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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Testing of biological aerated filter (BAF) media 显示文摘 | Kent T D Fitzpatrick C S B Williams S C | 1996 | Wat Sci Tech1996，34，34： | 2 |
| 4 | Caffeic acid phenethyl ester,an inhibitor of nuclear factor-kappaB,attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats显示文摘 | Wang J Le T | 2001 | J-Pharmacol-Exp-Ther2001，299，3： | 1 |
| 5 | Physiological and eco- logical correlates of preferred temperature in fish显示文摘 | BEITINGER T L FITZPATRICK L C | 1979 | Ameri- can Zoologist1979，19，1： | 1 |
| 6 | Supporting public availability and accessibility with elvin:experiences and reflections显示文摘 | FITZPATRICK G KAPLAN S MANSFIELD T | 2002 | Computer Supported Cooperative Work2002，11，3： | 1 |
| 7 | Green chemistry: science and politics of change 显示文摘 | Poliakoff M Fitzpatrick J M Farren T R Anastas P T | 2002 | Science2002，297，： | 1 |
| 8 | The Millennium BridgeLondon: problem and solutions 显示文摘 | Dallard P Fitzpatrick T Hidsill-Smith | 2001 | The Structural Engineer2001，79，8： | 1 |
| 9 | Detailed study of attached and separated compression corner flowfields in high Reynolds number supersonic flow 显示文摘 | Settles G S Fitzpatrick T J Bogdonoff S M | 1979 | A IAA Journal1979，17，6： | 1 |
| 10 | Medullar endocrine and genetic mecha- nism of arterial calcification显示文摘 | DOHERTY T M FITZPATRICK L A INOUE D | 2004 | Endocr Rev2004，25，4： | 1 |
| 11 | Testing of biological aerated filter (BAF) media显示文摘 | Kent T D Fitzpatrick C S B William S C | 1996 | Water Sci Technol1996，34，34： | 1 |
| 12 | Supporting public availability and accessibility with Elvin : Experiences and reflections 显示文摘 | FITZPATRICK G KAPLAN S MANSFIELD T DAVID A SEGALL B | 2002 | Computer Supported Cooperative Work2002，11，3： | 1 |
| 13 | Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor显示文摘 | COVEY T M EDES K FITZPATRICK F A | 2007 | Oncogen2007，26，39： | 1 |
| 14 | Charac- terization of YqjM, an old yellow enzyme hom01og from Bacillus subtilis involved in the oxidative stress response显示文摘 | FITZPATRICK T B AMRHEIN N MACHEROUX P | 2003 | Journal of biological chemistry2003，278，19： | 1 |
| 15 | Exploring the effects of urban and agricultural land use on surface water chemistry,across a regional atershed, using multivariate statistics显示文摘 | FITZPATRICK M L LONG D T PIJANOWSKI B C | 2007 | AppliedGeochemistry2007，22，8： | 1 |
| 16 | Green chemistry Science and politics of change 显示文摘 | Poliakoff M Fitzpatrick J M Farren T P | 2002 | Science2002，297，： | 1 |
| 17 | Characterization of YqjM,an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response 显示文摘 | Fitzpatrick T Amrhein N Macheroux P | 2003 | J Biol Chem2003，278，19： | 1 |
| 18 | Green chemistry: science and politics of change显示文摘 | POLIAKOFF M FITZPATRICK J M FARREN T R | 2002 | Science2002，297，： | 1 |
| 19 | Green chemistry: science and pohtics of change 显示文摘 | Poliakoff M Fitzpatrick J M Fatten T R | 2002 | Science2002，297，： | 1 |
| 20 | Habits and rabbits:Word associations and the L2 lexicon显示文摘 | Fitzpatrick T | 2006 | EUROSLA Yearbook2006，6，： | 1 |
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