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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Convergent and discriminant validation by the muhitrait- multimethod matrix 显示文摘 | Campbell D T Fiske D W | 1959 | Psychological Bulletin1959，56，： | 1 |
| 3 | Diagnostic and therapeutic transabdominal amnioinfusion in oligohydramnios 显示文摘 | Fisk NM Ronderos Dumit D Soliani A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 4 | Large subway systems as complex networks 显示文摘 | Angeloudis P Fisk D | 2006 | Physica A: Statistical Mechanics and Its Applications2006，367，5： | 1 |
| 5 | Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates显示文摘 | Deb N Chakravarti Michael J Fiske Leah D Fletcher Robert J Zagursky | 2001 | Vaccine2001，，6： | 1 |
| 6 | Sustainable development and post-occupancy evaluation 显示文摘 | FISK D | 2001 | Building Res & Inl2001，29，6： | 1 |
| 7 | Large subway systems as complex net- works显示文摘 | Angeloudis P Fisk D | 2006 | Physic A2006，367，： | 1 |
| 8 | Large subway systems as complex networks显示文摘 | Angeloudis P Fisk D | 2006 | Physica A2006，367，2： | 1 |
| 9 | Neuropsychological predic- tors of incident dementia in patients with vascular cognitive im- pairment, without dementia显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 10 | Convergent and Discriminant Validation by the Muhitrait-Multimethod Matrix 显示文摘 | Campbell D T Fiske D W | 1959 | Psychological Bulletion1959，56，： | 1 |
| 11 | Preclinical vascular cognitive impairment and Alzheimer disease:neuropsychological test performance 5 years before diagnosis显示文摘 | INGLES J L BOULTON D C FISK J D | | 0，，04： | 1 |
| 12 | ACCEL: Automated circuit card etching layout 显示文摘 | Fisk C J Caskey D L West L E | 1967 | Proceedings of the IEEE1967，55，11： | 1 |
| 13 | Consistency of the factorial structures of personality ratings from different sources 显示文摘 | Fiske D W | 1949 | Journal of Abnormal and Social Psychology1949，44，3： | 1 |
| 14 | Diagnostic and therapeutic transabdominal amnioinfusion in oligohydramnios 显示文摘 | FISK NM RONDEROS-DUMIT D SOLIANI A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 15 | Large subway systems as complex net- works显示文摘 | Angeloudis P Fisk D | 2006 | Physica A2006，367，： | 1 |
| 16 | Diagnostic and therapeutic transabdominal amnioinfusion in oligohydramnios显示文摘 | Fisk NM Ronderos Dumit D Soliani A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 17 | A molecular cloning of the maize gene crp1 reveals similarity between regulators of mitochondrial and chloroplast gene expression显示文摘 | Fisk D G Walker M B | 1999 | The EMBO Journal1999，18，： | 1 |
| 18 | Diagnostic and therapeutic transabdominal amnioinfusion in oligohydramnios显示文摘 | Fisk NM Ronderos-Dumit D Soliani A | 1991 | Obstet Gynecol1991，78，： | 1 |
| 19 | Establishing luminescence methods to detect irradiated foods显示文摘 | Sanderson D C W Carmichael L Fisk S | 1998 | Food Science and Technology Today1998，12，2： | 1 |
| 20 | Prenatal diagnosis by minimally invasive first - trimester transcervical sampling is unreliable 显示文摘 | Overton T D Lighten A D Fisk N M | 1996 | Am J Obstet Gynecol1996，175，： | 1 |
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