes P C R Fontes R L F Cardoso A A | 2000 | Horticultura Brasileira2000，18，1： | 1 |
| 12 | An Intelligent Tuto- ring Module Controlled by BDI Agents for an E- learning Platform 显示文摘 | Fonte F A M Burguillo J C Nistal M L | 2012 | Expert Systems with Applications2012，39，8： | 1 |
| 13 | Floor radiant system with heat storage by a solid-solid phase transition material 显示文摘 | Barrio M Font J Lopez D O Muntasell J Tamarit J L | 1992 | Solar Energy Material and Solar Cells1992，27，2： | 1 |
| 14 | Surface potential and longitudinal electric field measurements in the aerodynamic plasma actuator显示文摘 | Enloe C L Font G I McLaughlin T E | 2008 | AIAA Journal2008，46，11： | 1 |
| 15 | Relative value of the lumbar spine and hip bone mineral density and bone turnover markers in men with ankylosing spondylitis显示文摘 | Muntean L Rojas-Vargas M Font P | 2011 | Clin Rheumatol2011，30，： | 1 |
| 16 | Volunteer tourism,greenwashing and understanding responsible marketing using market signal- ling theory显示文摘 | Smith V L and Font X | 2014 | Journal of Sustainable Tourism2014，22，6： | 1 |
| 17 | Chronic infusion of an- giotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea 显示文摘 | da Silva A Q Fontes M A Kanagy N L | 2011 | Brain Res2011，1368，： | 1 |
| 18 | Anaerobic co- digestion of the organic fraction of municipal solid waste with FOG waste from a sewage treatment plant: Recovering a wasted methane potential and enhancing the biogas yield 显示文摘 | Martin-Gonzdlez L Cohurato L F Font X | 2010 | Waste Management2010，30，10： | 1 |
| 19 | Measuring Convergence of National Accounting Standards with International Financial Reporting Standards显示文摘 | Fontes A Rodrigues L Craig R | 2005 | Accounting Forum2005，29，4： | 1 |
| 20 | Measuring convergence of national accounting standards with International Financial Reporting Standards 显示文摘 | Fontes A L Rodfigues R Craig | 2005 | Accounting Foram2005，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员