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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Caffeic acid phenethyl ester,an inhibitor of nuclear factor-kappaB,attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats显示文摘 | Wang J Le T | 2001 | J-Pharmacol-Exp-Ther2001，299，3： | 1 |
| 4 | Green chemistry: science and politics of change 显示文摘 | Poliakoff M Fitzpatrick J M Farren T R Anastas P T | 2002 | Science2002，297，： | 1 |
| 5 | Detailed study of attached and separated compression corner flowfields in high Reynolds number supersonic flow 显示文摘 | Settles G S Fitzpatrick T J Bogdonoff S M | 1979 | A IAA Journal1979，17，6： | 1 |
| 6 | Green chemistry Science and politics of change 显示文摘 | Poliakoff M Fitzpatrick J M Farren T P | 2002 | Science2002，297，： | 1 |
| 7 | Green chemistry: science and politics of change显示文摘 | POLIAKOFF M FITZPATRICK J M FARREN T R | 2002 | Science2002，297，： | 1 |
| 8 | Green chemistry: science and pohtics of change 显示文摘 | Poliakoff M Fitzpatrick J M Fatten T R | 2002 | Science2002，297，： | 1 |
| 9 | Effect of standardized orders and provider education on head - of bed positioning in mechanically ventilated patients 显示文摘 | HELMAN D L Jr SHERNER J H 3rd FITZPATRICK T M | 2003 | Crit Care Med2003，31，9： | 1 |
| 10 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle 显示文摘 | Fitzpatrick D C Otto J K Mckinlry T O | 2011 | J Orthop Trauma2011，18，5： | 1 |
| 11 | Effect of standardized orders and provider education on head-of-bed positioning in mechanically ventilated patients显示文摘 | HELMAN D L SHERNER J H 3rd FITZPATRICK T M | 2003 | Crit Care Med2003，31，9： | 1 |
| 12 | Green chemistry: science and politics of change显示文摘 | Poliakoff M Fitzpatrick J M Farren T R | 2002 | Science2002，297，： | 1 |
| 13 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle显示文摘 | FITZPATRICK D C OTTO J K MCKINLEY T O | 2004 | J Orthop Trauma2004，18，： | 1 |
| 14 | Green Chemistry Science and Politics of Change显示文摘 | Poliakoft M Fitzpatrick J M Farren T R | | 0，，5582： | 1 |
| 15 | Green chemistry:science and politics of change显示文摘 | Poliakoff M Fitzpatrick J M Farren T R | 2002 | Science2002，297，： | 1 |
| 16 | Vitamin deficiencies in humans: can plant science help显示文摘 | Fitzpatrick T B Basset G J Borel P | 2012 | The Plant Ce112012，24，2： | 1 |
| 17 | Detailed Study of Attached and Separated Compression Corner Flowfields in High Reynolds Number Supersonic Flow显示文摘 | Settles G S Fitzpatrick T J Bogdonoff S M | 1979 | AIAA Jour- nal1979，17，6： | 1 |
| 18 | Atomic structure and hierarchical assembly of a cross-beta amyloid fibril显示文摘 | FITZPATRICK A W P DEBELOUCHINA G T BAYRO M J | 2013 | Proc Natl Acad Sci USA2013，110，14： | 1 |
| 19 | Heat shock proteins: their role in urological tumors显示文摘 | Lebret T Watson R W Fitzpatrick J M | 2003 | J Urol2003，169，1： | 1 |
| 20 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle显示文摘 | Fitzpatrick D C Otto J K Mc Kinley T O | 2004 | J Orthop Trauma2004，18，5： | 1 |
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