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| 1 | Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects显示文摘In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal syndrome.Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.As a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors. | S?ren M?ller Jens H Henriksen Flemming Bendtsen | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | Axial force measurement for esophageal function testing显示文摘The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the 'golden standard' for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe with combined axial force and manometry recordings showed that axial force amplitude increased by 130% in contrast to an increase of 30% using manometry. Using axial force in combination with manometry provides a more complete picture of esophageal motility, and the current paper outlines the advantages of using this method. | Flemming H Gravesen Peter Funch-Jensen Hans Gregersen Asbjφrn Mohr Drewes | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 3 | Two-way coupled fluid structure interaction simulation of a propeller turbine显示文摘 | H Schmucker F Flemming S Coulson | 2010 | IOP Conference Series: Earth and Environmental Science2010，，1： | 2 |
| 4 | Application of fluorescenfly labelled lectins for the visualization and biochemical characterization of polysaccharides in biofilms of Pseudomonas aeruginosa 显示文摘 | STRATHMAN M WINGENDER J FLEMMING H C | 2002 | J Microbiol Meth2002，50，3： | 1 |
| 5 | The Permeability of Biofouling Layers on Membranes 显示文摘 | McDonogh R Schaule G Flemming H C | 1994 | J Membr Sci1994，87，： | 1 |
| 6 | The permeability of biofouling layers on membranes显示文摘 | McDonogh R Schaule G Flemming H C | 1994 | J Membr Sci1994，87，： | 1 |
| 7 | Biofouling on membrane a microbiological approach 显示文摘 | Flemming H C | 1988 | Desalination1988，70，1： | 1 |
| 8 | The biofilm matrix 显示文摘 | Flemming H C Wingender J | 2010 | Nature Reviews Microbiology2010，8，9： | 1 |
| 9 | The biofilm ma- trix显示文摘 | FLEMMING H C WINGENDER J | 2010 | Nature Reviews Microbiology2010，8，9： | 1 |
| 10 | Relevance of Microbial Extracellular Polymeric Substances (EPSs)-Part I:Structural and Ecological Aspects显示文摘 | FLEMMING H C WINGENDER J | 2001 | Water Science and Technology2001，143，6： | 1 |
| 11 | Application of fluorescently labelled lectins for the visualization and biochemical characterization of polysaccharides in biofilms of Pseudomonas aeruginosa显示文摘 | Strathmann M Wingender J Flemming H C | 2002 | J Microbiol Methods2002，50，3： | 1 |
| 12 | Relevance of microbial extracellular polymeric substances (EPSs) - Part I: structural and ecological aspects 显示文摘 | Flemming H C Wingender J | 2001 | Water Sci Tech2001，43，6： | 1 |
| 13 | Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma显示文摘 | Hogemann D Flemming P Kreipe H | 2001 | Eur Radio2001，11，1： | 1 |
| 14 | Serum concentrations of antibodies against vaccine toxoids in children显示文摘 | CARSTEN H ESBEN B J FLEMMING N | | 0，，10： | 1 |
| 15 | Differential clinical treatment outcome after systemic metronidazole and amxicillin in patients harboring显示文摘 | Flemming TF Milian E Karch H | 1998 | J Clinical Peridontology1998，25，4： | 1 |
| 16 | Present Sta- tus of Aeroelasticity of Wind Turbines 显示文摘 | Flemming R Morten H H Kenneth T | 2003 | Wind Energy2003，6，： | 1 |
| 17 | The biofilm matrix显示文摘 | Flemming H C Wingender J | | 0，，： | 1 |
| 18 | Biofouting in water systems cases, causes and 显示文摘 | Flemming H C | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
| 19 | Controlled unsteady state processes and technologies-an overview显示文摘 | Irvine R L Wilderer P A Flemming H C | 1997 | Water Sci Technol1997，35，1： | 1 |
| 20 | The biofilm matrix 显示文摘 | Flemming H C Wingender J | 2010 | Nat R ev Microbiol2010，8，9： | 1 |
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