| 1 | Antiinflammatory activity of the methanolic extract of the seeds of Carica papaya in experimental animals显示文摘Objective:To scientifically verify the claims of our traditional healers on the anti-inflammatory activity of Carica papaya(C.papaya) and possibly deduce its activities.Methods:0.1 mL of fresh egg albumin was injected into the right hind-paw of adult white Wistar rats to induce inflammation an hour post intraperitoneal(IP) administration of 50-200 mg/kg doses of the extract to 3 groups of 5 rats per group.The 4th group of 5 rats was used as negative control and received 2 mL/kg(IP) of physiological saline,while the 5th group of 5 rats was used as positive-comparative control and received(IP) 150 mg/kg of aspirin.Increases in diameter of the paw were measured with the aid of Veneer Calipers before extract administration and at interval of 30 minutes post administration for further 2 hours.Percentage inhibition of oedema was calculated for each dose group and results were subjected to statistical analysis using student /-test and analysis of variance(ANOVA).Results:All doses of extract showed a dose and time dependent inhibition effects of oedema(P<0.05).Conclusions:This work is at present though limited to animals,the anti-inflammatory activity of the seeds of C.papaya is perhaps proven. | Amazu LU Azikiwe CCA Njoku CJ Osuala FN Nwosu PJC Ajugwo AO Enye JC | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 2 |
| 2 | HIV/AIDS selective infectivity-report of two peculiar cases显示文摘We report two peculiar cases that were observed in two communities of Anambra State,South East Nigeria.The first case was a woman of 44 with a history of blood transfusion from a donor of questionable HIV status.A pint of blood was transfused in a private Hospital on the 15th January. 2000.She has had no form of antiviral therapy until 22nd April.2008 when she came to the hospital for routine medical check up.Her HIV result came out confirmed positive while that of her husband came out negative.She has had active sexual life with her husband in the previous eight years as they have had some difficulties in getting their desired extra two children having earlier gotten a boy and a girl.The second case involves a family of six.A couple with four children of ages about 6 months,2 years,3 years and 5 years.The youngest,a female presented with fever and multiple lymphadenopathy.She tested HIV positive and so was her mother and her second sibling.But her father and two other siblings remained negative at post three and six months intervals from their very first test date with us.These reported cases appear to go contrary to earher formed opinion on HIV transmission.We support the opinion on a naturally,occurring substance,APOBEC3G which possibly confers permanent immunity against the HIV virus.We recommend clinical trials of the characterized APOBEC3G as a vaccine for non HIV infected persons of all ages and to people living with HIV/AIDS as a therapeutic drug. | Azikiwe CCA Ifezulike CC Amazu LU Enye JC Nwosu PJC Osuala FN | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 0 |
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